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Endothelial Function and Progenitor Cells in Acute Ischemic Stroke — EPCAS  

Ischemic Stroke Clinical Trial

Official title:
Endothelial Function and Progenitor Cells in Acute Ischemic Stroke

Clinical Trial Summary

The purpose of this study is to determine whether levels of circulating endothelial progenitor cells (cEPC) are increased in the acute phase of ischemic stroke.

Clinical Trial Description

Endothelial dysfunction is a key component of atherosclerosis which contributes to the development of cardio- and cerebrovascular diseases. However, endothelial dysfunction (ED) is not established as a risk factor for ischemic stroke.

As a novelty the proposed trial investigates the following variety of indirect markers of endothelial function in acute ischemic stroke:

circulating endothelial progenitor cells (EPC), endothelial microparticles (EMP), ENDOPAT (RH- PAT ratio) in two regards:

1. time after ischemic events (< 48h, Days 4-5, day 7 or at discharge)

2. etiological stroke subtypes

It is not known whether these parameters are changed after acute cerebral ischemia and could possibly serve as specific target for treatment. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01289795
Study type Observational
Source Charite University, Berlin, Germany
Contact Thomas Liman, MD
Phone 004930450560643
Email thomas.liman@charite.de
Status Recruiting
Phase N/A
Start date July 2010
Completion date June 2012
View Details
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