Leipzig Adipose Tissue Childhood Cohort

Status Recruiting

Clinical Trial Summary

In this study the investigators hypothesize that pathological alterations in adipose tissue biology already occur during the development and progression of obesity in children and adolescents. The investigators aim to identify and characterize mechanisms and molecular targets that affect the development of adipose tissue and ensuing obesity in childhood and adolescence.

Clinical Trial Description

The investigators aim to identify how adipose tissue dysfunction in childhood contributes to the development of obesity and related comorbidities and to characterize factors that play a role in the development of adipose dysfunction in children. The investigators will employ a translational approach which is based on the characterization of adipose tissue biology in samples of children to determine alterations leading to adipose tissue dysfunction. These include assessment of the composition (including BAT), remodeling, function, metabolism and inflammation of adipose tissue as well as the adipokine profile. For the assessment of clinical relevance, these experimental data will then be correlated with the clinical phenotype. Finally, we aim to identify factors responsible for early adipose tissue dysfunction and characterize them for their clinical and functional relevance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02208141
Study type	Observational
Source	University of Leipzig
Contact	Antje Körner, Prof. Dr.
Phone	0049/(0)341-9726854
Email	Antje.Koerner@medizin.uni-leipzig.de
Status	Recruiting
Phase
Start date	October 2010
Completion date	December 2030

View Details

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