| Eligibility |
Inclusion Criteria:
1. Aged 18-65 years
2. Able to read and understand English and willing to provide informed consent/comply
with the study protocol
3. Willingness to complete intravenous infusion and have blood drawn
4. Exhibit circulating blood level of C reactive protein = 3mg/L
5. Diagnosed with Major Depressive Disorder
6. Moderate depressive symptom severity, as indicated by score =15 on the Hamilton
Depression Rating Scale
7. Antidepressant treatment free for at least 4 weeks prior to study entry or be on a
fixed treatment regimen for at least 4 weeks; willingness to continue treatment status
(i.e., change/begin new treatment) until study termination
8. Willingness not to begin/change therapies until study termination (maximum of three
weeks following screening)
9. Be of non-childbearing potential per the following specific criteria:
a. Non-childbearing potential (e.g., physiologically incapable of becoming pregnant,
i.e., permanently sterilized (status post hysterectomy, bilateral tubal ligation), or
is post-menopausal with her last menses at least one year prior to screening); or b.
Childbearing potential and meets the following criteria: i. A negative serum pregnancy
test within thirty days of infusion (may be repeated closer to infusion date at the
discretion of the PI or study staff) and abstinent after the negative serum pregnancy
test and prior to infusion; or ii. Using any form of hormonal birth control, on
hormone replacement therapy started prior to 12 months of amenorrhea, using an
intrauterine device (IUD), having a monogamous relationship with a partner who has had
a vasectomy, or is sexually abstinent; iii. Continuously use one of the following
methods of birth control over the last six months: implants, injectable or patch
hormonal contraception, oral contraceptives, IUD, double-barrier contraception, sexual
abstinence.
Exclusion Criteria:
1. Medical conditions that could confound interpretation or increase participant risk, as
indicated via medical history or laboratory testing; exclusionary medical conditions
will include:
i. acute injury/infection within one week of study initiation or infection within one
month of study initiation that required antibiotic/antiviral treatment ii. chronic
infection (e.g., hepatitis B or C or HIV) or history of Covid 19 infection within the
past 6 months or with persisting symptoms.
iii. latent infection (e.g., tuberculosis, fungal infections), or history of recurrent
infections, iv. uncontrolled cardiovascular, endocrine, hematologic, hepatic, renal or
neurologic disease (as determined by medical history, physical exam and laboratory
testing) v. cancer history vi. autoimmune conditions; neurologic conditions
(controlled) that are known to substantially impact cognitive function (e.g., stroke).
Of note, stable medical conditions such as diabetes and cardiovascular disease, will
be allowed in the study as they can contribute to endogenous inflammation.
2. Active antipsychotic and anticonvulsant medication use (that interact with infliximab)
3. Prior use of a TNF antagonist or use of systemic corticosteroids or anti-proliferative
agents within one year of study entry
4. History of liver abnormalities
5. Major cognitive impairment as determined by study investigators
6. Active restrictive eating disorder or obsessive compulsive disorder deemed by study
investigators to be primary cause of depressive disorder
7. History of a psychotic disorder or Bipolar disorder type I/II
8. Current substance use disorder (i.e., present in last six months), of greater than
mild severity
9. Suicidal ideation based on a score =3 on the Columbia-Suicide Severity Rating Scale
10. Electroconvulsive therapy (ECT)/deep brain stimulation (DBS) within the last year, or
report of persistent negative cognitive effects of ECT/DBS
11. Presence of a transplanted solid organ
12. Medication use affecting immune or cognitive function:
i. Chronic use (>1 month) of a benzodiazepine more than the equivalent of 2 mg of
lorazepam ii. Use of anti-inflammatory agents during the study: non-steroidal
anti-inflammatory agents (NSAIDs) (excluding 81mg of aspirin), glucocorticoid
containing medicines or statins, or cyclooxygenase-2 (COX-2) inhibitors
13. Considered by the study investigators to be inappropriate for the study due to safety
concerns or to be unlikely to complete the protocol
14. History of allergic response to murine products
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