ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation

Inflammation Clinical Trial

— ZEUS  

Official title:

ZEUS - Effects of Ziltivekimab Versus Placebo on Cardiovascular Outcomes in Participants With Established Atherosclerotic Cardiovascular Disease, Chronic Kidney Disease and Systemic Inflammation

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05021835
• Other study ID #: EX6018-4758
• Secondary ID: U1111-1259-34222
• Status: Recruiting
• Phase: Phase 3
• Start date: August 30, 2021
• Est. completion date: January 29, 2026

Study information

• Verified date: June 2024
• Source: Novo Nordisk A/S
• Contact: Novo Nordisk
• Phone: (+1) 866-867-7178
• Email: clinicaltrials[@]novonordisk.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation.

Participants will either get ziltivekimab (active medicine) or placebo (a dummy medicine which has no effect on the body). This is known as the study medicine. Which treatment participants get is decided by chance. Participants chance of getting ziltivekimab or placebo is the same.

Ziltivekimab is not yet approved in any country or region in the world. It is a new medicine doctors cannot prescribe.

Participants will get the study medicine in a pre filled syringe. Participants will need to use the pre filled syringe to inject the study medicine into a skinfold once-monthly.

The study is expected to last for up to 4 years. Participants will have up to 20 clinic visits. Participants will have blood and urine samples taken at most of the clinic visits.

Participants will have their heart examined using sound waves (echocardiography) and electrodes (electrocardiogram).

Women cannot take part if pregnant, breast-feeding or planning to get pregnant during the study period.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 6200
• Est. completion date: January 29, 2026
• Est. primary completion date: September 24, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Chronic kidney disease defined by one of the below:

1. Estimated glomerular filtration rate (eGFR) greater than or equal to (>=) 15 and below 60 mL/min/1.73 m^2 (using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation)

2. Urinary albumin-to-creatinine ratio (UACR) >= 200 milligrams per gram (mg/g) and eGFR >= 60 mL/min/1.73 m2 (using the CKD-EPI creatinine equation)

• Serum high-sensitivity C-reactive protein (hs-CRP) greater than or equal to 2 milligram per liter (mg/L)

• Evidence of atherosclerotic cardiovascular disease (ASCVD) by one or more of the following:

a) Coronary heart disease defined as at least one of the following: i. Documented history of MI ii. Prior coronary revascularisation procedure iii. greater than or equal to 50% stenosis in major epicardial coronary artery documented by cardiac catheterisation or CT coronary angiography b) Cerebrovascular disease defined as at least one of the following: i. Prior stroke of atherosclerotic origin ii. Prior carotid artery revascularisation procedure iii. greater than or equal to 50% stenosis in carotid artery documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound.

c) Symptomatic peripheral artery disease (PAD) defined as at least one of the following: i. Intermittent claudication with an ankle-brachial index (ABI) below or equal to 0.90 at rest ii. Intermittent claudication with a greater than or equal to 50% stenosis in peripheral artery (excluding carotid) documented by X-ray angiography, MR angiography, CT angiography or Doppler ultrasound iii. Prior peripheral artery (excluding carotid) revascularisation procedure iv. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g. trauma or osteomyelitis).

Exclusion Criteria:

• Clinical evidence of, or suspicion of, active infection at the discretion of the investigator.

• Myocardial infarction, stroke, hospitalisation for unstable angina pectoris, or transient ischaemic attack within 60 days prior to randomisation (visit 2).

• Planned coronary, carotid or peripheral artery revascularisation known on the day of randomisation (visit 2).

• Major cardiac surgical, non-cardiac surgical, or major endoscopic procedure (thoracoscopic or laparoscopic) within the past 60 days prior to randomisation (visit 2) or any major surgical procedure planned at the time of randomisation (visit 2).

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Cardiovascular Risk
• Chronic Disease
• Chronic Kidney Disease
• Inflammation
• Kidney Diseases
• Renal Insufficiency, Chronic

Intervention

Drug:
• Ziltivekimab B
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
• Ziltivekimab C
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
• Placebo (Ziltivekimab B)
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.
• Placebo (Ziltivekimab C)
Administered subcutaneously (s.c., under skin) once-monthly added to standard of care.

Locations

Country	Name	City	State
Argentina	Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli	Buenos Aires
Argentina	Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli	Buenos Aires
Argentina	Centro Medico Lebensohn	Buenos Aires
Argentina	CEMEDIC	Caba	Buenos Aires
Argentina	Centro Médico Viamonte SRL	Caba
Argentina	Instituto Cardiovascular Buenos Aires	Caba	Buenos Aires
Argentina	Mautalen Salud e investigación	Caba	Buenos Aires
Argentina	Mautalen Salud e investigación	Caba	Buenos Aires
Argentina	Sanatorio Finochietto	Caba	Buenos Aires
Argentina	Centro de Educación Médica e Investigaciones Clínicas Saaved	Capital Federal
Argentina	Cardiología Palermo	Ciudad Autónoma de Buenos Aire
Argentina	Instituto Médico DAMIC	Córdoba
Argentina	Hospital Italiano de la Plata	La Plata	Buenos Aires
Argentina	Centro de Investigaciones Médicas Clínica de Fracturas y Or	Mar del Plata	Buenos Aires
Argentina	Instituto Médico CER	Quilmes - Buenos Aires
Argentina	Investigaciones Clinicas Tucuman	San Miguel De Tucumán, Tucumán.
Argentina	Instituto de Investigaciones Clinicas San Nicolás	San Nicolás
Australia	Nightingale Research	Adelaide	South Australia
Australia	Royal Adelaide Hospital Cardiovascular Clinical Trials	Adelaide	South Australia
Australia	Sunshine Coast University Hospital	Birtinya	Queensland
Australia	Monash Health Heart	Clayton	Victoria
Australia	St Vincent's Hospital_Fitzroy_0	Fitzroy	Victoria
Australia	The Canberra Hospital_Garran	Garran	Australian Capital Territory
Australia	Geelong Cardiology Research Unit	Geelong	Victoria
Australia	Gosford Renal Research	Gosford	New South Wales
Australia	Royal Hobart Hospital	Hobart	Tasmania
Australia	HeartCare WA (Joondalup)	Joondalup	Western Australia
Australia	St George Hospital	Kogarah	New South Wales
Australia	HeartCare SA	Leabrook	South Australia
Australia	Core Research Centre	Milton	Queensland
Australia	Melbourne Renal Research Group	Reservoir	Victoria
Australia	Sunshine Hospital	St Albans	Victoria
Australia	Royal North Shore Hospital	St Leonards	New South Wales
Australia	La Trobe Regional Hospital	Traralagon	Victoria
Australia	Westmead Applied Research Centre	Westmead	New South Wales
Australia	Illawarra Heart Health Centre	Wollongong	New South Wales
Australia	Illawarra Heart Health Centre	Wollongong	New South Wales
Belgium	Algemeen Stedelijk Ziekenhuis - Aalst - Interventional Cardiology	Aalst
Belgium	Imeldaziekenhuis - Bonheiden - Department of Endocrinology	Bonheiden
Belgium	Imeldaziekenhuis - Bonheiden - Department of Endocrinology	Bonheiden
Belgium	AZ Klina - Brasschaat - Cardiology	Brasschaat
Belgium	AZ Sint-Jan - Campus Brugge	Brugge
Belgium	AZ Sint-Jan - Campus Brugge_Brugge	Brugge
Belgium	Ziekenhuis Oost Limburg - Cardiology	Genk
Belgium	Ziekenhuis Oost-Limburg AV - Cardiology	Genk
Belgium	AZ Groeninge - Kortrijk - Cardiology	Kortrijk
Belgium	AZ Groeninge - Kortrijk - Cardiology	Kortrijk
Belgium	CHR de la Citadelle	Liège
Belgium	AZ Sint-Maarten Mechelen - Cardiology	Mechelen
Belgium	AZ OOSTENDE (Campus DAMIAAN)	Oostende
Brazil	Hospital Felicio Rocho	Belo Horizonte	Minas Gerais
Brazil	Hospital Felicio Rocho	Belo Horizonte	Minas Gerais
Brazil	AngioCor Blumenau	Blumenau	Santa Catarina
Brazil	AngioCor Blumenau	Blumenau	Santa Catarina
Brazil	Hospital do Coração do Brasil	Brasilia	Distrito Federal
Brazil	i9 Pesquisas Clínicas	Campinas	Sao Paulo
Brazil	Instituto de Pesquisa Clínica de Campinas	Campinas	Sao Paulo
Brazil	PUCCAMP - Hospital e Maternidade Celso Pierro	Campinas	Sao Paulo
Brazil	Integral Pesquisa e Ensino	Cidade Nova Votuporanga	São Paulo
Brazil	Instituto Pró-Renal Brasil	Curitiba	Parana
Brazil	Núcleo de Pesquisa Clínica S/S	Curitiba	Parana
Brazil	Irmandade da Santa Casa de Misericordia de Porto Alegre	Porto Alegre/ RS
Brazil	HBA S/A Assistência Médica e Hospitalar	Salvador
Brazil	Praxis Pesquisa Médica	Santo André	São Paulo
Brazil	CEMEC - Centro Multidisciplinar de Estudos Clínicos	São Bernardo Do Campo/SP
Brazil	CEMEC - Centro Multidisciplinar de Estudos Clínicos	São Bernardo Do Campo/SP
Brazil	CIP Centro Integrado de Pesquisas do Hospital de Base	São José do Rio Preto	Sao Paulo
Brazil	CPQuali Pesquisa Clínica Ltda	São Paulo	Sao Paulo
Brazil	CPQuali Pesquisa Clínica Ltda	São Paulo	Sao Paulo
Brazil	Impar Serviços Hospitalares S/A	São Paulo	SP
Brazil	Instituto do Coração - HCFMUSP	São Paulo	Sao Paulo
Brazil	Centro de Diabetes e Obesidade - HRim e Hipertensao	São Paulo - SP
Brazil	Eurolatino Medical Research Center	Uberlândia	Minas Gerais
Brazil	Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo	Vitória	Espirito Santo
Bulgaria	Medical Centre Diamedical-2013	Dimitrovgrad
Bulgaria	'Medical center Medi city 21' OOD	Kyustendil
Bulgaria	"Medical Center Hera" EOOD - Montana	Montana
Bulgaria	SHACT Sveti Georgi - Pernik	Pernik
Bulgaria	"Medical center Medconsult Pleven" OOD	Pleven
Bulgaria	UMHAT Heart and Brain	Pleven
Bulgaria	"UMHAT "Sveti Georgi" EAD	Plovdiv
Bulgaria	'MHAT Hadzhi Dimitar' OOD	Sliven
Bulgaria	"Acibadem City Clinic UMHAT" EOOD, Sofia, Cardiology clinic	Sofia
Bulgaria	"Diagnostic - Consulting Center Aleksandrovska" EOOD	Sofia
Bulgaria	"Medical Center Hera" EOOD - Sofia	Sofia
Bulgaria	"MHAT "NCH" EAD, Clinic of Cardiology, Depart. of Cardiology	Sofia
Bulgaria	"UMHAT "Sveta Anna" Sofia"	Sofia
Bulgaria	"UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology	Sofia
Bulgaria	Medico-dental center ISUL - Tsaritsa Yoanna EOOD	Sofia
Bulgaria	UMHAT "Sveti Ivan Rilski"	Sofia
Bulgaria	UMHAT "Sveti Ivan Rilski"	Sofia
Bulgaria	UMHAT "Sveti Ivan Rilski"	Sofia
Bulgaria	"Prevencia-2000-MCOC"	Stara Zagora
Bulgaria	Medical Center "Nov Rehabilitatsionen center" EOOD	Stara Zagora
Bulgaria	UMHAT "Sveta Marina" EAD	Varna
Bulgaria	Medical center Berbatov	Yambol
Canada	LMC Diabetes & Endocrinology (Barrie)	Barrie	Ontario
Canada	LMC ClinRsrh Inc.Brampton	Brampton	Ontario
Canada	Viacar Recherche Clinique Inc.	Brossard	Quebec
Canada	C-endo Diab Endo Clin Calgery	Calgary	Alberta
Canada	LMC Clin Res Inc. Calgary	Calgary	Alberta
Canada	Cambridge Cardiac Care Centre	Cambridge	Ontario
Canada	LMC Clin Res Inc. Thornhill	Concord	Ontario
Canada	Centricity Research Etobicoke	Etobicoke	Ontario
Canada	Nova Scotia Hlth Halifax	Halifax	Nova Scotia
Canada	Hamilton Med Res Group	Hamilton	Ontario
Canada	Ctr de rech Clin de Laval	Laval	Quebec
Canada	One Heart Care	Mississauga	Ontario
Canada	LMC Research Inc. Ottawa	Nepean	Ontario
Canada	Partnrs Adv Cardio Eval (PACE)	Newmarket	Ontario
Canada	North York Diagn & Cardiac Ctr	North York	Ontario
Canada	LMC Clinical Research Inc. Oakville	Oakville	Ontario
Canada	Oakville Cardiovascular Research LP	Oakville	Ontario
Canada	Kawartha Cardiology Clinical Trials	Peterborough	Ontario
Canada	CHU de Quebec-Universite Laval	Quebec
Canada	Institut universitaire de cardiologie	Quebec
Canada	Recherche Clinique Sigma inc	Quebec
Canada	Heart Health Institute Research, Inc.	Scarborough	Ontario
Canada	Centre de recherché du CHUS	Sherbrooke	Quebec
Canada	Synergy Wellness Clinic	Sherwood Park	Alberta
Canada	Centre de santé et de services	Terrebonne	Quebec
Canada	Diabetes Heart Research Centre	Toronto	Ontario
Canada	LMC Endo Centres Ltd.(Bayview)	Toronto	Ontario
Canada	BC Diabetes Canada	Vancouver	British Columbia
Canada	BC Diabetes Canada	Vancouver	British Columbia
Canada	Clinical Research Solutions Inc.	Waterloo	Ontario
China	Beijing Anzhen Hospital, Capital Medical University	Beijing	Beijing
China	Beijing Hospital_Beijing	Beijing	Beijing
China	Chinese Academy of Medical Sciences Fuwai Hospital	Beijing
China	Chinses PLA General Hospital	Beijing	Beijing
China	Peking University First Hospital	Beijing	Beijing
China	Peking University Third Hospital_Beijing	Beijing	Beijing
China	Xuanwu Hospital Capital Medical University-Cardiology	Beijing	Beijing
China	China-Japan Union Hospital of Jilin University	Changchun	Jilin
China	The Second Hospital of Jilin University_Changchun	Changchun	Jilin
China	The First People's Hospital of Changde City -Internal Medicine-Cardiovascular	Changde
China	Changzhou No.2 People's Hospital	Changzhou	Jiangsu
China	The First People's Hospital of Changzhou	Changzhou
China	Sichuan Provincial People's Hospital, Nephrology	Chengdu
China	The Second Affiliated Hospital of Chongqing Medical Univeris	Chongqing	Chongqing
China	Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) Cardiology Department	Dalian
China	Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) Nephrology Department	Dalian
China	The First Affiliated Hospital of Dalian Medical University	Dalian	Liaoning
China	The First Affiliated Hospital of Dalian Medical University	Dalian	Liaoning
China	Fu Yang People's Hospital	Fu Yang
China	Zhujiang Hospital of Southern Medical University	Guangzhou
China	The First Affiliated Hospital, Zhejiang University School of Medicine-Cardiology	Hangzhou
China	Zhejiang Provincial People's Hospital	Hangzhou	Zhejiang
China	Zhejiang Provincial People's Hospital-Cardiology Department	Hangzhou	Zhejiang
China	Xingtai People's Hospital	Hebei/Xingtai
China	The Second Hospital of Anhui Medical University	Hefei	Anhui
China	The Second People Hospital of Huai'an - Nephrology	Huai'an
China	Huizhou Central People's Hospital_Internal Medicine-Cardiovascular Dept	Huizhou
China	Jinan Central Hospital Affiliated to Shandong University (Cardiovascular Dept)	Jinan
China	Jinan Central Hospital Affiliated to Shandong University (Cardiovascular Dept)	Jinan
China	The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)	Jinan	Shandong
China	The Second Hospital of Shandong University	Jinan
China	The Second Hospital of Shandong University	Jinan
China	Huashan Hospital Fudan University	Jingan/Shanghai
China	The First Affiliated Hospital of Jinzhou Medical University	Jinzhou	Liaoning
China	The Second Affiliated Hospital of Kunming Medical University	Kun Ming
China	Lanzhou University Second Hospital_Internal Medicine-Cardiovascular Dept	Lanzhou	Gansu
China	Linfen Central Hospital	Linfen	Shanxi
China	The First Affiliated Hospital of Henan University of Science and Technology	Luoyang
China	Jiangxi Provincial People's Hospital_Nanchang	Nanchang	Jiangxi
China	The First Affiliated Hospital of Nanchang University	Nanchang	Jiangxi
China	The First Affiliated Hospital of Nanchang University_Nanchang_0	Nanchang	Jiangxi
China	The Second Affiliated Hospital of Nanjing Medical University	Nanjing	Jiangsu
China	Zhongda Hospital, Southeast University	Nanjing	Jiangsu
China	The People's Hospital of Guangxi Zhuang Autonomous Region-Cardiology Department	Nanning
China	The People's Hospital of Guangxi Zhuang Autonomous Region-Nephrology Department	Nanning
China	Central Hospital of Minhang District	Shanghai	Shanghai
China	Shanghai General Hospital	Shanghai	Shanghai
China	Shanghai No. 6 People's Hospital	Shanghai	Shanghai
China	Xinhua Hospital Affiliated To Shanghai Jiao Tong University	Shanghai	Shanghai
China	The Second Affiliated Hospital of Shantou University Medical College	Shantou
China	Shengjing Hospital of China Medical University	Shenyang
China	Shenzhen People's Hospital	Shenzhen	Guangdong
China	The First Affiliated Hospital of Soochow University_Suzhou	Suzhou	Jiangsu
China	Tianjin 4th Center Hospital	Tianjin	Tianjin
China	Tianjin People's Hospital	Tianjin	Tianjin
China	Renmin Hospital of Wuhan University	Wuhan	Hubei
China	Tongji Hospital, Tongji Medical College of HUST_Wuhan	Wuhan	Hubei
China	Tongji Medical college of HUST Tongji Hospital-Cardiology	Wuhan	Hubei
China	Wuhan Union Hospital_Wuhan	Wuhan	Hubei
China	The First Affiliated Hospital of Xi'an Jiaotong University	Xi'an
China	Zhongshan Hospital Xiamen University	Xiamen	Fujian
China	The Third Affiliated Hospital Of Xinxiang Medical University	Xinxiang
China	The Affiliated Hospital Of Xuzhou Medical University	Xuzhou	Jiangsu
China	The First Affiliated Hospital of Zhengzhou University	Zhengzhou	Henan
China	The Affiliated Hospital of Jiangsu University	Zhenjiang	Jiangsu
China	The Affiliated Hospital of Jiangsu University_Zhenjiang_0	Zhenjiang	Jiangsu
Croatia	Specijalna bolnica Krapinske Toplice - Kardiologija	Krapinske Toplice	Krapinsko Zagorska County
Croatia	KBC Rijeka, Zavod za kardiomiopatije	Rijeka
Croatia	KBC Rijeka, Zavod za nefrologiju	Rijeka
Croatia	KBC Split / Krizine/ Kardiologija	Split
Croatia	Clinical Hospital Dubrava	Zagreb	Grad Zagreb
Croatia	KBC Zagreb, Klinika za bolesti srca i krvnih zila	Zagreb
Croatia	KBC Zagreb, Zavod za nefrologiju	Zagreb
Croatia	Poliklinika Solmed	Zagreb	Grad Zagreb
Czechia	Edumed Broumov	Broumov
Czechia	KARDIOLOGIE - LIBEREC s.r.o.	Liberec
Czechia	EDUMED s.r.o. Nachod	Nachod
Czechia	Medicon a.s.	Praha
Czechia	IKEM Klinika nefrologie	Praha 4
Czechia	Nemocnice Slany Kardiologie	Slany
Denmark	Aalborg Universitetshospital Kardiologisk Afdeling	Aalborg
Denmark	Aarhus Universitetshospital, Skejby Hjertesygdomme	Aarhus N
Denmark	Regionshospitalet Gødstrup, Hjertesygdomme	Herning
Denmark	Holbæk Sygehus	Holbæk	Region Sjælland
Denmark	Hvidovre Hospital Hjertemedicinsk	Hvidovre
Denmark	Kolding Sygehus Karkirurgi	Kolding
Denmark	Sjællands Universitetshospital_Roskilde	Roskilde
Denmark	Kardiologisk Odense & Svendborg	Svendborg
Denmark	Viborg Sygehus	Viborg
Germany	Universitaetsklinikum Aachen AöR	Aachen
Germany	Universitaetsklinikum Aachen AöR	Aachen
Germany	Kardiologische Praxis	Bad Homburg
Germany	Nephrologie, Charite Universitatsmedzin Berlin, Campus	Berlin
Germany	Praxis Dr.med. Frank Menzel	Dessau
Germany	Praxis Dr.med. Frank Menzel	Dessau
Germany	Hausaerztlich-Kardiologisches MVZ Am Felsenkeller GmbH	Dresden
Germany	Herzzentrum Dresden GmbH Universitaetsklinik	Dresden
Germany	Herzzentrum Dresden GmbH Universitätsklinik	Dresden
Germany	Kreutzmann	Dresden
Germany	Zentrum für klinische Prüfungen Dresden	Dresden
Germany	DaVita Clinical Research Deutschland GmbH	Düsseldorf
Germany	Zentrum fuer klinische Studien Suedbrandenburg GmbH	Elsterwerda
Germany	InnoDiab Forschung GmbH	Essen
Germany	Zentrum für klinische Forschung, Dr. med. Lüdemann	Falkensee
Germany	MVZ CCB Frankfurt Und Main-Taunus GbR	Frankfurt
Germany	MVZ CCB Frankfurt Und Main-Taunus GbR	Frankfurt
Germany	Nephrologie Universitätsklinikum Frankfurt	Frankfurt
Germany	Nephrologie Universitätsklinikum Frankfurt	Frankfurt
Germany	Studienzentrum ClinPhenomics	Frankfurt
Germany	Medical Center - University Of Freiburg	Freiburg	Baden-Württemberg
Germany	Nierenzentrum Freiburg	Freiburg
Germany	Universitätsklinikum Halle (Saale)	Halle (Saale)
Germany	Diabetesinstitut Heidelberg - St. Josefskrankenhaus	Heidelberg
Germany	UKS - Innere Medizin III	Homburg
Germany	UKS - Innere Medizin IV	Homburg Saar
Germany	University Hospital Jena KöR	Jena
Germany	University Hospital Jena KöR	Jena
Germany	SRH Klinikum Karlsbad - Langensteinbach GmbH	Karlsbad	Baden-Württemberg
Germany	Universitätsklinikum Schleswig-Holstein	Lübeck
Germany	Marienhaus Klinikum Mainz GmbH	Mainz
Germany	Universitätsmedizin Mainz, Kardiologie I, Studienzentrum	Mainz
Germany	zero PRAXEN Mannheim-Schwetzingerstadt	Mannheim
Germany	RED-Institut für medizinische Forschung und Fortbildung GmbH	Oldenburg in Holstein	Holstein
Germany	Praxis Reichelsheim	Reichelsheim
Germany	Praxis Reichelsheim	Reichelsheim
Germany	Praxis Reichelsheim	Reichelsheim
Germany	MEDINOS Kliniken Sonneberg GmbH	Sonneberg	Thüringen
Germany	Forschungszentrum Ruhr KliFoCenter GmbH, Dr. med. Kahrmann	Witten
Germany	Kahrmann	Witten
Greece	Alexandroupoli University General Hospital	Alexandroupoli
Greece	"Hygeia" General Hospital of Athens	Athens
Greece	"Hygeia" General Hospital of Athens	Athens
Greece	"Laiko" General Hospital of Athens	Athens
Greece	"Sotiria" Thoracic Diseases Hospital of Athens	Athens
Greece	Alexandra General Hospital, Therapeutic Clinic	Athens
Greece	Hippokration Hospital	Athens
Greece	Iatriko Athinon 'Palaiou Falirou'	Athens
Greece	Iatriko Athinon 'Palaiou Falirou'	Athens
Greece	Iatriko Athinon (Athens Medical Canter)	Athens
Greece	Konstantopouleio G.H. of Athens, "Agia Olga"	Athens
Greece	Konstantopouleio G.H. of Athens, "Agia Olga"	Athens
Greece	General Hospital of Chios "Skilitsio"	Chios
Greece	University Hospital of Athens ATTIKON	Haidari-Athens
Greece	University Hospital of Athens ATTIKON	Haidari-Athens	Attica
Greece	Periphery University Hospital of Heraklion	Heraklion
Greece	University General Hospital of Ioannina,Internal Medicine	Ioannina
Greece	KAT General Hospital of Attica	Kifissia
Greece	KAT General Hospital of Attica	Kifissia
Greece	General Hospital of Lamia	Lamia
Greece	Univ Gen Hospital Larisa, Cardiology Medicine Clinic	Larissa
Greece	Iatriko Athinon (Athens Medical Canter)	Pylea, Thessaloniki
Greece	General University Hospital of Patras,Nephrology clinic	Rio, Patra
Greece	"AHEPA" University General Hospital of Thessaloniki	Thessaloniki
Greece	"AHEPA" University Hospital of Thessaloniki	Thessaloniki
Greece	"Thermi" Private Hosital	Thessaloniki
Greece	Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt	Thessaloniki
Greece	General Hospital of Thessaloniki "Ippokrateio"	Thessaloniki
Greece	General Hospital of Thessaloniki 'Agios Pavlos'	Thessaloniki
Greece	General Hospital of Thessaloniki 'Ippokrateio' Dialysis Unit	Thessaloniki
Hungary	EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság	Baja
Hungary	Tagore Medical Center	Balatonfüred
Hungary	Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés	Békéscsaba	Békés Megye
Hungary	Gottsegen György Országos Kardiológiai Intézet	Budapest
Hungary	Jahn Ferenc Dél-pesti Kórház és Rendelointézet	Budapest
Hungary	DE KK Kardiológiai és Szívsebészeti klinika	Debrecen
Hungary	Selye János Kórház	Komárom	Komárom-Esztergom
Hungary	Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ	Szeged
Hungary	Léda Platán Magánklinika	Zalaegerszeg	Zala Megye
India	Apollo CHSF Heart Institute	Ahmedabad	Gujarat
India	Kamalnayan Bajaj Hospital	Aurangabad	Maharashtra
India	Kamalnayan Bajaj Hospital	Aurangabad	Maharashtra
India	Lifecare Hospital and Research Centre	Bangalore	Karnataka
India	Lifecare Hospital and Research Centre	Bangalore	Karnataka
India	Manipal Hospital, Old Airport Road, Bengaluru	Bangalore	Karnataka
India	KLES & Prabhakar Kore Hospital and Research Centre	Belgaum	Karnatka
India	Sri Jayadeva Institute of Cardiovascular Sciences & Research	Bengaluru	Karnataka
India	Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh	Chandigarh
India	Apollo Hospitals Education & Research Foundation	Chennai	Tamil Nadu
India	Lalitha Super Specialities Hospital	Guntur	Andhra Pradesh
India	Vedanta Hospitals	Guntur	Andhra Pradesh
India	Apollo Hospital Jubilee Hills, Hyderabad	Hyderabad	Telengana
India	Guru Nanak CARE Hospitals	Hyderabad	Telangana
India	NIZAM'S Institute of Medical Sciences	Hyderabad	Andhra Pradesh
India	NIZAM'S Institute of Medical Sciences	Hyderabad	Andhra Pradesh
India	Osmania General Hospital	Hyderabad	Telengana
India	Osmania General Hospital_Hyderabad	Hyderabad	Telengana
India	Osmania General Hospital	Hyderbad	Telengana
India	Eternal Heart Care Centre	Jaipur
India	Lisie Hospital	Kochi	Kerala
India	Calicut Medical College	Kozhikode	Kerala
India	Gandhi Memorial Hospital- King George's Medical University	Lucknow	Uttar Pradesh
India	Medanta Lucknow Hospital	Lucknow	Uttar Pradesh
India	Dayanand Medical College & Hospital	Ludhiana	Punjab
India	Dayanand Medical College & Hospital	Ludhiana	Punjab
India	Omega Hospital (P) Limited	Mangalore	Karnataka
India	Kasturba Medical College and Hospital	Manipal	Karnataka
India	Kasturba Medical College and Hospital, Manipal	Manipal	Karnataka
India	Seth GS medical college and KEM Hospital	Mumbai	Maharashtra
India	Arneja Heart & Multispeciality Hospital	Nagpur	Maharashtra
India	Government Medical College and Super Speciality Hospital, Nagpur	Nagpur	Maharashtra
India	Shri Krishna Hrudayalaya & Critical Care Centre	Nagpur	Maharashtra
India	Chopda Medicare and Research Centre Pvt. Ltd.	Nashik	Maharashtra
India	Vijan Hospital & Research Centre	Nashik	Maharashtra
India	VMMC & Safdarjung Hospital	New Dehli	New Delhi
India	Batra Hospital and Medical Research Center	New Delhi	Delhi
India	Fortis Escort Health Institute	New Delhi
India	Fortis Escorts Heart Institute, New Delhi	New Delhi	Delhi
India	G B Pant Institute of Postgraduate Medical Education and Res	New Delhi
India	G B Pant Institute of Postgraduate Medical Education and Research	New Delhi	Delhi
India	Lok Nayak Hospital	New Delhi
India	Max Super Speciality Hospital, Saket	New Delhi
India	Max Super Speciality Hospital_New Delhi	New Delhi
India	Sir Ganga Ram Hospital	New Delhi
India	Lakshmi Hospital	Palakkad
India	B J Goverment Medical College and Sassoon General Hospital	Pune	Maharashtra
India	B J Goverment Medical College and Sassoon General Hospital	Pune	Maharashtra
India	Grant Medical Foundation	Pune	Maharashtra
India	BAPS Pramukh Swami Hospital	Surat	Gujarat
India	Shri B. D. Mehta Mahavir Heart Institute	Surat	Gujarat
India	Unicare heart institute and research centre	Surat	Gujarat
India	Government Medical College Trivandrum	Trivandrum	Kerala
India	Sunrise Hospital	Vijayawada	Andhra Pradesh
Israel	Diabetes Clinic Wolfson MC	Holon
Israel	Hadassah Ein Kerem MC - Cardio	Jerusalem
Israel	Cardiology department, Western Galilee Medical Center	Nahariya
Israel	Belinson hospital, Rabin medical center	Petach Tikva
Israel	Kaplan Medical Center_Rehovot	Rehovot
Israel	Cardio Vascular Research Center Sourasky MC	Tel Aviv
Israel	Sheba Medica Center - Clinical Research Unit	Tel Hashomer
Italy	West Vicenza General Hospital	Arzignano (VI)
Italy	ASST Papa Giovanni XXIII	Bergamo	Bg
Italy	Policlinico S. Orsola - Malpighi	Bologna
Italy	AO Cannizzaro	Catania
Italy	Azienda Ospedaliero-Universitaria Renato Dulbecco	Catanzaro	Cz
Italy	Università degli studi G. D'Annunzio Chieti Pescara - CAST	Chieti Scalo
Italy	A.O.U. Ferrara, Sant'Anna	Cona (Ferrara)	Fe
Italy	AOU Careggi Firenze	Firenze
Italy	IRCCS Azienda Ospedaliero Universitaria San Martino - IST	Genova
Italy	Ospedale San Raffaele-Cardiovascular Rehabilitation and Prev	Milan
Italy	Centro Cardiologico Monzino. Istituto di Ricovero e Cura	Milano
Italy	ASST degli Spedali Civili di Brescia-Presidio Ospedaliero di Montichiari	Montichiari
Italy	Azienda Ospedaliera Universitaria Federico II di Napoli	Napoli
Italy	AOUP Giaccone Palermo	Palermo
Italy	ARNAS Ospedali Civico Di Cristina Benfratelli	Palermo
Italy	Fondazione IRCCS Policlinico San Matteo	Pavia
Italy	AOU Pisana Cisanello	Pisa
Italy	Policlinico A. Gemelli IRCCS	Roma
Italy	Policlinico Tor Vergata	Roma
Italy	Policlinico Umberto I Seconda Clinica Medica	Roma	RM
Italy	AOU S. Andrea	Rome
Italy	Azienda Sanitaria Univ Giuliano Isontina	Trieste
Italy	AOUI Verona	Verona
Japan	NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine	Bunkyo-ku, Tokyo
Japan	NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine	Bunkyo-ku, Tokyo
Japan	The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine	Bunkyo-ku, Tokyo
Japan	Akaicho Clinic	Chiba-shi, Chiba
Japan	Fukuokaken Saiseikai Futsukaichi Hospital_Cardiovascular Medicine	Chikushino-shi, Fukuoka
Japan	University of Yamanashi Hospital_Cardiology	Chuo-city, Yamanashi
Japan	University of Yamanashi Hospital_Cardiology	Chuo-city, Yamanashi
Japan	National Hospital Organization Kyushu Medical Center	Fukuoka-shi
Japan	Fukuoka University Hospital_Cardiology	Fukuoka-shi, Fukuoka
Japan	Saiseikai Fukuoka General Hospital	Fukuoka-shi, Fukuoka
Japan	National Hospital Organization Hamada Medical Center	Hamada-shi, Shimane
Japan	JA Shizuoka Kohseiren Enshu Hospital_ cardiology	Hamamatsu-shi, Shizuoka
Japan	JA Shizuoka Kohseiren Enshu Hospital_ cardiology	Hamamatsu-shi, Shizuoka
Japan	Naka Kinen Clinic	Ibaraki
Japan	National Hospital Organization Mito Medical Center_Cardiovascular medicine	Ibaraki
Japan	Nishiyamado Keiwa Hospital	Ibaraki,
Japan	Kishiwada Tokushukai Hospital	Kishiwada, Osaka
Japan	North Alps Medical Center Azumi Hospital	Kita-azumi-gun, Nagano
Japan	Steel Memorial Yawata Hospital	Kitakyushu-shi, Fukuoka
Japan	Kokura Memorial Hospital, Cardiology	Kitakyushu-shi,Fukuoka
Japan	National Hospital Organization Fukuokahigashi Medical Center	Koga-shi, Fukuoka
Japan	Seino Internal Medicine Clinic	Koriyama-shi	Fukushima, Japan
Japan	Jinnouchi Hospital	Kumamoto-shi	Kumamoto, Japan
Japan	Kumamoto University Hospital, Cardiovascular Medicine	Kumamoto-shi, Kumamoto
Japan	Kumamoto University Hospital, Cardiovascular Medicine	Kumamoto-shi, Kumamoto
Japan	NHO Kure Medical Center and Chugoku Cancer Center	Kure-shi, Hiroshima
Japan	Kyoto Okamoto Memorial Hospital	Kusegun, Kyoto
Japan	NHO Kyoto medical center	Kyoto-shi, Kyoto
Japan	Rakuwakai Otowa Hospital	Kyoto-shi, Kyoto
Japan	Rakuwakai Otowa Hospital	Kyoto-shi, Kyoto
Japan	Ijinkai Takeda General Hospital, Cardiovascular Medicine	Kyoto-shi,Kyoto
Japan	Maebashi Red Cross Hospital	Maebashi-shi, Gunma
Japan	Matsubara Tokushukai Hospital	Matsubara-shi, Osaka
Japan	Chiba-Nishi General Hospital, Cardiology	Matsudo-shi
Japan	Chiba-Nishi General Hospital, Cardiology	Matsudo-shi
Japan	Shinshu University Hospital_Matsumoto-shi, Nagano	Matsumoto-shi, Nagano
Japan	Mishuku Hospital_Meguro-ku, Tokyo	Meguro-ku, Tokyo
Japan	Tokyo Saiseikai Central Hospital	Minato-ku, Tokyo
Japan	Hayama Heart Center	Miura-gun, Kanagawa
Japan	Miyakonojo Medical Association Hospital	Miyakonojo-shi, Miyazaki
Japan	Miyakonojo Medical Association Hospital	Miyakonojo-shi, Miyazaki
Japan	Miyazaki Medical Association Hospital	Miyazaki-shi	Miyazaki
Japan	Iwate Prefectural Central Hospital	Morioka-shi, Iwate
Japan	Nagoya University Hospital_Nagoya-shi, Aichi	Nagoya-shi, Aichi
Japan	Social Medical Corporation Kojunkai Daido Clinic	Nagoya-shi, Aichi
Japan	Naha City Hospital	Naha-shi, Okinawa
Japan	Nara Prefecture General Medical Center	Nara-shi, Nara
Japan	Nara Prefecture General Medical Center	Nara-shi, Nara
Japan	Hyogo Prefectural Nishinomiya Hospital	Nishinomiya-shi, Hyogo
Japan	Oita Medical Center_Cardiology	Oita-shi, Oita
Japan	Oita Medical Center_Cardiology	Oita-shi, Oita
Japan	Oita Medical Center_Cardiology	Oita-shi, Oita
Japan	Kawasaki Medical School Hospital	Okayama
Japan	Omihachiman Community Medical Center_Omihachiman-shi, Siga	Omihachiman-shi, Siga
Japan	Saiseikai Suita Hospital_Cardiovascular Medicine	Osaka
Japan	Takatsuki Red Cross Hospital	Osaka
Japan	Yao Tokushukai General Hospital	Osaka
Japan	Sakurabashi Watanabe Advanced Healthcare Hospital	Osaka-city, Osaka
Japan	Kitada Clinic	Osaka-shi, Osaka
Japan	Osaka City General Hospital_Osaka-shi, Osaka	Osaka-shi, Osaka
Japan	Yodogawa Christian Hospital	Osaka-shi, Osaka
Japan	Social Corporation Keigakukai Minami Osaka Hospital	Osaka-shi,Osaka
Japan	Ota Memorial Hospital	Ota-shi, Gunma
Japan	Kitasato University Hospital_Sagamihara-shi, Kanagawa	Sagamihara-shi, Kanagawa
Japan	Kitasato University Hospital_Sagamihara-shi, Kanagawa	Sagamihara-shi, Kanagawa
Japan	National Hospital Organization Sagamihara National Hospital	Sagamihara-shi, Kanagawa
Japan	National Hospital Organization Sagamihara National Hospital	Sagamihara-shi, Kanagawa
Japan	Sanai Hospital	Saitama-shi, Saitama
Japan	Hanaoka Seishu Memorial Hospital	Sapporo-shi, Hokkaido
Japan	Sendai Cardiovascular Center_Cardiology	Sendai-shi, Miyagi
Japan	Sendai Cardiovascular Center_Cardiology	Sendai-shi, Miyagi
Japan	Shinden Higashi Clinic	Sendai-shi, Miyagi
Japan	Shinden Higashi Clinic	Sendai-shi, Miyagi
Japan	Tohoku University Hospital, Cardiovascular	Sendai-shi, Miyagi
Japan	Osaka Saiseikai Senri Hospital	Suita-shi, Osaka
Japan	Saiseikai Suita Hospital_Suita-shi, Osaka	Suita-shi, Osaka
Japan	National Hospital Organization Disaster Medical Center_Nephrology	Tachikawa-shi, Tokyo
Japan	Kagawa Prefectural Central Hospital, Cardiovascular Medicine	Takamatsu-shi, Kagawa
Japan	Takamatsu Red Cross Hospital_Cardiovascular Medicine	Takamatsu-shi, Kagawa
Japan	Minamino Cardiovascular Hospital	Tokyo
Japan	Minamino Cardiovascular Hospital	Tokyo
Japan	Saiseikai tondabayashi Hospital	Tondabayashi-shi, Osaka
Japan	Tsukuba Medical Center Hospital_Department of Cardiology	Tsukuba-shi, Ibaraki
Japan	Uwajima City Hospital_ Cardiology	Uwajima-shi	Ehime
Japan	Japanese Red Cross Wakayama Medical Center_Diabetology and Endocrinology	Wakayama
Japan	National Hospital Organization Saitama Hospital	Wako-shi, Saitama
Japan	National Hospital Organization Saitama Hospital	Wako-shi, Saitama
Japan	Saiseikai Yokohamashi Nanbu Hospital_Cardiology	Yokohama-shi, Kanagawa
Japan	Yokohama City University Hospital	Yokohama-shi, Kanagawa
Japan	Yokohama City University Hospital	Yokohama-shi, Kanagawa
Japan	Sanyudo Hospital	Yonezawa-shi, Yamagata
Japan	Sanyudo Hospital	Yonezawa-shi, Yamagata
Korea, Republic of	Dong-A University Medical Center	Busan
Korea, Republic of	Pusan National University Hospital	Busan
Korea, Republic of	Daegu Catholic Univ. Medical Center	Daegu
Korea, Republic of	Keimyung University Dongsan Medical Center	Daegu
Korea, Republic of	Chungnam National University Hospital	Daejeon
Korea, Republic of	Wonju Severance Christian Hospital	Gangwon-do
Korea, Republic of	National Health Insurance Corporation Ilsan Hospital	Goyang
Korea, Republic of	Chonnam National University Hospital	Gwangju
Korea, Republic of	Hallym University Sacred Heart Hospital	Gyeonggi-Do
Korea, Republic of	Hanyang University GURI Hospital	Gyeonggi-do
Korea, Republic of	Seoul National University Bundang Hospital	Gyeonggi-do
Korea, Republic of	Gachon University Gil Medical Center	Incheon
Korea, Republic of	Gangdong Kyung Hee University Hospital	Seoul
Korea, Republic of	KangNam Sacred Heart Hospital	Seoul
Korea, Republic of	Konkuk University Medical Center	Seoul
Korea, Republic of	Korea University Anam Hospital	Seoul
Korea, Republic of	Korea University Guro Hospital	Seoul
Korea, Republic of	Kyunghee University Medical Center	Seoul
Korea, Republic of	Nowon Eulji Medical Center, Eulji University	Seoul
Korea, Republic of	Seoul National University Hospital	Seoul
Korea, Republic of	Seoul Saint Mary's Hospital	Seoul
Korea, Republic of	Severance Hospital, Yonsei University Health System	Seoul
Latvia	Ari Med	Daugavpils
Latvia	Daugavpils Regional Hospital	Daugavpils
Latvia	Daugavpils Regional Hospital	Daugavpils
Latvia	Zemgales diabetes centre	Jelgava
Latvia	Adoria	Riga
Latvia	P. Stradins Clinical University Hospital	Riga
Latvia	P. Stradins Clinical University Hospital	Riga
Latvia	Riga East Clinical University Hospital - Clinic "Gailezers"	Riga
Lithuania	Klinikiniai sprendimai, Alytus	Alytus
Lithuania	Hospital of Lithuanian university of health sciences Kauno	Kaunas
Lithuania	JSC "Saules seimos medicinos centras"	Kaunas
Lithuania	Kaunas City polyclinic Dainava Branch	Kaunas
Lithuania	Kaunas City Polyclinic, Silainiu department	Kaunas
Lithuania	Kaunas City Polyclinic, Silainiu department	Kaunas
Lithuania	Klinikiniai sprendimai, Kaunas	Kaunas
Lithuania	Lithuanian university of health sciences Clinical hospital	Kaunas
Lithuania	Klaipeda university hospital	Klaipeda
Lithuania	Republican Panevezys Hospital	Panevezys
Lithuania	Pirmoji Viltis	Siauliai
Lithuania	JSC Inlita Lazdynai CMC	Vilnius
Lithuania	JSC Inlita Santaros	Vilnius
Malaysia	Hospital Sultanah Bahiyah	Alor Setar
Malaysia	Hospital Universiti Kebangsaan Malaysia	Cheras	Kuala Lumpur
Malaysia	Hospital Raja Permaisuri Bainun Ipoh	Ipoh, Perak
Malaysia	Hospital Raja Perempuan Zainab II	Kota Bharu	Kelantan
Malaysia	Hospital Universiti Sains Malaysia_Kota Bharu, Kelantan	Kota Bharu	Kelantan
Malaysia	Sarawak Heart Centre	Kota Samarahan	Sarawak
Malaysia	National Heart Institute	Kuala Lumpur
Malaysia	University Malaya Medical Centre	Kuala Lumpur	Wilayah Persekutuan Kuala Lumpur
Malaysia	Hospital Seberang Jaya	Pulau Pinang
Malaysia	Hospital Queen Elizabeth II	Sabah
Malaysia	Hospital Miri	Sarawak
Malaysia	Hospital Tuanku Jaafar	Seremban
Malaysia	Hospital Seri Manjung	Seri Manjung	Perak
Malaysia	University Technology MARA (UiTM) - Puncak Alam	Sungai Buloh	Selangor
Malaysia	Hospital Sultan Abdul Halim	Sungai Petani	Kedah
Malaysia	Hospital Sultan Abdul Halim	Sungai Petani	Kedah
Mexico	Centro de Investigación Cardiometabólica de Aguascalientes	Aguascalientes
Mexico	Hospital Angeles de Culiacan	Culiacan	Sinaloa
Mexico	Centro para el Desarrollo de la Medicina y la Asistencia	Culiacán	Sinaloa
Mexico	Centro de Investigacion Clinica Endocrinologica de Jalisco	Guadalajara	Jalisco
Mexico	Consultorio Privado	Guadalajara	Jalisco
Mexico	Clínicos Asociados BOCM, S.C.	Mexico City	México, D.F.
Mexico	Cardiolink Clin Trials S.C.	Monterrey	Nuevo Leon
Mexico	Internal Medicine Clin Trials	Monterrey	Nuevo León
Mexico	Unidad Biomedica Avanzada Monterrey	Monterrey	Nuevo León
Mexico	Centro de Estudios Clínicos de Querétaro S.C.	Queretaro
Mexico	Centro de atención e investigación cardiovascular del Potosí	San Luis Potosí	San Luis Potosi
Mexico	CINCAME	Tijuana	Baja California
Mexico	FAICIC S. de R.L. de C.V.	Veracruz
Netherlands	Noordwest Ziekenhuisgroep	Alkmaar
Netherlands	Noordwest Ziekenhuisgroep	Alkmaar
Netherlands	Ziekenhuis Groep Twente Almelo	Almelo
Netherlands	Ziekenhuis Groep Twente Almelo	Almelo
Netherlands	Academisch Medisch Centrum	Amsterdam
Netherlands	Academisch Medisch Centrum	Amsterdam
Netherlands	Gelre Ziekenhuizen Apeldoorn	Apeldoorn
Netherlands	Gelre Ziekenhuizen Apeldoorn	Apeldoorn
Netherlands	Amphia Ziekenhuis	Breda
Netherlands	St Jansdal	Harderwijk
Netherlands	Tergooi, locatie Hilversum	Hilversum
Netherlands	Leids Universitair Medisch Centrum	Leiden
Netherlands	Bravis Ziekenhuis	Roosendaal
Netherlands	Ikazia Ziekenhuis	Rotterdam
Netherlands	D & A Research B.V.	Sneek
Netherlands	D & A Research B.V.	Sneek
Netherlands	Zaans Medisch Centrum	Zaandam
Poland	Kresmed Sp. z o. o.	Bialystok	Podlaskie
Poland	Kresmed Sp. z o. o.	Bialystok	Podlaskie
Poland	Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio	Bialystok	Podlaskie
Poland	Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio	Bialystok	Podlaskie
Poland	Malopolskie Centrum Sercowo-Naczyniowe	Chrzanow	Malopolskie
Poland	Centrum Kliniczno Badawcze	Elblag
Poland	Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman	Gdynia
Poland	Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski	Gorzow Wielkopolski	Lubuskie
Poland	Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II	Grodzisk Mazowiecki
Poland	Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET	Krakow	Malopolskie
Poland	Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET	Krakow	Malopolskie
Poland	Praktyka Lekarska Mateusz Sidor	Krakow
Poland	Specjalistyczna Praktyka Lekarska L. Bryniarski	Krakow
Poland	Krakowski Szpital Specjalistyczny im. Jana Pawla II	Kraków
Poland	Centrum Terapii Wspolczesnej	Lodz
Poland	Instytut Centrum Zdrowia Matki Polki	Lodz
Poland	Salve Medica	Lodz
Poland	Uniwersytecki Szpital Kliniczny Im Wojskowej Akademii Medycznej Centralny Szpital Weteranow	Lodz	Lodzkie
Poland	NZOZ "CenterMed Lublin" Sp. z o.o.	Lublin	Lubelskie
Poland	Specjalistyczna Praktyka Lekarska w Ogrodziencu ul. Plac Wolnosci 23, 42-440 Ogrodzieniec	Ogrodzieniec
Poland	ETG Poniatowa	Poniatowa	Lublin Province
Poland	Uniwersytecki Szpital Kliniczny W Poznaniu	Poznan
Poland	Velocity Nova Sp. z o.o.	Pulawy
Poland	Aka-Med Centrum	Ruda Slaska	Silesian Voivodeship
Poland	Aka-Med Centrum	Ruda Slaska	Silesian Voivodeship
Poland	CENTRUM MEDYCZNE VITA Praktyka Kardiologiczna	Szczecin
Poland	Polsko - Amerykanskie Kliniki Serca X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach	Tychy
Poland	Polsko - Amerykanskie Kliniki Serca X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach	Tychy
Poland	I Katedra i Klinika Kardiologii WUM SPCSK	Warsaw
Poland	Narodowy Instytut Kardiologii Klin. Kard. i Ang.	Warszawa
Poland	Narodowy Instytut Kardiologii Klin. Kard. i Ang.	Warszawa
Poland	Narodowy Instytut Kardiologii Klin. Kard. i Transp.	Warszawa
Poland	NBR Polska Tomasz Klodawski	Warszawa
Poland	Szpital Powiatowy Im. Hrabiego Stanislawa Lubienskiego Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Wegrowie	Wegrow
Poland	Praktyka Lekarska-Tomasz Borkowski	Wloclawek	Kujawsko-pomorskie
Poland	4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu	Wroclaw	Dolnoslaskie
Poland	Centrum Badan Klinicznych	Wroclaw
Poland	Centrum Badan Klinicznych	Wroclaw
Poland	Zdrowie S.C. Agnieszka I Donald Drozdz	Wroclaw	Dolnoslaskie
Poland	Velocity Zamosc	Zamosc
Portugal	Hospital Garcia de Orta	Almada
Portugal	Hospital Infante D. Pedro - Aveiro	Aveiro
Portugal	Hospital de Braga	Braga
Portugal	Hospital Santa Cruz	Carnaxide
Portugal	Centro Hospitalar e Universitário de Coimbra	Coimbra
Portugal	CHTâmega e Sousa - Hospital Padre Américo	Guilhufe - Penafiel
Portugal	APDP - Associação Protectora dos Diabéticos de Portugal	Lisboa
Portugal	Centro Hospitalar Lisboa Norte	Lisboa
Portugal	CHLO, EPE - Hospital São Francisco Xavier	Lisbon
Portugal	Unidade Local de Saúde de Matosinhos	Matosinhos
Portugal	Centro Hospitalar de São João	Porto
Portugal	Centro Hospitalar de Setubal	Setubal
Portugal	Unidade Local de Saúde do Alto Minho - Viana do Castelo	Viana do Castelo
Portugal	Centro Hospitalar Vila Nova de Gaia/Espinho, EPE	Vila Nova de Gaia
Romania	Cabinet Medical de Cardiologie Dr. Calin Pop	Baia Mare
Romania	Spitalul Jude?ean de Urgen?a Braila	Braila
Romania	Spitalul Jude?ean de Urgen?a Braila	Braila
Romania	Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed	Brasov
Romania	S.C. Centrul Medical Unirea S.R.L.	Brasov
Romania	Davius Clinicmed Srl	Bucharest
Romania	Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila	Bucharest
Romania	Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila	Bucharest	Bucurestii
Romania	Centrul Medical Emerald	Bucuresti
Romania	Donna Medplus S.R.L.	Bucuresti
Romania	Hightech Medical Services S.R.L.	Bucuresti
Romania	Institutul Clinic Fundeni	Bucuresti	Bucharest
Romania	Lotus Med SRL	Bucuresti
Romania	Spitalul Clinic de Urgenta "Sf. Ioan" Bucuresti	Bucuresti
Romania	Spitalul Universitar de Urgen?a Elias	Bucuresti
Romania	Spitalul Universitar de Urgenta Bucuresti	Bucuresti
Romania	Mat Cord Biomedica S.R.L.	Buzau
Romania	Clinic of Diabetes Cluj	Cluj Napoca	Cluj
Romania	Clinic of Diabetes Cluj	Cluj Napoca	Cluj
Romania	Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta	Constanta
Romania	Cardiomed SRL	Craiova
Romania	Cardiomed SRL	Craiova
Romania	Neurocord Medical SRL	Craiova
Romania	SC Diamed Obesity SRL	Galati
Romania	Institutul de Boli Cardiovasculare "Prof. Dr. George I.M. Georgescu"	Iasi
Romania	SC Cardiomed SRL	Iasi
Romania	SC Consultmed SRL	Iasi
Romania	Spitalul Clinic Judetean De Urgenta Bihor	Oradea
Romania	Bella Praxis S.R.L.	Pascani
Romania	Sc Sal Med Srl	Pitesti
Romania	Spitalul Clinic Judetean de Urgenta Targu Mures	Targu Mures
Romania	Institutul de Boli Cardiovasculare Timisoara	Timisoara
Romania	Spitalul Clinic Municipal de Urgenta Timisoara	Timisoara
Romania	CMI Dr. Cristian Podoleanu	Tirgu Mures
Russian Federation	RBSHI "Altay Regional Cardiology Dispensary"	Barnaul
Russian Federation	RBSHI "Altay Regional Cardiology Dispensary"	Barnaul
Russian Federation	Reg. State Budget Healthc. Inst. Regional Clinical Hospital	Barnaul
Russian Federation	Road Clinical Hospital at station Chelyabinsk	Chelyabinsk
Russian Federation	Road Clinical Hospital at station Chelyabinsk	Chelyabinsk
Russian Federation	Chita State Medical Academy	Chita
Russian Federation	Irkutsk State Medical Academy of Postgraduate Education	Irkutsk
Russian Federation	Irkutsk State Medical Academy of Postgraduate Education	Irkutsk
Russian Federation	FSB EI "Kazan' State Medical University"	Kazan
Russian Federation	FSB EI "Kazan' State Medical University"	Kazan
Russian Federation	SAI of Health "Interregional Clinic Diagnostic Center"	Kazan
Russian Federation	Institute of Complex Problems of Cardio-Vascular Diseases	Kemerovo
Russian Federation	Friendship University of Russia MCCH base	Moscow
Russian Federation	Friendship University of Russia MCCH base	Moscow
Russian Federation	National Medical Research Center of Cardiology	Moscow
Russian Federation	Pirogov Russian National Research Medical University MoH	Moscow
Russian Federation	Pirogov Russian National Research Medical University MoH	Moscow
Russian Federation	Limited Law Company "Healthy Family" Medicine Center"	Novosibirsk
Russian Federation	LLC RC Medical	Novosibirsk
Russian Federation	State Novosibirsk regional clinical hospital	Novosibirsk
Russian Federation	State Novosibirsk regional clinical hospital	Novosibirsk
Russian Federation	SBIH Perm region "City Clinical Hospital #2 n.a. F.K. Gral"	Perm
Russian Federation	Republican Hospital n.a. V. A. Baranov	Petrozavodsk
Russian Federation	Medical Research Institute LLC	Saint Petersburg
Russian Federation	SPb BHI "City Pokrovskaya Hospital"	Saint-Petersburg
Russian Federation	Regional Clinical cardiological dispensary n.a. Polyakov	Samara
Russian Federation	City Hospital #4, Sochi	Sochi
Russian Federation	City Hospital #4, Sochi	Sochi
Russian Federation	Tomsk National Research Medical Center of the RAS	Tomsk
Russian Federation	Tomsk National Research Medical Center of the RAS	Tomsk
Serbia	CHC Zvezdara, Clinical department for endocrinology	Belgrade
Serbia	Clinical centre of Serbia, Clinic for cardiology	Belgrade
Serbia	Clinical Centre of Serbia, Emergency Centre, Department of Cardiology	Belgrade
Serbia	Clinical Hospital Centre Zemun	Belgrade
Serbia	Emergency Internal Medicine Clinic	Belgrade
Serbia	Endocrinology, Diabetes and Metabolism Diseases Clinic	Belgrade
Serbia	Endocrinology, Diabetes and Metabolism Diseases Clinic	Belgrade
Serbia	Institute for Cardiovascular Diseases ''Dedinje''	Belgrade
Serbia	Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department	Kragujevac
Serbia	University Clinical Centre Nis, Clinic for Cardiology	Nis
Serbia	Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.	Novi Sad	Vojvodina
Serbia	Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica	Sremska Kamenica
Serbia	Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica	Sremska Kamenica
Slovakia	1. Interna klinika SZU a UNB	Bratislava
Slovakia	CARDIOCONSULT, s.r.o.	Bratislava
Slovakia	CINRE s. r. o., Oddelenie akutnej kardiologie a koronarna JIS	Bratislava
Slovakia	DIABEDA s.r.o.	Bratislava
Slovakia	I. Interna klinika LF UK a UNB	Bratislava
Slovakia	Klinika kardiologie a angiologie LF SZU	Bratislava
Slovakia	Klinika kardiologie a angiologie LF SZU	Bratislava
Slovakia	Medical group Kosice s.r.o.	Kosice
Slovakia	VITAL, s.r.o.	Levice
Slovakia	Narodny Endokrinologicky a diabetologicky ustav	Lubochna
Slovakia	KARDIO 1, s.r.o., Kardiologicka ambulancia	Lucenec
Slovakia	1. interna klinika, Univerzitna nemocnica Martin	Martin
Slovakia	1. interna klinika, Univerzitna nemocnica Martin	Martin
Slovakia	InterStom, s.r.o.	Nitra
Slovakia	InterStom, s.r.o.	Nitra
Slovakia	Kardiologicka ambulancia, KARDIOMED NZ, s.r.o.	Nove Zamky
Slovakia	Medical KG, s.r.o.	Piestany
Slovakia	Kardiologicka ambulancia	Povazska Bystrica
Slovakia	FNsP J. A. Reimana Presov, Klinika kardiologie	Presov
Slovakia	IMCORE, s.r.o.	Presov
South Africa	Cardiology Research_Bloemfontein	Bloemfontein	Free State
South Africa	IATROS International	Bloemfontein	Free State
South Africa	Josha Research	Bloemfontein	Free State
South Africa	Josha Research	Bloemfontein	Free State
South Africa	Helderberg Research Institute	Cape Town	Western Cape
South Africa	Helderberg Research Institute	Cape Town	Western Cape
South Africa	Prof Rayner	Cape Town	Western Cape
South Africa	Synexus Helderberg Clinical Research Centre	Cape Town	Western Cape
South Africa	Tiervlei Trial Centre	Cape Town	Western Cape
South Africa	Tread Research (Pty)Ltd	Cape Town	Western Cape
South Africa	Dr Iftikhar Osman Ebrahim	Centurion	Gauteng
South Africa	Excellentis Clinical Trial Consultants	George	Eastern Cape
South Africa	TASK Eden Clinical Research Centre	George	Western Cape
South Africa	Tickerdoc Research (Pty) LTD	Johannesburg	Gauteng
South Africa	Tickerdoc Research (Pty) LTD	Johannesburg	Gauteng
South Africa	Wits Bara Clinical Trial Site	Johannesburg	Gauteng
South Africa	WITS Clinical Research	Johannesburg	Gauteng
South Africa	Dr Hendrik Snyman's Practice	Mossel Bay	Western Cape
South Africa	Paarl Research Centre	Paarl	Western Cape
South Africa	Paarl Reserch Centre	Paarl	Western Cape
South Africa	Clinical Trial Systems (CTC)	Pretoria	Gauteng
South Africa	EMMED Clinical Research	Pretoria	Gauteng
South Africa	Jongaie Research	Pretoria	Gauteng
South Africa	Synexus Watermeyer Clinical Research Centre	Pretoria	Gauteng
South Africa	Roodepoort Medicross Clinical Research Centre	Roodepoort	Gauteng
South Africa	Mediclinic Medical Centre	Tongaat	KwaZulu-Natal
Spain	Hospital Universitario de Cruces	Baracaldo
Spain	Hospital Vithas Sevilla	Castilleja Dela Cuesta Sevilla
Spain	Hospital Reina Sofia	Córdoba
Spain	Hospital Reina Sofia	Córdoba
Spain	Hospital Virgen de la Arrixaca	El Palmar	Murcia
Spain	Bellvitge Universitary Hospital	L' Hospitalet Del Llobregat
Spain	Bellvitge Universitary Hospital	L' Hospitalet Del Llobregat
Spain	Hospital Universitario Puerta de Hierro Majadahonda	Majadahonda	Madrid
Spain	Hospital Virgen del Camino - Sanlúcar de Barrameda	Sanlúcar de Barrameda
Spain	Hospital Clínico Universitario de Valencia	Valencia
Spain	Hospital Clínico Universitario de Valencia	Valencia
Spain	Hospital Universitario Doctor Peset	Valencia
Spain	Hospital Universitario Doctor Peset	Valencia
Spain	Hospital Virgen de las Montañas	Villamartin
Spain	Hospital Universitario Miguel Servet	Zaragoza
Sweden	Njurmedicin	Göteborg
Sweden	Huddinge Tema hjärta kärl	Huddinge	Stockholm
Sweden	Clemenstorgets Hjärtmottagning	Lund
Sweden	Forskningsmottagning Internmedicin (tidigare KFE)	Malmö
Sweden	Njursektionen Medicinkliniken Örebro University Hospital	Örebro
Sweden	Karolinska Universitetssjukhuset Solna,FOU Tema Hjärta Kärl	Stockholm
Sweden	Forskning njurmedicin Uppsala	Uppsala
Taiwan	HsinChu MacKay Memorial Hospital	Hsinchu City
Taiwan	E-DA Hosiptal	Kaohsiung City
Taiwan	Kaohsiung Medical University Chung-Ho Memorial Hospital	Kaoshiung
Taiwan	National Cheng Kung University Hospital	Tainan
Taiwan	Chi Mei Medical Center	Tainan City
Taiwan	Cheng Hsin General Hospital	Taipei
Taiwan	National Taiwan University Hospital	Taipei
Taiwan	Taipei Veterans General Hospital	Taipei
Taiwan	Taipei Medical University Hospital	Taipei city
Taiwan	Chang Gung Memorial Hospital Linkou	Taoyuan City
Taiwan	National Yang Ming Chiao Tung University Hospital Lanyang Campus	Yilan City
Thailand	Cardio-Vajira	Bangkok
Thailand	Chulabhorn hospital	Bangkok
Thailand	King Chulalongkorn Memorial Hospital	Bangkok
Thailand	Phramongkutklao Hospital-nephrology	Bangkok
Thailand	Ramathibodi Hospital	Bangkok	Thung Phayathai Subdistrict
Thailand	Siriraj Hospital	Bangkok
Thailand	Siriraj Hospital	Bangkok Noi	Bangkok
Thailand	Siriraj Hospital	Bangkok Noi	Bangkok
Thailand	Maharaj Nakorn Chiang Mai Hospital	Chiang Mai	Mueang Chiang Mai District
Thailand	Maharaj Nakorn Chiang Mai Hospital	Chiang Mai
Thailand	Research Institute for Health Sciences, CMU	Chiang Mai
Thailand	Songklanagarind Hospital	Hat Yai	Songkla
Thailand	Songklanagarind Hospital	Hat Yai	Songkla
Thailand	Srinagarind Hospital	Khon Kaen
Thailand	Thammasat University Hospital	Klong Luang, Pathumthani	Pathumthani
Thailand	Maharat Nakhon Ratchasima Hospital	Mueang Nakhon Ratchasima	Nakhon Ratchasima
Thailand	Sunpasitthiprasong Hospital	Ubon Ratchathani
Turkey	Afyonkarahisar Health Sciences University	Afyon
Turkey	Ankara Sehir Hastanesi Cardiology	Ankara
Turkey	Hacettepe Universitesi Tip Fakultesi Nefroloji Bilim Dali	Ankara
Turkey	Hacettepe University Medical Faculty_Ankara	Ankara
Turkey	Akdeniz Universitesi Hastanesi Nefroloji Bilim Dali	Antalya
Turkey	Aydin Adnan Menderes University Nephrology	Aydin
Turkey	Trakya University	Edirne
Turkey	Eskisehir Osmangazi University-Cardio	Eskisehir
Turkey	Dr. Siyami Ersek Gogus Kalp ve Damar Cerrahisi EAH	Istanbul
Turkey	Istanbul Florence Nightingale Hospital	Istanbul
Turkey	Istanbul University Cardiology Institute	Istanbul
Turkey	Istanbul University Cerrahpasa Medical Faculty	Istanbul	Bakirkoy
Turkey	Dokuz Eylul University School of Medicine, Cardiology	Izmir
Turkey	Ege University School of Medicine, Cardiology Department	Izmir
Turkey	Kahramanmaras Sutcu Imam University	Kahramanmaras
Turkey	Erciyes University Medial Faculty	Kayseri
Turkey	Kocaeli University Nephrology Department	Kocaeli
Turkey	Mersin University Cardiology	Mersin
Turkey	Mugla Sitki Kocman University Medical Faculty	Mugla
Ukraine	Reg Clin Hospital of Emergency Care, Bukovinian Medical Univ	Chernivtsi
Ukraine	Reg Clin Hospital of Emergency Care, Bukovinian Medical Univ	Chernivtsi
Ukraine	Clinical medical diagnostic center "Simedgroup"	Ivano-Frankivsk
Ukraine	CNPI "Kharkiv City Clinical Hospital #27"	Kharkiv
Ukraine	Municipal Non-Profit Institution "City Clinical Hospital #8"	Kharkiv
Ukraine	Municipal Non-Profit Institution "City Clinical Hospital #8"	Kharkiv
Ukraine	NI of Therapy na LT Malaya of NAMSU - Chr. Non-Communicable	Kharkiv
Ukraine	NI of Therapy na LT Malaya of NAMSU - Chr. Non-Communicable	Kharkiv
Ukraine	"M.D. Strazhesko Institute of Cardiology"	Kyiv
Ukraine	Center of Family Medicine Plus LLC	Kyiv
Ukraine	Clinical Hosp on the railway line ?2 branch PHC JSC Ukrzaliz	Kyiv
Ukraine	Kyiv City Clinical Hospital of Emergency Care - Infarction	Kyiv
Ukraine	Kyiv Regional Hospital	Kyiv
Ukraine	MD Strazheska Institute of Cardiology of NAMSU - Resuscitati	Kyiv
Ukraine	Medbud-Clinic LLC	Kyiv
Ukraine	Medical Center 'CONSILIUM MEDICAL'	Kyiv
Ukraine	Medical Center 'Ok!Clinic+' of II of Clinical Studies LLC	Kyiv
Ukraine	CI "Zaporizhia city clinical hospital #10"	Zaporizhia
Ukraine	ERMC"University Hospital" of Zaporizhzhia State Med Univer	Zaporizhzhia
Ukraine	Central City Hospital #1 - Scientific-Research center	Zhytomyr
United Kingdom	Crouch Oak Family Practice	Addlestone	Surrey
United Kingdom	Barnet Hospital	Barnet
United Kingdom	Sandwell General Hospital	Birmingham
United Kingdom	Blackpool Victoria Hospital	Blackpool	Lancashire
United Kingdom	Bradford Royal Infirmary	Bradford
United Kingdom	The Health Centre	Bradford-on-Avon
United Kingdom	Southmead Hospital	Bristol
United Kingdom	Addenbrooke's Hospital	Cambridge
United Kingdom	Lakeside Healthcare Research & Innovation Unit	Corby	Northamptonshire
United Kingdom	Kings College Hospital	Denmark Hill, London
United Kingdom	Dorset County Hospital	Dorchester	Dorset
United Kingdom	Royal Bournemouth Hospital	Dorset
United Kingdom	The Adam Practice	Dorset
United Kingdom	Carmel Medical Practice	Durham
United Kingdom	Royal Devon University Healthcare NHS Foundation Trust	Exeter
United Kingdom	Wycombe General Hospital	High Wycombe
United Kingdom	Sherbourne Medical Centre	Leamington Spa
United Kingdom	Cardiology	Leicester
United Kingdom	Leicester General Hospital	Leicester
United Kingdom	Lincoln County Hospital	Lincoln
United Kingdom	Liverpool Heart & Chest Hospital	Liverpool
United Kingdom	University Hospital Aintree	Liverpool
United Kingdom	University Hospital Aintree	Liverpool
United Kingdom	William Harvey Clinical Research Centre	London
United Kingdom	William Harvey Clinical Research Centre	London
United Kingdom	Freeman Hospital, Newcastle	Newcastle Upon Tyne
United Kingdom	John Radcliffe Hospital	Oxford
United Kingdom	Pickering Medical Practice	Pickering
United Kingdom	Panthera Biopartners Preston	Preston
United Kingdom	Ashfields Primary Care Centre	Sandbach	Cheshire
United Kingdom	Lister Hospital	Stevenage
United Kingdom	Lister Hospital	Stevenage
United Kingdom	University of North Tees Hospital	Stockton-on-Tees
United Kingdom	Musgrove Park Hospital	Taunton
United Kingdom	Cardiology Department	Torquay
United Kingdom	Albany House Medical Centre	Wellingborough
United Kingdom	St. Richards Hospital	West Sussex
United States	Javara/Privia Med Grp GA,LLC	Albany	Georgia
United States	Uni of New Mexico-Clinical	Albuquerque	New Mexico
United States	Anne Arundel Medical Center	Annapolis	Maryland
United States	Arlington Family Res. Ctr Inc	Arlington	Texas
United States	Liberty Research Center	Arlington	Texas
United States	Northwest Heart Clinical Research, LLC	Arlington Heights	Illinois
United States	Mountain Kidney & Hypertension Associates	Asheville	North Carolina
United States	Southeastern Clinical Research Institute, LLC	Augusta	Georgia
United States	Southeastern Clinical Research Institute, LLC	Augusta	Georgia
United States	Novel Research LLC	Bellaire	Texas
United States	Suburban Hospital	Bethesda	Maryland
United States	Northeast Clinical Research Center	Bethlehem	Pennsylvania
United States	National Heart Institute Cal	Beverly Hills	California
United States	Uni of Alabama at Birmingham	Birmingham	Alabama
United States	Excel Med Ctr Clinical Trials	Boca Raton	Florida
United States	Grace Research, LLC	Bossier City	Louisiana
United States	Brigham & Women's Hospital	Boston	Massachusetts
United States	Bridgeport Hospital	Bridgeport	Connecticut
United States	Bridgeport Hospital	Bridgeport	Connecticut
United States	Advanced Heart Care LLC	Bridgewater	New Jersey
United States	DaVita Clinical Research - New York	Bronx	New York
United States	Kernodle Clin Dpt-Pvt Diagnost	Burlington	North Carolina
United States	UNC- Chapel Hill	Chapel Hill	North Carolina
United States	Javara Inc._Charlotte	Charlotte	North Carolina
United States	Metrolina Nephrology Associates, PA	Charlotte	North Carolina
United States	Univ Diab & Endo Consultants	Chattanooga	Tennessee
United States	Research by Design LLC	Chicago	Illinois
United States	Research by Design LLC	Chicago	Illinois
United States	California Inst Of Renal Res	Chula Vista	California
United States	University of Cincinnati Medical Center (UCMC)	Cincinnati	Ohio
United States	Innovative Research of W Florida Inc.	Clearwater	Florida
United States	VA Northeast Ohio Healthcare System (VANEOHS)	Cleveland	Ohio
United States	John P Hakim MD and Associates	Clinton	Maryland
United States	John P Hakim MD and Associates	Clinton	Maryland
United States	Hope Clin Res & Wellness	Conyers	Georgia
United States	Osvaldo A. Brusco MD PA	Corpus Christi	Texas
United States	Valley Clinical Trials	Covina	California
United States	Research Trials Worldwide LLC	Cypress	Texas
United States	Liberty Research Center_Dallas	Dallas	Texas
United States	Renal Disease Research Institute	Dallas	Texas
United States	Thyroid Endocrinology & Diabetes PA	Dallas	Texas
United States	Florida Premier Cardiology	Delray Beach	Florida
United States	Denver Health Outpatient Medical Center	Denver	Colorado
United States	Henry Ford Hospital_Detroit	Detroit	Michigan
United States	DHR Health Inst for Res & Dev	Edinburg	Texas
United States	Academy of Diabetes, Thyroid & Endocrine, P.A.	El Paso	Texas
United States	MediSphere Medical Research Center, LLC	Evansville	Indiana
United States	Lillestol Research LLC	Fargo	North Dakota
United States	Lillestol Research LLC	Fargo	North Dakota
United States	Javara Inc._Albany	Fayetteville	Georgia
United States	Northeast Research Institute	Fleming Island	Florida
United States	Elite Research Center	Flint	Michigan
United States	Javara Inc/Privia Md GpLLC Fst	Forest	Virginia
United States	Care United Research, LLC	Forney	Texas
United States	Integrative Research Assoc Inc	Fort Lauderdale	Florida
United States	Piedmont Research Partners, LLC	Fort Mill	South Carolina
United States	Diabetes and Thyroid Ctr of FW	Fort Worth	Texas
United States	Javara /TX.Hlth LLC dba Prvia	Fort Worth	Texas
United States	Lenzmeier Fam Med CCT Research	Glendale	Arizona
United States	Healthy Heart Cardiology	Grand Rapids	Michigan
United States	Balad Hlth Sys-Welmont CardCVA	Greeneville	Tennessee
United States	PharmQuest Life Sciences LLC	Greensboro	North Carolina
United States	Palmetto Clinical Research	Greenville	South Carolina
United States	Palmetto Clinical Research	Greenville	South Carolina
United States	Physicians East Endocrinology	Greenville	North Carolina
United States	Physicians East Endocrinology	Greenville	North Carolina
United States	Clinical Invest Special_Gurnee	Gurnee	Illinois
United States	Pentucket Medical Associates	Haverhill	Massachusetts
United States	Chicago Medical Research LLC	Hazel Crest	Illinois
United States	Elixia Pines	Hollywood	Florida
United States	Encore Medical Research LLC	Hollywood	Florida
United States	Baylor College Of Medicine_Houston	Houston	Texas
United States	Biopharma Informatic, LLC	Houston	Texas
United States	Biopharma Informatic_Houston	Houston	Texas
United States	Biopharma Informatic_Houston_0	Houston	Texas
United States	Cardiovasc Spec of Willowbrook	Houston	Texas
United States	PlanIt Research, PLLC	Houston	Texas
United States	PlanIt Research, PLLC	Houston	Texas
United States	PrimeCare Medical Group	Houston	Texas
United States	Prolato Clinical Research Center	Houston	Texas
United States	Prolato Clinical Research Center	Houston	Texas
United States	Valiance Clinical Research	Huntington Park	California
United States	Baptist Heart Specialists	Jacksonville	Florida
United States	Est Cst Inst for Rsrch,Jksnvil	Jacksonville	Florida
United States	Northeast Research Institute	Jacksonville	Florida
United States	NSC Research, Inc	Johns Creek	Georgia
United States	Clinical Research Consultants, LLC	Kansas City	Missouri
United States	Tennova Healthcare-Turkey Creek Medical Center	Knoxville	Tennessee
United States	Scripps Wht Diab Inst La Jolla	La Jolla	California
United States	Balboa Nephro Med Gr Inc LaMes	La Mesa	California
United States	First Valley Medical Group	Lancaster	California
United States	Palm Research Center Inc-Vegas	Las Vegas	Nevada
United States	University of Nevada School of Medicine	Las Vegas	Nevada
United States	Lexington VA Health Care System	Lexington	Kentucky
United States	The Research Group of Lexington LLC	Lexington	Kentucky
United States	Nebraska Heart Institute_Lincoln	Lincoln	Nebraska
United States	Ocean St Clin Res Partnrs, LLC	Lincoln	Rhode Island
United States	Univ of Arkansas Med Sciences	Little Rock	Arkansas
United States	VA Loma Linda Hlthcr Sys	Loma Linda	California
United States	DCOL Ctr for Clin Res	Longview	Texas
United States	Pacific Clinical Studies	Los Alamitos	California
United States	Angel City Research, Inc.	Los Angeles	California
United States	Norton Heart Specialists-Springs	Louisville	Kentucky
United States	Texas Inst, Kdny & Endo Disor	Lufkin	Texas
United States	North America Research Institute	Lynwood	California
United States	Advanced Med Res Maumee	Maumee	Ohio
United States	RGV Endocrine Center	McAllen	Texas
United States	Clinical Neuroscience Solutions	Memphis	Tennessee
United States	Aventiv Research Inc.	Mesa	Arizona
United States	Allied Biomedical Research	Miami	Florida
United States	Life Spring Research	Miami	Florida
United States	Pharmax Research Clinic	Miami	Florida
United States	San Marcus Res Clin Miami Lakes	Miami Lakes	Florida
United States	NYU Nephrology Associates	Mineola	New York
United States	AHS dba Abbot NW Hosp Diab Cen	Minneapolis	Minnesota
United States	University of Minnesota_Minneapolis_1	Minneapolis	Minnesota
United States	Office of Kenneth Blaze DO	Miramar	Florida
United States	Clinical Trials of Ame, LLC	Monroe	Louisiana
United States	IMA Clinical Research	Monroe	Louisiana
United States	Healthscan Clinical Trials,LLC.	Montgomery	Alabama
United States	Carteret Medical Group	Morehead City	North Carolina
United States	Family Medicine of SayeBrook LLC	Myrtle Beach	South Carolina
United States	Saltzer Medical Group Research	Nampa	Idaho
United States	Suncoast Clin Res Port Richey	New Port Richey	Florida
United States	Mount Sinai Hosp at NYC	New York	New York
United States	NYU Grossman School of Med	New York	New York
United States	NYU Grossman School of Med	New York	New York
United States	Hoag Medical Group	Newport Beach	California
United States	York Clinical Research LLC	Norfolk	Virginia
United States	Northport VA Med Ctr Northport	Northport	New York
United States	Valley Clinical Trials, Inc.	Northridge	California
United States	Methodist Phys Clin Heart Cons	Omaha	Nebraska
United States	Univ of Nebraska Medical CTR	Omaha	Nebraska
United States	VA NEB - Western IA Health Stm	Omaha	Nebraska
United States	Midwest Heart & Vasc Spec	Overland Park	Kansas
United States	Suncoast Clinical Research, Inc.	Palm Harbor	Florida
United States	Desert Oasis Hlthcr Med Group	Palm Springs	California
United States	Desert Oasis Hlthcr Med Group	Palm Springs	California
* Note: There are 1057 locations in all - only the first 1000 are shown.

Sponsors (1)

Lead Sponsor	Collaborator
Novo Nordisk A/S

Countries where clinical trial is conducted

United States,  Argentina,  Australia,  Belgium,  Brazil,  Bulgaria,  Canada,  China,  Croatia,  Czechia,  Denmark,  Germany,  Greece,  Hungary,  India,  Israel,  Italy,  Japan,  Korea, Republic of,  Latvia,  Lithuania,  Malaysia,  Mexico,  Netherlands,  Poland,  Portugal,  Romania,  Russian Federation,  Serbia,  Slovakia,  South Africa,  Spain,  Sweden,  Taiwan,  Thailand,  Turkey,  Ukraine,  United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time to first occurrence of 3-point Major Adverse Cardiovascular Event (MACE), a composite endpoint consisting of: Cardiovascular (CV) death, non-fatal Myocardial Infarction (MI) and non-fatal stroke	Months	From randomisation (month 0) to end-of-study (up to 48 months)
Secondary	Time to first occurrence of expanded MACE, a composite endpoint consisting of: CV death, non-fatal MI, non-fatal stroke and hospitalisation for unstable angina pectoris requiring urgent coronary revascularisation	Months	From randomisation (month 0) to end-of-study (up to 48 months)
Secondary	Number of heart failure hospitalisations or urgent heart failure visits or CV deaths	Count	From randomisation (month 0) to end-of-study (up to 48 months)
Secondary	Time to first occurrence of a composite kidney endpoint consisting of: CV death, onset of persistent atleast 40 percent (%) reduction in eGFR (CKD-epidemiology collaboration [CKD-EPI]) compared with baseline, kidney failure	Months	From randomisation (month 0) to end-of-study (up to 48 months)
Secondary	Time to occurrence of all-cause mortality	Months	From randomisation (month 0) to end-of-study (up to 48 months)
Secondary	Time to first occurrence of each of the individual components of the expanded MACE endpoint and the kidney composite endpoint.	Months	From randomisation (month 0) to end-of-study (up to 48 months).
Secondary	Time to first occurrence of MI (fatal and non-fatal).	Months	From randomisation (month 0) to end-of-study (up to 48 months).
Secondary	Time to first occurrence of stroke (fatal and non-fatal).	Months	From randomisation (month 0) to end-of-study (up to 48 months).
Secondary	Time to first occurrence of a composite MACE endpoint consisting of: all-cause mortality, non-fatal MI and non-fatal stroke	Months	From randomisation (month 0) to end-of-study (up to 48 months).
Secondary	Time to first occurrence of a 4-component kidney endpoint consisting of: onset of persistent at least 40% reduction in eGFR (CKD-EPI) compared with baseline, kidney failure	Months	From randomisation (month 0) to end-of-study (up to 48 months).
Secondary	Time to first occurrence of coronary revascularisation	Months	From randomisation (month 0) to end-of-study (up to 48 months).
Secondary	Change in Urinary Abumin-to-Ceatinine ratio (UACR).	Percentage	From randomisation (month 0) to 2 years (24 months).
Secondary	Change in eGFR (CKD-EPI))	mL/min/1.73 m^2	From randomisation (month 0) to 2 years (24 months)
Secondary	Annual rate of change in eGFR (CKD-EPI) (total eGFR slope)	mL/min/1.73 m^2/ year	From randomisation (month 0) to end-of-study (up to 48 months).
Secondary	Change in high-sensitivity C-reactive protein (hs-CRP)	Percentage	From randomisation (month 0) to 2 years (24 months
Secondary	Change in N-terminal-pro-brain natriuretic peptide ( NT-pro-BNP)	Percentage	From randomisation (month 0) to 2 years (24 months)
Secondary	Change in left ventricular ejection fraction (LVEF)	Percentage	From randomisation (month 0) to 2 years (24 months)
Secondary	Number of events of atrial fibrillation	Count	From randomisation (month 0) to end-of-study (up to 48 months).
Secondary	Change in haemoglobin	Grams per deciliter (g/dL)	From randomisation (month 0) to 2 years (24 months)
Secondary	Number of hospitalisations with infection as primary cause or death due to infection.	Count	From randomisation (month 0) to end-of-study (up to 48 months).
Secondary	Change in Short Form 36 (SF-36) Physical Component Score (PCS)	Score on scale	From randomisation (month 0) to 2 years (24 months)