Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections

Inflammation Clinical Trial

Official title:

Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections - A Retrospective Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04865003
• Other study ID #: 1208983
• Status: Completed
• Start date: January 1, 2014
• Est. completion date: December 31, 2020

Study information

• Verified date: April 2021
• Source: Clinical Center of Vojvodina
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections.

Description:

Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections. The study enrolled patients admitted to the Emergency Center of Vojvodina with the diagnosis of multispace DNI with or without DNM either as the primary diagnosis or with discharged diagnosis after surgical treatment during 7-years period. The data were obtained from patient medical records.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 289
• Est. completion date: December 31, 2020
• Est. primary completion date: December 31, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• patients admitted to the hospital due to deep neck infection affecting two or more spaces with or without descending necrotizing medioastinitis
• complete diagnosis and treatment data available from medical charts

Exclusion Criteria:

• incomplete medical data
• infection confined to one deep neck space
• patients treated under local anesthesia
• patients with superficial skin infections
• iatrogenic infections
• infected tumors

Related Conditions & MeSH terms

• Communicable Diseases
• Infection
• Inflammation
• Mediastinitis
• Neck Abscess

Intervention

Other:
• treatment of infection

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Clinical Center of Vojvodina

References & Publications (5)

Boscolo-Rizzo P, Da Mosto MC. Submandibular space infection: a potentially lethal infection. Int J Infect Dis. 2009 May;13(3):327-33. doi: 10.1016/j.ijid.2008.07.007. Epub 2008 Oct 25. — View Citation

Kimura A, Miyamoto S, Yamashita T. Clinical predictors of descending necrotizing mediastinitis after deep neck infections. Laryngoscope. 2020 Nov;130(11):E567-E572. doi: 10.1002/lary.28406. Epub 2019 Nov 20. — View Citation

Prado-Calleros HM, Jiménez-Fuentes E, Jiménez-Escobar I. Descending necrotizing mediastinitis: Systematic review on its treatment in the last 6 years, 75 years after its description. Head Neck. 2016 Apr;38 Suppl 1:E2275-83. doi: 10.1002/hed.24183. Epub 20 — View Citation

Qu L, Xu H, Liang X, Cai X, Zhang W, Qian W. A Retrospective Cohort Study of Risk Factors for Descending Necrotizing Mediastinitis Caused by Multispace Infection in the Maxillofacial Region. J Oral Maxillofac Surg. 2020 Mar;78(3):386-393. doi: 10.1016/j.j — View Citation

Sarna T, Sengupta T, Miloro M, Kolokythas A. Cervical necrotizing fasciitis with descending mediastinitis: literature review and case report. J Oral Maxillofac Surg. 2012 Jun;70(6):1342-50. doi: 10.1016/j.joms.2011.05.007. Epub 2011 Aug 6. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of mediastinitis	Neck and chest computed tomography (CT)	Within 6 hours of admission
Secondary	Microbiological findings in DNI and DNM	Prevalence of microorganisms in mediastinitis	Within 1 week of admission
Secondary	Average number of hospital days	Comparison of average number of hospital days in DNI and DNM	Through study completion, an average of one month
Secondary	Incidence of complications	Complications among DNI and DNI+DNM groups	Within 30 days from admission
Secondary	Number of infected deep neck spaces	Neck and chest computed tomography (CT)	Within 6 hours of admission