Inflammation Clinical Trial
Official title:
Prognostic Factors for Descending Necrotizing Mediastinitis Development in Deep Space Neck Infections - A Retrospective Study
NCT number | NCT04865003 |
Other study ID # | 1208983 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | January 1, 2014 |
Est. completion date | December 31, 2020 |
Verified date | April 2021 |
Source | Clinical Center of Vojvodina |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Descending necrotizing mediastinitis (DNM) is the most serious complication of deep neck infections (DNI) with high mortality. The objective of this retrospective study was to evaluate possible prognostic factors for DNM development in deep space neck infections.
Status | Completed |
Enrollment | 289 |
Est. completion date | December 31, 2020 |
Est. primary completion date | December 31, 2020 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - patients admitted to the hospital due to deep neck infection affecting two or more spaces with or without descending necrotizing medioastinitis - complete diagnosis and treatment data available from medical charts Exclusion Criteria: - incomplete medical data - infection confined to one deep neck space - patients treated under local anesthesia - patients with superficial skin infections - iatrogenic infections - infected tumors |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Clinical Center of Vojvodina |
Boscolo-Rizzo P, Da Mosto MC. Submandibular space infection: a potentially lethal infection. Int J Infect Dis. 2009 May;13(3):327-33. doi: 10.1016/j.ijid.2008.07.007. Epub 2008 Oct 25. — View Citation
Kimura A, Miyamoto S, Yamashita T. Clinical predictors of descending necrotizing mediastinitis after deep neck infections. Laryngoscope. 2020 Nov;130(11):E567-E572. doi: 10.1002/lary.28406. Epub 2019 Nov 20. — View Citation
Prado-Calleros HM, Jiménez-Fuentes E, Jiménez-Escobar I. Descending necrotizing mediastinitis: Systematic review on its treatment in the last 6 years, 75 years after its description. Head Neck. 2016 Apr;38 Suppl 1:E2275-83. doi: 10.1002/hed.24183. Epub 20 — View Citation
Qu L, Xu H, Liang X, Cai X, Zhang W, Qian W. A Retrospective Cohort Study of Risk Factors for Descending Necrotizing Mediastinitis Caused by Multispace Infection in the Maxillofacial Region. J Oral Maxillofac Surg. 2020 Mar;78(3):386-393. doi: 10.1016/j.j — View Citation
Sarna T, Sengupta T, Miloro M, Kolokythas A. Cervical necrotizing fasciitis with descending mediastinitis: literature review and case report. J Oral Maxillofac Surg. 2012 Jun;70(6):1342-50. doi: 10.1016/j.joms.2011.05.007. Epub 2011 Aug 6. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Incidence of mediastinitis | Neck and chest computed tomography (CT) | Within 6 hours of admission | |
Secondary | Microbiological findings in DNI and DNM | Prevalence of microorganisms in mediastinitis | Within 1 week of admission | |
Secondary | Average number of hospital days | Comparison of average number of hospital days in DNI and DNM | Through study completion, an average of one month | |
Secondary | Incidence of complications | Complications among DNI and DNI+DNM groups | Within 30 days from admission | |
Secondary | Number of infected deep neck spaces | Neck and chest computed tomography (CT) | Within 6 hours of admission |
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