Inflammation Clinical Trial
— REACCTINGOfficial title:
Research on Emissions, Air Quality, Climate and Cooking Technologies in Northern Ghana
Verified date | November 2020 |
Source | University of Colorado, Boulder |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
REACCTING (Research on Emissions, Air quality, Climate, and Cooking Technologies in Northern Ghana) is an interdisciplinary randomized cookstove intervention study in the Kassena-Nankana District of Northern Ghana. The study tests two types of biomass burning stoves that have the potential to meet local cooking needs and represent different "rungs" in the cookstove technology ladder: a locally-made, low-tech Gyapa rocket stove and the imported, highly efficient Philips gasifier stove. Intervention households were randomized into four different groups, three of which received different combinations of two improved stoves, while the fourth group serves as a control for the duration of the study. Diverse measurements assess different points along the causal chain linking the intervention to final outcomes of interest. The investigators assess stove use and cooking behavior, cooking emissions, household air pollution and personal exposure, health burden, and local to regional air quality. Integrated analysis and modeling will tackle a range of interdisciplinary science questions, including examining ambient exposures among the regional population, assessing how those exposures might change with different technologies and behaviors, and estimating the comparative impact of local behavior and technological changes versus regional climate variability and change on local air quality and health outcomes.
Status | Completed |
Enrollment | 200 |
Est. completion date | December 31, 2017 |
Est. primary completion date | December 31, 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A to 55 Years |
Eligibility | Inclusion Individual Participants: - Classified as "rural" - Uses biofuel as main cooking fuel source (firewood, animal waste, crop residue/sawdust) - Uses borehole as main water source (to facilitate social network analysis linking household's knowledge and attitudes toward stoves to experience of social contacts); - Does not have electricity (to permit possible addition of lighting intervention at a later date); - Has a woman in household aged 18-55 and at least one child under five (since women and children are the most vulnerable to cookstove smoke and are thus the main focus of our health measures). Clusters: - No more than 25% classified as urban - Accessible year-round (determined by field staff) - Having at least 10 eligible households (in line with the participant criteria above) Exclusion: - Household could not be located - Household declined to participate |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University of Colorado, Boulder | Environmental Protection Agency (EPA), U.S. National Science Foundation |
Dickinson KL, Kanyomse E, Piedrahita R, Coffey E, Rivera IJ, Adoctor J, Alirigia R, Muvandimwe D, Dove M, Dukic V, Hayden MH, Diaz-Sanchez D, Abisiba AV, Anaseba D, Hagar Y, Masson N, Monaghan A, Titiati A, Steinhoff DF, Hsu YY, Kaspar R, Brooks B, Hodgson A, Hannigan M, Oduro AR, Wiedinmyer C. Research on Emissions, Air quality, Climate, and Cooking Technologies in Northern Ghana (REACCTING): study rationale and protocol. BMC Public Health. 2015 Feb 12;15:126. doi: 10.1186/s12889-015-1414-1. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Health (Biomarkers of inflammation) | Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha). | At baseline | |
Primary | Health (Biomarkers of inflammation) | Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha). | At 6 months | |
Primary | Health (Biomarkers of inflammation) | Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha). | At 12 months | |
Primary | Health (Biomarkers of inflammation) | Health indicators from blood spot samples (C-Reactive Protein, Sicam, sVCAM, serum amyloid A, Interleukin-1b, Interleukin-6, Interleukin-8, tumor necrosis factor alpha). | At 18 months | |
Primary | Height | Height of participants | At baseline | |
Primary | Height | Height of participants | At 6 months | |
Primary | Height | Height of participants | At 12 months | |
Primary | Height | Height of participants | At 18 months | |
Primary | Weight | Weight of participants | At baseline | |
Primary | Weight | Weight of participants | At 6 months | |
Primary | Weight | Weight of participants | At 12 months | |
Primary | Weight | Weight of participants | At 18 months | |
Primary | Mid-arm circumference | Measurement of mid-upper arm circumference of participants | At baseline | |
Primary | Mid-arm circumference | Measurement of mid-upper arm circumference of participants | At 6 months | |
Primary | Mid-arm circumference | Measurement of mid-upper arm circumference of participants | At 12 months | |
Primary | Mid-arm circumference | Measurement of mid-upper arm circumference of participants | At 18 months | |
Secondary | Personal exposure to fine particulate matter (PM2.5) | 48 hour integrated personal PM2.5 concentrations from filter measurements | 48 hour deployment periods | |
Secondary | Personal exposure to carbon monoxide (CO) | Daily average and integrated personal CO concentrations | 48 hour deployment periods | |
Secondary | Kitchen area concentrations of carbon monoxide (CO) | Daily average and integrated kitchen area CO concentrations | 48 hour deployment periods | |
Secondary | Kitchen area concentrations of fine particulate matter (PM2.5) | 48 hour integrated kitchen area PM2.5 concentrations from filter measurements | 48 hour deployment periods | |
Secondary | Self-reported stove usage | Surveys administered to respondents (primary cooks) | At baseline | |
Secondary | Self-reported stove usage | Surveys administered to respondents (primary cooks) | At 6 months | |
Secondary | Self-reported stove usage | Surveys administered to respondents (primary cooks) | At 12 months | |
Secondary | Self-reported stove usage | Surveys administered to respondents (primary cooks) | At 18 months | |
Secondary | Stove usage as measured by devices | Continuous stove usage indicators as measured by temperature loggers on stoves | Throughout data collection period, approximately 2 years. |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03995979 -
Inflammation and Protein Restriction
|
N/A | |
Completed |
NCT03255187 -
Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution
|
N/A | |
Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
Completed |
NCT03577223 -
Egg Effects on the Immunomodulatory Properties of HDL
|
N/A | |
Completed |
NCT04383561 -
Relationship Between LRG and Periodontal Disease
|
N/A | |
Active, not recruiting |
NCT03622632 -
Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association
|
||
Completed |
NCT06216015 -
Exercise Training and Kidney Transplantation
|
N/A | |
Completed |
NCT04856748 -
Nomogram to Diagnose Prostatic Inflammation (PIN) in Men With Lower Urinary Tract Symptoms
|
||
Completed |
NCT05529693 -
Efficacy of a Probiotic Strain on Level of Markers of Inflammation in an Elderly Population
|
N/A | |
Recruiting |
NCT05415397 -
Treating Immuno-metabolic Depression With Anti-inflammatory Drugs
|
Phase 3 | |
Recruiting |
NCT05670301 -
Flemish Joint Effort for Biomarker pRofiling in Inflammatory Systemic Diseases
|
N/A | |
Recruiting |
NCT05775731 -
Markers of Inflammation and of the Pro-thrombotic State in Hospital Shift and Day Workers
|
||
Recruiting |
NCT04543877 -
WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study
|
Early Phase 1 | |
Completed |
NCT03859934 -
Metabolic Effects of Melatonin Treatment
|
Phase 1 | |
Completed |
NCT03429920 -
Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors
|
N/A | |
Completed |
NCT06065241 -
Quantifiably Determine if the Botanical Formulation, LLP-01, Has a Significant Clinical Effect on Proteomic Inflammatory Biomarkers and Epigenetic Changes in Healthy, Older Individuals.
|
N/A | |
Completed |
NCT05864352 -
The Role of Dietary Titanium Dioxide on the Human Gut Microbiome and Health
|
||
Completed |
NCT03318731 -
Efficacy and Safety of Fenugreek Extract on Markers of Muscle Damage and Inflammation in Untrained Males
|
N/A | |
Not yet recruiting |
NCT06134076 -
Comparing Effects of Fermented and Unfermented Pulses and Gut Microbiota
|
N/A | |
Not yet recruiting |
NCT06159543 -
The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes
|
N/A |