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PTP1B Implication in the Vascular Dysfunction Associated With Obstructive Sleep Apnea — MacroSAS  

Inflammation Clinical Trial

Official title:
PTP1B Implication in the Vascular Dysfunction Associated With Obstructive Sleep Apnea

Clinical Trial Summary

Obstructive sleep apnea (OSA) syndrome is associated with increased vascular dysfunction and atherosclerosis. Especially, it has been shown that OSA associated intermittent hypoxia represents a pro inflammatory stimulus resulting in macrophage polarization. Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling pathways involved in atherosclerosis. It has been shown that myeloid PTP1B deficiency protects against atherosclerosis. As hypoxia has also been shown to increase PTP1B expression and activity, this study will evaluate the myeloid PTP1B expression and activity in patients with OSA as compared to controls and will investigate myeloid PTP1B involvement in the vascular pro inflammatory precess described in OSA.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04235023
Study type Interventional
Source University Hospital, Angers
Contact
Status Completed
Phase N/A
Start date February 4, 2020
Completion date February 3, 2022
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