Inflammation Clinical Trial
Official title:
Metabolic, Vascular and Cognitive Effects of Treatment With Anthocyanins in Older Adults at Risk for Adverse Outcomes - a Pilot Study
The purpose of this study is to examine weather treatment with anthocyanins will affect lipid
profile, markers of inflammation and oxidative stress in addition to antioxidative level in
serum to the better in persons with increased risk of dementia.
The purpose of this study is to examine weather treatment with anthocyanins will increase the
score of relevant tests of cognitive function.
The investigators will do an open pilot study where patients receive anthocyanin for 16
weeks. 34 patients are expected to be included.
In addition we will include 20 healthy Controls.
Design, method and material:
The investigators will first do an open pilot study where 30 people will receive anthocyanins
for 16 weeks.
The investigators aim to recruit persons with increased risk of cognitive reduction: persons
over 50 years with stable coronary heart disease (CAD) from the cardiology department
Stavanger University Hospital. In addition will persons with mild cognitive impairment or
mild dementia be included from the memory outpatient clinic, Stavanger University Hospital.
Blood will be taken by venepuncture by an experienced nurse, centrifuged and handled in
according to standardized procedures.
The patients will be tested in relevant tests of cognitive function at inclusion and after 16
weeks. At inclusion the patients will be tested in Mini Mental State Examination (MMSE) and
Geriatric depression scale (GDS) to make sure that the patients meet the inclusion criteria.
At inclusion and after 16 weeks the patients will be tested in Word List Memory Word List
Recall Word List Recognition, Trail Making Test A + B and Stroop Word and Colour test.
From the healthy controls blood will be taken at inclusion and study end.
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