Inflammation Clinical Trial
Official title:
Randomized Clinical Trial Evaluating Anti-inflammatory Effect of Low Molecular-Weight Heparin in Pediatric Cataract and Intraocular Lens Surgery
The purpose of this study is to determine if intraocular infusion of low-molecular weight heparin (enoxaparin) influences postoperative inflammation following pediatric cataract surgery with intraocular lens (IOL) implantation.
Despite advances in cataract surgery in children, postoperative inflammation is a
significant complication following pediatric cataract surgery. Any drug that prevents or
decreases this inflammation would be beneficial.
Heparin has anti-inflammatory and antiproliferative effects as well as anticoagulant
properties. Several studies on animal and adult human eyes show that adding heparin to the
irrigating solution during cataract surgery results in less disturbance of the blood-aqueous
barrier and helps prevent posterior capsule opacification (PCO).
A prospective, randomized, controlled and masked study is mandatory to evaluate the
anti-inflammatory effect of Low-molecular weight Heparin for pediatric cataract surgery
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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