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Infertility clinical trials

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NCT ID: NCT02048527 Completed - Infertility Clinical Trials

Single-step Versus Sequential Media in Preimplantation Embryo Development and Pregnancy Rates

Start date: January 2014
Phase: N/A
Study type: Interventional

Sequential culture media were introduced in order to meet the changing requirements of the developing embryo in vitro. However, there has been renewed interest in the use of single-step media, which allow the embryo itself to choose the necessary nutrients while maintaining a more stable culture environment. Previous studies suggest that sequential media do not appear superior to single-step media.

NCT ID: NCT02047227 Completed - Infertility Clinical Trials

Phase 3 Study to Evaluate the Efficacy and Safety of Pergoveris® in Assisted Reproductive Technology (ESPART)

ESPART
Start date: January 2014
Phase: Phase 3
Study type: Interventional

This is a Phase 3, randomized, controlled, single-blind, multicenter, parallel-arm trial to assess the safety and efficacy of Pergoveris® (recombinant human follicle stimulating hormone [r-hFSH]/recombinant human luteinising hormone [r-hLH]) and GONAL-f® for multifollicular development as part of an assisted reproductive technology (ART) treatment cycle in poor ovarian responders, as aligned with the 2011 Consensus Meeting of the European Society of Human Reproduction and Embryology (ESHRE) criteria.

NCT ID: NCT02040545 Completed - Infertility Clinical Trials

Salivary Diagnostic Testing for IVF

Start date: May 21, 2010
Phase: N/A
Study type: Observational

This study aims to determine the performance of a salivary hormone competitive immunoassay for monitoring patients during treatment for infertility.

NCT ID: NCT02032264 Completed - Infertility Clinical Trials

Next Generation Sequencing Screening for Embryonic Ploidy Status

nexgen
Start date: December 2013
Phase: N/A
Study type: Interventional

To evaluate the benefits of using next generation sequencing to assess embryonic aneuploidy. All viable blastocysts will be biopsied and cryopreserved for future transfer. After the final embryo is cryopreserved, patients will be randomized to either the intervention group or the control group. Patients and doctors are blinded to the randomization until study completion. A Double Embryo Transfer (DET) will be performed with either screened or unscreened embryos depending on randomization. A Single Embryo Transfer (SET) may occur in cases where only one embryo is available for transfer.

NCT ID: NCT02032251 Completed - Infertility Clinical Trials

Reduction of Sperm DNA Fragmentation by Oral Ginger

Start date: December 2009
Phase: Phase 2
Study type: Interventional

This study is a randomized, double blind, controlled clinical trials assess the efficacy of the ginger oral treatment on sperm DNA fragmentation, sperm parameters and male hormones.

NCT ID: NCT02031549 Completed - Infertility Clinical Trials

Prospective Observational Correlation of Sperm Assay Results With Blastocyst Formation

Start date: January 2014
Phase: N/A
Study type: Observational

We will investigate potential correlation between SpermComet DNA fragmentation assay results and IVF cycle outcome.

NCT ID: NCT02026661 Completed - Infertility Clinical Trials

Effectiveness of Intracytoplasmic Sperm Injection and Laser Assisted Hatching on in Vitro Fertilization Outcomes of Patients With Different Causes of Infertility

Start date: January 2014
Phase: N/A
Study type: Observational

To determine the association of factors affecting the clinical pregnancy and live birth rates in patients undergoing in vitro fertilization (IVF) who received intracytoplasmic sperm injection (ICSI) and/or laser assisted hatching (LAH) or neither. After applying the inclusion and exclusion criteria, a total of 400 women who underwent IVF between January 2007 and December 2010 were included in the analysis. Patients were divided into 4 groups; 1) those that did not receive ICSI or LAH, 2) those that received ICSI only, 3) those that received LAH only, and 4) those that received both ICSI and LAH. Univariate and multivariate analyses were performed.

NCT ID: NCT02026193 Completed - Infertility Clinical Trials

IVF Hyper-responders: Oocyte Vitrification Compared With Embryo Freezing

Start date: January 2014
Phase: N/A
Study type: Interventional

The chances to achieve pregnancy after retrieving >15 oocytes are not good, probably because of bad effect on the endometrium (uterine inner lining). Therefore, in most such cases the investigators prefer to freeze all embryos, and transfer in a thaw cycle. With the introduction of oocyte vitrification (very fast cooling) technology, a new option emerged: to freeze un-fertilized eggs, to be fertilized and used later in a thaw cycle. The purpose of this study is to compare the outcome of these two approaches.

NCT ID: NCT02025270 Completed - Male Infertility Clinical Trials

MSCs For Treatment of Azoospermic Patients

Start date: October 15, 2012
Phase: Phase 1/Phase 2
Study type: Interventional

In this study, we performed autologous BMDMSC transplantation to the testis of Azoospermic patients in a trial to enhance and activate the spermatogonial stem cells of the testis and aiming to produce motile sperm.

NCT ID: NCT02018159 Completed - Infertility Clinical Trials

An Explorative Prospective Observational Study to Describe Morphokinetic De-selection Parameters in Human Embryos

Start date: January 2014
Phase: N/A
Study type: Observational

This post-marketing, multi-center prospective study will be conducted in a open-label, non-interventional setting, for women seeking fertility treatment and will describe morphokinetic de-selection parameters in human embryos.