Infertility Unexplained Clinical Trial
Official title:
Modulation of the Reproductive Microbiota as a Strategy to Increase Rates of Reproductive Success in Couples With Infertility of Unknown Origin
Verified date | May 2023 |
Source | Universidad Complutense de Madrid |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The objective of the project is to elucidate if the oral administration of Ligilactobacillus salivarius CECT5713 is capable of improving the rates of term pregnancies in couples with infertility problems of unknown cause. On the other hand, the project is aimed to detect microbiological, immunological and hormonal markers that allow the identification of couples in which the administration of the strain could be particularly effective. This is a randomized, double-blind, parallel-group controlled nutritional intervention study. The intervention (Ligilactobacillus salivarius CECT5713 or placebo) will be performed during the 6 months prior to the fertility treatment and during the first IVF cycle (estimated 1-2 months). In case of pregnancy, the woman will continue the treatment until 12 weeks of gestation.
Status | Active, not recruiting |
Enrollment | 70 |
Est. completion date | December 29, 2023 |
Est. primary completion date | May 3, 2023 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 45 Years |
Eligibility | Inclusion Criteria: - legal age - Intention to achieve a pregnancy, but without achieving it; - Be willing to undergo in vitro fertilization treatment; - Be on the waiting list for the IVF cycle with an expected waiting time > 5 months. Exclusion Criteria: - Sterility in one of the members of the couple (azoospermia; impermeability of the fallopian tubes...). - Genitourinary malformations; - Concurrence of other severe diseases (e.g.: cancer, AIDS, ALS, morbid obesity...) or uncontrolled diseases (inflammatory bowel diseases, diabetes...). - Treatment/intervention other than the planned IVF after the start date of the intervention. - Antibiotic treatment at the start date of the intervention. - Intention to consume another probiotic supplement in the following 3 months. - Participation in another clinical trial. - Allergic/intolerant to the excipient. - Inability to understand the informed consent form and/or to follow the basic instructions of the trial. |
Country | Name | City | State |
---|---|---|---|
Spain | Dpt. Nutrición y Ciencia de los Alimentos | Madrid |
Lead Sponsor | Collaborator |
---|---|
Universidad Complutense de Madrid | Biosearch S.A., Hospital San Carlos, Madrid |
Spain,
Fernandez L, Castro I, Arroyo R, Alba C, Beltran D, Rodriguez JM. Application of Ligilactobacillus salivarius CECT5713 to Achieve Term Pregnancies in Women with Repetitive Abortion or Infertility of Unknown Origin by Microbiological and Immunological Modulation of the Vaginal Ecosystem. Nutrients. 2021 Jan 6;13(1):162. doi: 10.3390/nu13010162. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Successful pregnancies | Total number of pregnancies with delivery of a healthy baby | 9 months | |
Secondary | Modification of the vaginal microbiota | Variation in the concentration of lactobacilli and other microbes in vaginal samples | 9 months | |
Secondary | Vaginal immunomodulation | Variation in the concentration of immune factors in vaginal samples | 9 months |
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