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Infertility Unexplained clinical trials

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NCT ID: NCT06290518 Completed - Clinical trials for Infertility Unexplained

Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

The objective of the project is to elucidate if the oral administration of Ligilactobacillus salivarius CECT5713 is capable of improving the rates of term pregnancies in couples with infertility problems of unknown cause. On the other hand, the project is aimed to detect microbiological, immunological and hormonal markers that allow the identification of couples in which the administration of the strain could be particularly effective. This is a randomized, double-blind, parallel-group controlled nutritional intervention study. The intervention (Ligilactobacillus salivarius CECT5713 or placebo) will be performed during the 6 months prior to the fertility treatment and during the first IVF cycle (estimated 1-2 months). In case of pregnancy, the woman will continue the treatment until 12 weeks of gestation.

NCT ID: NCT06174298 Recruiting - Infertility Clinical Trials

The Role of Granulocyte Colony Stimulating Factor in Embryo Transfer Outcomes

Start date: March 20, 2024
Phase: Phase 4
Study type: Interventional

The goal of this clinical trial is to test the effect of granulocyte colony-stimulating factor (G-CSF, A.K.A. Filgrastim) in infertility patients undergoing in vitro fertilization (IVF) treatment. The main question it aims to answer is: Can in vitro fertilization-embryo transfer (IVF-ET) outcomes be improved by supplementing the transfer media with Granulocyte colony-stimulating factor (GCSF)? Participants will undergo their embryo transfer as per the normal clinic protocol but will be randomized to either receive the standard embryo transfer media or the GCSG-supplemented transfer media. Researchers will compare the GCSF and standard transfer media groups to see if clinical outcomes are improved (i.e., implantation rate, pregnancy, clinical pregnancy rate, live birth rate).

NCT ID: NCT05946655 Completed - Clinical trials for Infertility Unexplained

Diagnostics of Chronic Endometritis in Infertility

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

Chronic endometritis (CE) is characterized by the presence of atypical plasma cell infiltrates (CD138 positive) in the endometrial stroma. Recent analyzes suggest that CE adversely affects fertility by reducing endometrial receptivity, impairing decidualization and uterine contractility, thus increasing the risk of recurrent pregnancy loss and implantation failure. It is likely that a significant proportion of idiopathic infertility cases are due to CE. The diagnosis of CE is a challenge because the clinical examination and transvaginal ultrasonography are considered non-specific. The recent scientific research has been aimed at identifying hysteroscopic CE diagnostic criteria and establishing the compatibility of ultrasonographic, hysteroscopic, histopathological (including the use of immunohistochemical testing with antibodies against human CD138) and microbiological diagnoses. Preliminary literature results suggested that successful treatment of CE with antibiotics could improve live birth rates.

NCT ID: NCT05896657 Active, not recruiting - Clinical trials for Infertility Unexplained

Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

The objective of the project is to elucidate if the oral administration of Ligilactobacillus salivarius CECT5713 is capable of improving the rates of term pregnancies in couples with infertility problems of unknown cause. On the other hand, the project is aimed to detect microbiological, immunological and hormonal markers that allow the identification of couples in which the administration of the strain could be particularly effective. This is a randomized, double-blind, parallel-group controlled nutritional intervention study. The intervention (Ligilactobacillus salivarius CECT5713 or placebo) will be performed during the 6 months prior to the fertility treatment and during the first IVF cycle (estimated 1-2 months). In case of pregnancy, the woman will continue the treatment until 12 weeks of gestation.

NCT ID: NCT05824819 Recruiting - Endometriosis Clinical Trials

Endometriosis and Peritoneal Dysbiosis

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

Endometriosis is a complex clinical syndrome that impairs many aspects of a woman's life, characterized by a chronic estrogen-dependent inflammatory process, mainly affecting the pelvic organs, with ectopic presence of tissue analogous to the uterine mucosa (endometrium). Despite intensive research in the field of etiopathogenesis, its cause has not yet been determined, and treatment remains symptomatic. Endometriosis causes two main complications, i.e. pelvic pain syndrome and infertility. In recent years, thanks to the analysis of the human microbiome, it has become possible to deepen the knowledge of the physiological and pathological interactions between microorganisms inhabiting various body areas and the host. Bacteria may enter the peritoneal cavity in the mechanism of retrograde menstruation and translocate from the intestines, and then promote the development of local and systemic inflammation, leading to the symptoms of endometriosis. The study is to determine whether the presence of a specific intestinal, peritoneal and uterine microbiome correlates with endometriosis stage and whether its presence predisposes to increased pain or infertility. Concordance or divergence of bacterial populations inhabiting the peritoneal and uterine cavities could have clinical implications, i.e. the possibility of empirical antibiotic therapy in patients undergoing only endometrial aspiration biopsy and not opting for surgical treatment.

NCT ID: NCT05789407 Completed - Endometriosis Clinical Trials

Organic Pollutants in Pelvic Endometriosis

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

The health toxicity of polycyclic aromatic hydrocarbons (PAHs), present in air and food, generated during energy production and waste incineration, is well known. PAHs can activate the aryl hydrocarbon receptor, which may interact with classic estrogen receptors and modify estrogen-dependent inflammation in endometriosis. There is no data on the hypothetical role of PAHs in the etiopathogenesis of endometriosis. The aim was to compare PAHs concentrations in visceral fat in women with endometriosis and idiopathic infertility.

NCT ID: NCT05693220 Recruiting - Infertility Clinical Trials

Sperm Preparation Prior to Intrauterine Insemination Study

PIoUS
Start date: February 5, 2023
Phase: N/A
Study type: Interventional

This is a randomized controlled trial comparing density gradient centrifugation and microfluidic sperm sorting in patients undergoing intrauterine insemination to evaluate cumulative pregnancy outcomes.

NCT ID: NCT05680350 Completed - Endometriosis Clinical Trials

Relation Between MicroRNA 203 and 210 and Sparing the Laparoscopic Examination in Cases of Unexplained Infertility

Start date: November 7, 2020
Phase: N/A
Study type: Interventional

The study targets to evaluate the role of estimation of plasma expression levels of gene of microRNAs 203 and 210 in helping to diagnose and grade endometriosis. The study included women with unexplained infertility and clinical picture suggestive of presence of endometriosis were divided randomly into two groups: Control and study groups. All patients underwent exploratory laparotomy for diagnosis and grading of endometriosis if present. Patients of study group gave blood samples for estimation of plasma expression levels of microRNA 203 and 210 using qRT-PCR procedure.

NCT ID: NCT05670795 Recruiting - Clinical trials for Infertility Unexplained

Comparison of Recombinant Follicle Stimulating Hormone and the Combination of Recombinant Follicle Stimulating Hormone With Clomiphene Citrate in Stimulated Intrauterine Insemination Cycles

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

The aim of study is to evaluate the results of two different protocols for ovulation induction during IUI cycles. All patients undergo IUI cycles are randomly divided in to two groups. the first group is recombinant follicle stimulating hormone and the second group is the combination of recombinant follicle stimulating hormone with clomiphene citrate.

NCT ID: NCT05599724 Recruiting - Infertility Clinical Trials

PMA-FERTITHEQUE Biocollection

FERTITHEQUE
Start date: November 11, 2022
Phase:
Study type: Observational [Patient Registry]

Creation of a patient library in Medically Assisted Procreation to allow the implementation of further research with the following objectives: - To identify new relevant biomarkers in patients who will carry a pregnancy to term - To better specify or identify new infertility risk factors - To identify new relevant biomarkers in patients with reduced ovarian reserve Four consultations are planned with biological et clinical collection.