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Infection clinical trials

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NCT ID: NCT03222804 Withdrawn - Clinical trials for Microbial Colonization

Milk Oriented Microbiota

MOM
Start date: May 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if supplementing healthy term infants delivered vaginally who consume breast milk, formula, or both with a probiotic for 21 consecutive days increases levels of bacteria in infants' stool.

NCT ID: NCT03196921 Withdrawn - Clinical trials for Cryptococcal Infections

Efficacy and Safety of Oral Encochleated Amphotericin B for the Treatment of Cryptococcal Infection

ORACLE
Start date: October 1, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This will be an open label phase I/II prospective cohort study to determine the efficacy and safety of CAMB for the treatment and prevention of cryptococcal infection.

NCT ID: NCT03167957 Withdrawn - Clinical trials for Candidiasis, Vulvovaginal

Efficacy and Safety of Oral Encochleated Amphotericin B (CAMB) in the Treatment of Fluconazole-Resistant Vulvovaginal Candidiasis

Start date: December 2019
Phase: Phase 2
Study type: Interventional

This is a single-center, open-label, pilot study to evaluate the efficacy of 14 days of CAMB dosing in subjects with fluconazole-resistant vulvovaginal candidiasis (VVC).

NCT ID: NCT03024177 Withdrawn - Clinical trials for Upper Respiratory Tract Infection

A Study of Vapendavir Treatment of Hematopoietic Stem Cell Transplant Subjects With Symptomatic Rhinovirus Infection

Start date: n/a
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, placebo-controlled study of vapendavir treatment of laboratory-confirmed and symptomatic HRV infection of the upper respiratory tract in allogeneic and autologous stem cell transplant subjects. The aim of this study is to evaluate the effect of vapendavir on laboratory-confirmed HRV upper-respiratory tract infection in HSCT patients, as measured by viral load changes, worsening of upper respiratory tract infection (URTI) to lower respiratory tract infection (LRTI), duration of clinical symptoms, the occurrence of supplemental oxygen use, duration of viral shedding, hospital admission and duration of hospitalization, incidence of secondary bacterial infection, and mortality rates. Additionally, the safety and tolerability of vapendavir, and the vapendavir plasma levels achieved in the HSCT population, and the profile of viral resistance development will also be assessed.

NCT ID: NCT02981550 Withdrawn - Clinical trials for Respiratory Infection

Infection Detection by Breath Analysis

Start date: November 2016
Phase: N/A
Study type: Observational

The purpose of this feasibility study is to test a device which analyzes breath and may allow doctors and health professionals to immediately determine if an ill patient has a specific type of bacterial infection. This will allow a health professional to provide immediate targeted antibiotics to properly start treatment without delay.

NCT ID: NCT02904434 Withdrawn - Infection Clinical Trials

Gastrointestinal Implications of Voriconazole Exposure

GIVE
Start date: September 2016
Phase:
Study type: Observational

Voriconazole has better response rates, improved survival and less adverse side effects compared to other drugs for the treatment of invasive fungal infections making it a desirable therapeutic option for children. However, dosing is unpredictable in children and this leads to therapeutic failure. This study aims to understand the physiological differences between children and adults that leads to therapeutic failure of voriconazole in children.

NCT ID: NCT02899702 Withdrawn - Clinical trials for Staphylococcal Infection

Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children

IGHN2
Start date: September 2020
Phase: Phase 4
Study type: Interventional

IGHN2 is an international, multicenter, double blind, randomized controlled trial aimed at assessing the efficacy on organ dysfunctions of Intravenous Immunoglobulins (IVIG) treatment in the acute phase of streptococcal or staphylococcal toxic shock syndrome in children.

NCT ID: NCT02764528 Withdrawn - Infection Clinical Trials

Intervention Study to Improve Maternal Handwashing

Start date: February 1, 2016
Phase: N/A
Study type: Interventional

The purpose of the handwashing intervention trial is to determine whether an interactive, storytelling approach to promoting handwashing with soap by health care workers can improve mothers' handwashing behavior during the first month of her child's life.

NCT ID: NCT02730364 Withdrawn - Clinical trials for Infections, Respiratory Tract

An Efficacy and Safety Study of Theraflu Night Powder as Oral Solution for Cold and Flu

Start date: February 1, 2017
Phase: Phase 3
Study type: Interventional

The purpose of the study is to assess the short term efficacy of the Theraflu Night powder for oral solution in the Russian population in "Short term relief of the symptoms of colds, chills and influenza, including mild to moderate pain, fever and nasal congestion".

NCT ID: NCT02702427 Withdrawn - Clinical trials for Cytomegalovirus Infection

Virus-specific ImmunoTherapy Following Allogeneic Stem Cell Transplantation

VISIT
Start date: August 3, 2016
Phase: Phase 1/Phase 2
Study type: Interventional

Invasive infections with CMV and Adenovirus, not responding to virostatic treatment are treated with virusspecific donor derived or autologous virusspecific T-cells.