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Individuality clinical trials

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NCT ID: NCT05201534 Recruiting - Child Development Clinical Trials

Interventions in Mathematics and Cognitive Skills

Start date: May 5, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning disabilities (MLD).

NCT ID: NCT04601792 Recruiting - Quality of Life Clinical Trials

A Series of N-of-1 Trials of Traditional Chinese Medicine Based on Bayesian Method

Start date: December 1, 2019
Phase: Phase 4
Study type: Interventional

The guiding role of parallel randomized controlled trials in clinical practice is limited due to the insufficiency of individual information. Our previous studies showed that Single case randomized controlled trials (referred to as N-of-1 trials) could reflect the individualized characteristics of traditional Chinese medicine (TCM) syndrome differentiation with good feasibility, but the sensitivity was low. This study aims to compare the efficacy of treatment based on syndrome differentiation with controlled decoctions (placebo, and the method of strengthening the body resistance and removing phlegm) among patients with stable bronchiectasis through a series of N-of-1 trials (single-patient, double-blind, randomized, multiple crossover design), with the 7 point-likert scale of the most concerned symptoms as the main outcome. Hierarchical Bayesian statistical methods and some parameters and variables will be introduced, such as TCM syndrome type, potential residue effect of TCM, etc. The sensitivity and applicability of various mathematical models (Hierarchical Bayesian, paired t-test and Meta-analysis) for N-of-1 trials of TCM will be tested, for the purpose of improving the sensitivity and applicability of N-of-1 trials of TCM both on individual and group levels.

NCT ID: NCT03905993 Completed - Healthy Subjects Clinical Trials

Milieu Intérieur Collection - Genetic & Environmental Determinants Of Immune Phenotype Variance

MI
Start date: September 17, 2012
Phase:
Study type: Observational

The purpose of this study is to assess the determinants of immunologic variance within the general healthy population.

NCT ID: NCT03147443 Recruiting - Quality of Life Clinical Trials

Evaluating the Effects of Traditional Chinese Medicine by N-of-1 Trials

Start date: March 1, 2017
Phase: Phase 4
Study type: Interventional

Treatment based on syndrome differentiation is the essence of traditional Chinese Medicine(TCM) and forms the individualized treatment. N-of-1 trials may be a good clinical effect evaluation method for the individualized treatment of TCM. This study aims to compare: (1) the efficacy of syndrome differentiation(individualized decoction) with placebo, (2)the efficacy of syndrome differentiation(individualized decoction) with the same prescription minus heat-clearing Chinese herbs, for patients with stable bronchiectasis through N-of-1 trials.

NCT ID: NCT02906306 Completed - Well-being Clinical Trials

Effects of Individual and Group Occupational Therapy on General Self-Efficacy, Psychological Well-Being, Personal Independence and Occupational Therapy in Older Adults

Start date: September 2014
Phase: N/A
Study type: Interventional

The objective of this study is to determine whether individual and/or group occupational therapy leads to changes in generalized self-efficacy and psychological well-being, and to identify the type of therapy that has the best effects on older adults.

NCT ID: NCT02768636 Completed - Individuality Clinical Trials

Can Omega-3 Improve Heart Rate Variability Measurement?

HRV
Start date: April 2016
Phase: Phase 4
Study type: Interventional

Heart rate variability can represent physiological and psychological levels via sympathetic and parasympathetic variables on autonomic nervous function. Omega-3 has shown that it can effect on physiological and psychological with many good results. The pathways to explain about its effect had been studied in many contexts. Effect to autonomic nervous function by Omega-3 is our interesting question.

NCT ID: NCT02761031 Completed - Clinical trials for Perioperative/Postoperative Complications

Perioperative Heart Rate Variability Analysis in Realtime

PHERVR
Start date: April 2016
Phase:
Study type: Observational

This study will record patient electrocardiograms - as well as various other body signals (e.g., blood pressure, pulse wave, peripheral hemoglobin oxygen saturation) - as monitored routinely both during and immediately subsequent to surgical operations performed under general anesthesia. Through retrospective analysis of patients' heart rate variability (HRV), in concert with the other abovementioned parameters, the investigators seek to forward the development of novel mathematical models and tools for on-line detection of cardiovascular and autonomic dysfunction in the perioperative setting.

NCT ID: NCT02654704 Terminated - Healthy Clinical Trials

Vaccination Responses in Young and Older Adults

Start date: November 2015
Phase:
Study type: Observational

To follow longitudinally healthy and immune-compromised responses to pneumococcal vaccination, in 60+ individuals towards the development of personalized medicine implementation (minimum enrollments in 2 age categories: young adults[18-25], older adults [55+], within each category: 10+ healthy, 10+ asthma, 10+ immune-compromised [e.g. leukemia or autoimmune disorders]). The approach will profile thousands of molecular components utilizing high-throughput technologies and integrate these data to obtain personalized immune response to vaccination. The study will provide insights into immune response mechanisms specific to asthmatics, immune compromised and healthy individuals, as well as in response to vaccination. Additionally the differences in dynamic response across the two age groups will be investigated.

NCT ID: NCT02478034 Completed - Individuality Clinical Trials

Effects of Mineralocorticoid Receptor Stimulation on Cognition

MR-STIM
Start date: May 2015
Phase: N/A
Study type: Interventional

In this study the effects of mineralocorticoid stimulation on social cognition will be investigated in healthy young individuals.

NCT ID: NCT02478021 Completed - Individuality Clinical Trials

Effects of Hydrocortisone on Social Cognition and Memory

CORT-COG
Start date: September 2014
Phase: N/A
Study type: Interventional

The effects of hydrocortisone on cognition will be investigated.