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Role of the Fibroblast Activation Protein (FAP) as Biomarker of Fibrotic Lung Diseases — FAPIPET  

Idiopathic Pulmonary Fibrosis Clinical Trial

Official title:
Role of the Fibroblast Activation Protein (FAP) as Biomarker of Fibrotic Lung Diseases

Clinical Trial Summary

To evaluate the effect of an anti-fibrotic treatment initiation on the fibrotic activity as assessed by FAPI PET/CT.

Clinical Trial Description

To evaluate the use of the fibroblast activation protein (FAP) as a biomarker of fibrotic lung disease (idiopathic pulmonary fibrosis (IPF) and non-IPF ILDs). The study will include both analysis of FAP expression in samples stored in the biobank of the department of Pneumology (BAL, blood, induced sputum and EBC) (cohort A) and lung FAPI uptake on PET/CT scans performed at the department of Nuclear Medicine: - before and after the initiation of an antifibrotic therapy (IPF or PPF) (cohort B) - before and after the initiation of corticosteroid therapy in case of an acute exacerbation of ILD (cohort C) - before and after the initiation of an immunosuppressive drug in the context of non-IPF pulmonary fibrosis (cohort D). - before lung transplantation, surgery or biopsy to correlate with FAP expression determined by immunohistochemical analysis (IHC) (cohort E). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06189820
Study type Interventional
Source Erasme University Hospital
Contact Benjamin Bondue
Phone + 32 (2) 555 5758
Email benjamin.bondue@hubruxelles.be
Status Recruiting
Phase Phase 2
Start date March 9, 2023
Completion date March 9, 2027
View Details
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