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GKT137831 in IPF Patients With Idiopathic Pulmonary Fibrosis — GKT137831  

Idiopathic Pulmonary Fibrosis Clinical Trial

Official title:
A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Trial of GKT137831 in Patients With Idiopathic Pulmonary Fibrosis

Clinical Trial Summary

A placebo-controlled, multicenter, randomized trial to test GKT137831 in ambulatory patients with idiopathic pulmonary fibrosis. This drug is an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) isoforms. The investigators hypothesize the drug will decrease pulmonary injury due to reactive oxygen species (ROS) generated by NOX enzymes, which are believed to play an important role in the development of IPF. Treatment with GKT137831 could result in significant benefit for a lung disease that has, until now, been almost invariably inexorable. This clinical trial represents the bedside application of a series of NOX translational and basic studies and discoveries, over several years, from the laboratory of Dr. Victor Thannickal.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03865927
Study type Interventional
Source University of Alabama at Birmingham
Contact Steven R Duncan, MD
Phone 205-934-5018
Email srduncan@uabmc.edu
Status Recruiting
Phase Phase 2
Start date September 7, 2020
Completion date January 1, 2025
View Details
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