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Hypoxia clinical trials

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NCT ID: NCT06158295 Recruiting - Pain Clinical Trials

Effects of Walking Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function

Start date: December 1, 2023
Phase: Phase 3
Study type: Interventional

The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention.

NCT ID: NCT06158282 Recruiting - Pain Clinical Trials

Effects of Walking Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function

Start date: December 1, 2023
Phase: Phase 3
Study type: Interventional

The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention.

NCT ID: NCT06158256 Recruiting - Pain Clinical Trials

Effects of Static Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function

Start date: December 1, 2023
Phase: Phase 3
Study type: Interventional

The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent static apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention

NCT ID: NCT06150677 Recruiting - Pain Clinical Trials

Effects of Static Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function

Start date: December 1, 2023
Phase: Phase 3
Study type: Interventional

The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent static apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention.

NCT ID: NCT06142019 Recruiting - Hypoxia Clinical Trials

Pulse Oximeter Accuracy in Healthy Humans During Hypoxia

Start date: March 1, 2024
Phase:
Study type: Observational

The aim of this project is to test the accuracy of pulse oximeters during mild, moderate and severe hypoxia. This is done by comparing the reading of the pulse oximeter during brief, steady state hypoxia with a gold-standard measurement of blood oxygen. This study will be done on healthy male or females between the age group of 18-50.

NCT ID: NCT06140056 Recruiting - Clinical trials for Ventilators, Mechanical

Two Modes of Mechanical Ventilation for Intensive Care Patients With Low Blood Oxygen Due to Breathing Difficulties

Start date: December 8, 2023
Phase: N/A
Study type: Interventional

The study examines individuals admitted to the intensive care unit due to breathing difficulties resulting in not getting enough oxygen into their bodies. These patient will receive mechanical ventilation and this study aims to determine how the pressure inside the lungs changes when using two different modes of mechanical ventilation. The goal is to improve management and care of breathing difficulties by gaining insight into changes in lung pressure during mechanical ventilation, as well as comparing the effectiveness of the two ventilator modes.

NCT ID: NCT06139081 Recruiting - Hypoxemia Clinical Trials

Oxygen Delivery Methods of Nasal Catheter on the Incidence of Hypoxemia in Patients With Painless Gastroscopy

Start date: September 22, 2023
Phase: N/A
Study type: Interventional

In this study, patients undergoing painless gastroscopy were selected to change the nasal catheter oxygen delivery mode to oral oxygen delivery after endoscope implantation, in order to explore the effect of this oxygen delivery mode on the incidence of hypoxemia during general anesthesia gastroscopy.

NCT ID: NCT06128941 Recruiting - Hypoventilation Clinical Trials

Influence of Hypoxic, Normobaric and Hypobaric Training on the Immunometabolism of Post-covid-19 Athletes

Start date: January 3, 2024
Phase: N/A
Study type: Interventional

COVID-19 has significantly impacted sports globally, with event postponements, training disruptions, and wide-ranging concerns. SARS-CoV-2 infection can result in hyperinflammation and cardiopulmonary changes, with hypoxia as an aggravating sign. Hypoxia triggers complex immunometabolic mechanisms, including activation of HIF-1α and induction of HLA-G expression. Hypoxia training protocols benefit aerobic capacity and sports performance, with potential immunological impact. Studying immunometabolic markers in this context can improve athletic preparation and athletes' general health.

NCT ID: NCT06115421 Recruiting - Clinical trials for Anemia in Dialysis-dependent CKD Patients

Effect of Low Doses of Hypoxia-inducible Factor- Prolyl Hydroxylase Enzyme Inhibitor Plus Iron in the Treatment of Anemia in Dialysis-dependent Chronic Kidney Disease Patients

Start date: May 24, 2023
Phase: Phase 4
Study type: Interventional

this study aims to : 1. To compare the efficacy of combining low doses of Roxadustat Hypoxia-Inducible Factor (HIF)-Prolyl Hydroxylase (PHD) inhibitor and iron versus standard treatment with erythropoietin-stimulating agents (ESA) in the treatment of anemia as a complication of chronic kidney disease (CKD) among dialysis-dependent patients. 2. To emphasize the safety profile of low doses of Roxadustat HIF-PHD. 3. To assess changes in the quality of life of patients with kidney disease before and after treatment.

NCT ID: NCT06087614 Recruiting - Clinical trials for Head and Neck Squamous Cell Carcinoma

Dose Escalation Using Hypoxia-adjusted Radiotherapy

DE-HyART
Start date: April 8, 2024
Phase: Phase 2
Study type: Interventional

DE-HyART is a phase II clinical trial aimed at understanding the effects of escalating radiation doses to hypoxic sub-volumes inherent to squamous cell head and neck cancer. The study is aimed at assessing locoregional control, feasibility, and acceptable toxicity with such a strategy.