Effects of Physical Training in Altered Environmental Conditions on Exercise Performance

Hypoxia, Altitude Clinical Trial

Official title:

Effects of Physical Training in Altered Environmental Conditions (in a Hypoxic Thermoclimatic Chamber) on Exercise Capacity and Selected Physiological Responses of the Human Body

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06159374
• Other study ID #: MEIN 2021/DPI/229
• Status: Recruiting
• Phase: N/A
• Start date: January 1, 2022
• Est. completion date: December 31, 2025

Study information

• Verified date: December 2023
• Source: University School of Physical Education, Krakow, Poland
• Contact: Anna Radon, MSc
• Phone: +45126831142
• Email: anna.radon[@]awf.krakow.pl
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The main objective of the study is to evaluate the physiological-biochemical effects of physical training under artificially altered climatic conditions (using a hypoxic thermoclimatic chamber) in particular to determine the effect of such training on exercise capacity and physiological response, including the effect of training in high-performance athletes. The study will evaluate the effects of physical training and the simultaneous application of hypoxia and heat/cold on aerobic and anaerobic capacity and the physiological response of the human body. The aim of the study is to find the most favourable environmental conditions for physical training in order to maximise physical performance.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 128
• Est. completion date: December 31, 2025
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

absence of medical contraindications to high-intensity physical exertion. The medical examination is required (included an exercise ECG, blood tests to exclude anemia or low hemoglobin and iron concentration) Exclusion Criteria: any training (including hypoxia training or exposure) performed in the 6 months prior to the beginning of the intervention

Related Conditions & MeSH terms

• Altitude Sickness
• Cold Exposure
• Heat Exposure
• Hypoxia
• Hypoxia, Altitude

Intervention

Other:
• exercise and environmental conditions
Participants will perform interval training for 4 weeks in a variety of environmental conditions. There will be a measurement of aerobic and anaerobic capacity before and after the training. Before and after the first and last workout, blood will be drawn for biochemical analysis.

Locations

Country	Name	City	State
Poland	University School of Physical Education in Cracow	Kraków

Sponsors (1)

Lead Sponsor	Collaborator
University School of Physical Education, Krakow, Poland

Country where clinical trial is conducted

Poland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measurement of aerobic capacity (endurance)	Measurement of maximal oxygen uptake and determination of ventilatory thresholds (ergospirometry)	7 days before training and 7-10 days after the training. Training will last 4 weeks.
Primary	Measurement of anaerobic capacity	Measurement of maximal anaerobic power (Wingate Anaerobic Test)	7 days before training and 7-10 days after the training. Training will last 4 weeks.
Primary	Blood analysis	indicators of muscle damage, inflammatory markers (interleukins), oxidative stress, lactate concentration, tissue oxygenation, selected hormones (including erythropoietin) and enzymes, HIF (hypoxia inducible factor), selected vitamins, morphology (including reticulocytes), rheology and blood biochemistry	Before (10 min) and after (3 min) the first and last training. The training will last 4 weeks and will consist of 12 workouts