Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia

Status Completed

Clinical Trial Summary

Clinical Trial Description

This study seeks to determine whether a simple, single intervention of Cetirizine / Zyrtec® use can improve exercise performance of active individuals when acutely exposed to altitude. For this project, healthy subjects will perform steady state and progressive work rate exercise, endurance performance time trials, and repeated sprint performance time trials in the laboratory at a simulated altitude of 3000m (9900ft) after dosing with 10 mg of Cetirizine or a placebo in a repeated measures design. Non-invasive techniques (pulse oximetry, near-infrared spectroscopy [NIRS]) will be utilized to measure changes in arterial oxyhemoglobin saturation and skeletal muscle oxygenation at the level of the microvasculature during exercise. It is expected that after Cetirizine, blood and muscle microvascular oxygenation during heavy exercise will improve compared to placebo, ultimately improving exercise performance at altitude. Subjects will be asked to report to the laboratory on a three occasions, separated by a minimum of 48 hours and a maximum of 14 days. For each subject, all testing sessions will be performed at the same time of day. Prior to each testing session, subjects will be asked to abstain from caffeine consumption for 12 hours. Subjects will also be asked to avoid alcohol consumption for 24 hours before testing, be at least 3-hour post prandial and avoid high-intensity exercise during the 24 hours leading to the exercise testing. Finally, subjects will be asked to consume a similar diet the night before, and the morning of, Sessions 2 and 3. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03192488
Study type	Interventional
Source	Indiana University
Contact
Status	Completed
Phase	Phase 4
Start date	August 31, 2017
Completion date	June 6, 2018

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03728595` - Validation of a Predictive Score for HAST
Recruiting	`NCT06171841` - Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions	N/A
Completed	`NCT03135314` - Cocoa Flavanol Intake and Exercise in Hypoxia	N/A
Completed	`NCT03541993` - The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.	N/A
Completed	`NCT04075565` - The Psychophysiological Effect of Simulated and Terrestrial Altitude	N/A
Completed	`NCT05584813` - Colour Vision Impairment During Acute Hypobaric Hypoxia	N/A
Completed	`NCT03823677` - Analysis of Protein and Emotional Alterations During and After Hypobaric Hypoxia	N/A
Completed	`NCT04089410` - Direct and Cross Effects of Adaptation to Systemic Hyperthermia: Impact on Quality of Life, Neurohormonal and Psychophysiological Human Status	N/A
Completed	`NCT05167357` - Coronaltitude - Multicentric Evaluation of the Impact on Hypoxia Sensitivity of Patients With COVID-19	N/A
Recruiting	`NCT06159374` - Effects of Physical Training in Altered Environmental Conditions on Exercise Performance	N/A
Recruiting	`NCT04251364` - Treatment of Chronic Mountain Sickness	N/A
Completed	`NCT03976986` - Assessment of Portable Oxygen Concentrators in Infants Undergoing Hypoxic Challenge Testing.	N/A
Recruiting	`NCT06204731` - The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males	N/A
Not yet recruiting	`NCT06121128` - The Effects of Inspiratory Muscle Training on Endurance Performance in Trained Athletes Under Normoxic and Hypoxic Conditions: A Gender-based Comprehensive Study	N/A
Completed	`NCT03335917` - Oxygen Transport in Normobaric vs. Hypobaric Hypoxia	N/A
Completed	`NCT02871063` - Effect of Altitude on the Evolution of Acute Respiratory Distress Syndrome	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.