Brain Clinical Trial
Official title:
The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at 4000 m Stimulated Altitude and at Sea Level: A Double Blind, Crossover Investigation.
Background: Vaso-active polyphenols have been proposed to enhance cognitive performance. Oral
administration with the non-flavonoid polyphenol, resveratrol, has been found to modulate
cerebral blood flow (CBF); yet, this has not resulted in subsequent predicted benefits to
cognitive performance in young, healthy samples. It has been argued that ageing populations
who are noted suffer a reduction in CBF and cognition, may possess the subtle deficits to
benefit from resveratrol administration. The use of hypoxia has been previously tested by
this research group to mimic the decrease in cognitive functioning associated with ageing.
Objectives: The current investigation aimed to further assess if a reduced fraction of
inspired oxygen (12.7% FiO2) could provide an experimental model of aging in a young, healthy
sample. Moreover, the current study also aimed to assess if resveratrol can attenuate the
deficits elicited by the reduction in oxygen supply via increased CBF.
Design: This repeated measures, double blind, placebo controlled, balanced design assessed
the cognitive and CBF effects of resveratrol in hypoxia (equivalent to 4000 m above sea
level) and normoxia (sea level).
Methods: Twenty-four participants arrived fully fasted (except water) for 12 hours before
completing a baseline measure of a cognitive task battery, and taking the treatment for the
day (either 500 mg resveratrol or inert placebo). Following a 45 min absorption period,
participants completed 3 full repetitions of a cognitive test battery. Changes in cerebral
hemodynamics were measured by near-infrared spectroscopy throughout the full testing session.
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