Hypoxia, Altitude Clinical Trial
Official title:
Acetazolamide and Statins for the Treatment of Chronic Mountain Sickness in Highlanders: A Randomized Controlled Trial
This study aims to assess the effect of two drugs for the treatment of chronic mountain sickness in highlanders.
About 100 million individuals reside at high altitude (>2500m) worldwide, with the largest populations of highlanders being found in South America (Andean), central Asia (Tibetan and Sherpa) and East Africa (Ethiopian). Despite unique adaptations to hypoxia in these populations, chronic mountain sickness (CMS) is a clinical syndrome which is observed in 5-33% of individuals residing permanently at high altitude.Several pharmacological approaches have been proposed in the treatment of EE and CMS. However, few studies show sufficient clinical evidence for safety and efficacy in CMS treatment and most highlanders with CMS remain untreated. The present project aims to better characterize chronic hypoxic responses in highlanders and to evaluate the interest of acetazolamide and statins as potential treatments for chronic mountain sickness. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03728595 -
Validation of a Predictive Score for HAST
|
||
| Recruiting |
NCT06171841 -
Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions
|
N/A | |
| Completed |
NCT03135314 -
Cocoa Flavanol Intake and Exercise in Hypoxia
|
N/A | |
| Completed |
NCT03541993 -
The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.
|
N/A | |
| Completed |
NCT04075565 -
The Psychophysiological Effect of Simulated and Terrestrial Altitude
|
N/A | |
| Completed |
NCT05584813 -
Colour Vision Impairment During Acute Hypobaric Hypoxia
|
N/A | |
| Completed |
NCT03823677 -
Analysis of Protein and Emotional Alterations During and After Hypobaric Hypoxia
|
N/A | |
| Completed |
NCT04089410 -
Direct and Cross Effects of Adaptation to Systemic Hyperthermia: Impact on Quality of Life, Neurohormonal and Psychophysiological Human Status
|
N/A | |
| Completed |
NCT05167357 -
Coronaltitude - Multicentric Evaluation of the Impact on Hypoxia Sensitivity of Patients With COVID-19
|
N/A | |
| Recruiting |
NCT06159374 -
Effects of Physical Training in Altered Environmental Conditions on Exercise Performance
|
N/A | |
| Completed |
NCT03976986 -
Assessment of Portable Oxygen Concentrators in Infants Undergoing Hypoxic Challenge Testing.
|
N/A | |
| Recruiting |
NCT06204731 -
The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males
|
N/A | |
| Not yet recruiting |
NCT06121128 -
The Effects of Inspiratory Muscle Training on Endurance Performance in Trained Athletes Under Normoxic and Hypoxic Conditions: A Gender-based Comprehensive Study
|
N/A | |
| Completed |
NCT03192488 -
Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia
|
Phase 4 | |
| Completed |
NCT03335917 -
Oxygen Transport in Normobaric vs. Hypobaric Hypoxia
|
N/A | |
| Completed |
NCT02871063 -
Effect of Altitude on the Evolution of Acute Respiratory Distress Syndrome
|
N/A |