Hypoxia, Altitude Clinical Trial
Official title:
Assessment of Portable Oxygen Concentrators in Infants Undergoing Hypoxic Challenge Testing. A Randomized Crossover Study.
Hypoxic Challenge Testing (HCT) is the recommended method for inflight hypoxia risk assessment. Onboard oxygen administration remains controversial. The Federal Aviation Administration approved portable oxygen concentrators (POCs) for onboard oxygen supply but there is lack of evidence about the use, especially in children. The aim of our study is to establish the effectiveness and safety of POCs in infants undergoing HCT.
According to a forecast by International Air Transport Association the number of people travelling on commercial aircrafts is predicted to rise up to 8.2 billion passengers in 2037. Therefore evidence-based flight recommendations will gain importance in the future, especially for patients suffering from chronic diseases. Hypoxic Challenge Testing (HCT) is the recommended method for inflight hypoxia risk assessment where nitrogen is introduced in a plethysmograph reducing FiO2 (fraction of inspired oxygen) to 0.15. Oxygen supply is recommended if PaO2 (partial pressure of oxygen in arterial blood) drops <50-55 mmHg (in adults) or Sat.O2 (oxygen saturation) ≤ 85% (in infants) where non-invasive pulse oximetry is the recommended method for hypoxia assessment. Onboard oxygen administration remains controversial. The effectiveness of pulsed-dosed systems remains unclear in small patients due to shallow breathing patterns. The aim of our study is to establish the effectiveness and safety of POCs in infants undergoing HCT. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03728595 -
Validation of a Predictive Score for HAST
|
||
Active, not recruiting |
NCT06171841 -
Effects of Low-Intensity Blood Flow Restriction Training in Normoxia and Hypoxia Conditions
|
N/A | |
Completed |
NCT03135314 -
Cocoa Flavanol Intake and Exercise in Hypoxia
|
N/A | |
Completed |
NCT03541993 -
The Cerebral Hemodynamic and Cognitive Effects of Acute Resveratrol Administration in Young, Healthy Adults at Stimulated Altitude.
|
N/A | |
Completed |
NCT04075565 -
The Psychophysiological Effect of Simulated and Terrestrial Altitude
|
N/A | |
Completed |
NCT05584813 -
Colour Vision Impairment During Acute Hypobaric Hypoxia
|
N/A | |
Completed |
NCT03823677 -
Analysis of Protein and Emotional Alterations During and After Hypobaric Hypoxia
|
N/A | |
Completed |
NCT04089410 -
Direct and Cross Effects of Adaptation to Systemic Hyperthermia: Impact on Quality of Life, Neurohormonal and Psychophysiological Human Status
|
N/A | |
Completed |
NCT05167357 -
Coronaltitude - Multicentric Evaluation of the Impact on Hypoxia Sensitivity of Patients With COVID-19
|
N/A | |
Recruiting |
NCT06159374 -
Effects of Physical Training in Altered Environmental Conditions on Exercise Performance
|
N/A | |
Recruiting |
NCT04251364 -
Treatment of Chronic Mountain Sickness
|
N/A | |
Recruiting |
NCT06204731 -
The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males
|
N/A | |
Not yet recruiting |
NCT06121128 -
The Effects of Inspiratory Muscle Training on Endurance Performance in Trained Athletes Under Normoxic and Hypoxic Conditions: A Gender-based Comprehensive Study
|
N/A | |
Completed |
NCT03192488 -
Effect of an H1 Receptor Antagonist on Exercise Performance in Hypoxia
|
Phase 4 | |
Completed |
NCT03335917 -
Oxygen Transport in Normobaric vs. Hypobaric Hypoxia
|
N/A | |
Completed |
NCT02871063 -
Effect of Altitude on the Evolution of Acute Respiratory Distress Syndrome
|
N/A |