Hypertension Clinical Trial
— TAHOCOfficial title:
The Impact of Dementia and Neurocognitive Disorders on Hypertension Treatment in the Very Elderly: the TAHOC Study
NCT number | NCT05845736 |
Other study ID # | 2023PI017 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | January 1, 2022 |
Est. completion date | December 12, 2022 |
Verified date | May 2023 |
Source | Central Hospital, Nancy, France |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Neurocognitive disorders and hypertension occur commonly with aging. While, by definition, older adults are at high cardiovascular risk, there is no guideline exist currently on blood pressure management of elderly hypertension. However, studies have shown that in aging adults, high blood pressure helps prevent against cognitive decline, and low blood pressure on antihypertensive drugs could accelerate it. This study aims at investigating if pharmacological treatment of hypertension in the very elderly is influenced by presence and severity of neurocognitive disorders. Our research hypothesis is that the drug management of hypertension in patients 80 years of age or older more is all the less aggressive as the neurocognitive disorders are advanced.
Status | Completed |
Enrollment | 353 |
Est. completion date | December 12, 2022 |
Est. primary completion date | January 1, 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 80 Years and older |
Eligibility | Inclusion Criteria: - to be 80 years of age - with history of hypertension and/or on hypertensive drug(s) Exclusion Criteria: - legal protection measure. |
Country | Name | City | State |
---|---|---|---|
France | Centre Hospitalier Régional Universitaire de Nancy | Nancy |
Lead Sponsor | Collaborator |
---|---|
Central Hospital, Nancy, France |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | number of antihypertensive agents | among ACEI/ARB2, calcium channel blocker, thiazides and related, central antihypertensive beta blocker | during inclusion | |
Secondary | class of antihypertensive medications | among ACEI/ARB2, calcium channel blocker, thiazides and related, central antihypertensive beta blocker | during inclusion | |
Secondary | systolic and diastolic blood pressure | blood pressure measured with upper arm cuffs | during inclusion | |
Secondary | orthostatic hypotension | a systolic blood pressure decrease of at least 20 mm Hg or a diastolic blood pressure decrease of at least 10 mm Hg within three minutes of standing | during inclusion |
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