Hypertension,Essential Clinical Trial
Official title:
Licorice and Home Blood Pressure: a Randomized Crossover Trial
Verified date | August 2023 |
Source | Linkoeping University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Out-of-office blood pressure is more strongly associated with cardiovascular risk than office blood pressure. Licorice is known to raise blood pressure, but no previous studies have measured the effects on home blood pressure. The aim of this study is to analyze the association between licorice intake and home blood pressure.
Status | Completed |
Enrollment | 28 |
Est. completion date | June 30, 2023 |
Est. primary completion date | June 30, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 30 Years |
Eligibility | Inclusion Criteria: - Age 18 to 30 years Exclusion Criteria: - known hypertension, cardiovascular disease, kidney disease, liver disease, hormonal disease, peanut allergy, eating disorder or headache disease (including tension headache and migraine) - known alcohol abuse or drug abuse (including cannabis and anabolic steroids) - treatment with hormonal drugs (including oral contraceptives - known intolerance to licorice intake |
Country | Name | City | State |
---|---|---|---|
Sweden | Cityhälsan Centrum | Norrköping | Östergötland |
Lead Sponsor | Collaborator |
---|---|
Linkoeping University |
Sweden,
Deutch MR, Grimm D, Wehland M, Infanger M, Kruger M. Bioactive Candy: Effects of Licorice on the Cardiovascular System. Foods. 2019 Oct 14;8(10):495. doi: 10.3390/foods8100495. — View Citation
Parati G, Stergiou GS, Bilo G, Kollias A, Pengo M, Ochoa JE, Agarwal R, Asayama K, Asmar R, Burnier M, De La Sierra A, Giannattasio C, Gosse P, Head G, Hoshide S, Imai Y, Kario K, Li Y, Manios E, Mant J, McManus RJ, Mengden T, Mihailidou AS, Muntner P, Myers M, Niiranen T, Ntineri A, O'Brien E, Octavio JA, Ohkubo T, Omboni S, Padfield P, Palatini P, Pellegrini D, Postel-Vinay N, Ramirez AJ, Sharman JE, Shennan A, Silva E, Topouchian J, Torlasco C, Wang JG, Weber MA, Whelton PK, White WB, Mancia G; Working Group on Blood Pressure Monitoring and Cardiovascular Variability of the European Society of Hypertension. Home blood pressure monitoring: methodology, clinical relevance and practical application: a 2021 position paper by the Working Group on Blood Pressure Monitoring and Cardiovascular Variability of the European Society of Hypertension. J Hypertens. 2021 Sep 1;39(9):1742-1767. doi: 10.1097/HJH.0000000000002922. — View Citation
Rizzato G, Scalabrin E, Radaelli M, Capodaglio G, Piccolo O. A new exploration of licorice metabolome. Food Chem. 2017 Apr 15;221:959-968. doi: 10.1016/j.foodchem.2016.11.068. Epub 2016 Nov 17. — View Citation
Spinks EA, Fenwick GR. The determination of glycyrrhizin in selected UK liquorice products. Food Addit Contam. 1990 Nov-Dec;7(6):769-78. doi: 10.1080/02652039009373939. — View Citation
Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I; Authors/Task Force Members:. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018 Oct;36(10):1953-2041. doi: 10.1097/HJH.0000000000001940. Erratum In: J Hypertens. 2019 Jan;37(1):226. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Systolic home blood pressure (mmHg) | Systolic home blood pressure (mmHg) | Mean at the end of 14 days of intervention compared with mean during run-in period | |
Primary | Diastolic home blood pressure (mmHg) | Diastolic home blood pressure (mmHg) | Mean at the end of 14 days of intervention compared with mean during run-in period | |
Secondary | Body weight (kg) | Body weight (kg) | Mean at the end of 14 days of intervention compared with mean during run-in period | |
Secondary | Plasma potassium (mmol/L) | Plasma potassium (mmol/L) | Mean at the end of 14 days of intervention compared with mean during run-in period | |
Secondary | Plasma sodium (mmol/L) | Plasma sodium (mmol/L) | Mean at the end of 14 days of intervention compared with mean during run-in period | |
Secondary | Plasma renin (mIU/L) | Plasma renin (mIU/L) | Mean at the end of 14 days of intervention compared with mean during run-in period | |
Secondary | Serum aldosterone (µmol/L) | Serum aldosterone (µmol/L) | Mean at the end of 14 days of intervention compared with mean during run-in period |
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