Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans

Hypertension Clinical Trial

Official title:

The Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans: A Cross-Sectional Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05344287
• Other study ID #: 2019-0318
• Status: Completed
• Start date: July 12, 2019
• Est. completion date: January 13, 2020

Study information

• Verified date: April 2022
• Source: The University of Texas at Arlington
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood. Therefore, this project will investigate whether African Americans following a 100% plant-based diet have more optimal blood pressure, vascular function, and blood lipid profiles, along with lower systemic inflammation relative to African Americans following a typical American diet.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 19
• Est. completion date: January 13, 2020
• Est. primary completion date: January 13, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Self-identify as African American/Black

• Self-reported adherence to either a typical American diet (not following a specific diet pattern) or 100% plant-based (vegan) diet

• Age 18-40

Exclusion Criteria:

• History of smoking within 2 years or being a current smoker

• Taking vasoactive medications

• Having overt cardiovascular, metabolic, or neurological disease

• Pregnant individuals

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Diet, Healthy
• Hypertension

Intervention

Other:
• Typical American Diet
Participants self-reported adherence to a typical American diet prior to enrolling in the study. This factor determined cross-sectional group allocation.
• Plant-Based Diet
Participants self-reported adherence to a 100% plant-based diet prior to enrolling in the study. This factor determined cross-sectional group allocation.

Locations

Country	Name	City	State
United States	UT Arlington - Science and Engineering Innovation and Research Building	Arlington	Texas

Sponsors (1)

Lead Sponsor	Collaborator
The University of Texas at Arlington

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Lipid profile (Total-C, LDL-C, VLDL-C, HDL-C, TG)		Day 1
Primary	C-reactive protein		Day 1
Primary	Post-occlusive brachial artery flow-mediated dilation (% change in brachial artery diameter from resting baseline)		Day 1
Primary	Post-occlusive forearm reactive hyperemia (% change in brachial artery blood velocity from resting baseline)		Day 1
Primary	Pulse wave velocity (carotid-to-femoral)		Day 1
Primary	Augmentation index (AIx@HR75)		Day 1
Primary	Cerebral vascular reactivity (% change in cerebrovascular conductance index from resting baseline)		Day 2
Primary	Local cutaneous thermal hyperemia (% change in cutaneous vascular conductance from resting baseline)		Day 2
Primary	Peripheral blood pressure (systolic, diastolic, mean)		Day 1
Primary	Central blood pressure (systolic, diastolic, mean)		Day 1