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Clinical Trial Summary

This study is a mechanistic clinical trial designed to investigate the effects of the circadian system and sleep on non-dipping blood pressure in people with hypertension.


Clinical Trial Description

This study is a mechanistic clinical trial designed to study the effects of the circadian system and sleep on non-dipping blood pressure in people with hypertension. We will study participants with dipping and non-dipping hypertension. All participants will partake in all experiments. First, we will assess sleep in the participants' home environment using unattended polysomnography. Participants will then complete a 5-day overnight forced desynchrony laboratory protocol to uncover circadian rhythms (Constant Routine). The second experiment is a randomized crossover protocol. Two trials (Overnight Sleep and Rested Wakefulness) will be completed in randomized order to separate the effects of sleep on non-dipping blood pressure while assessing nighttime cardiovascular mechanisms. Finally, we will pilot test if 2 weeks of sleep regularization impacts 24-hour BP. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05184933
Study type Interventional
Source Oregon Health and Science University
Contact Nicole Chaudhary, MPH
Phone 5034945536
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date April 1, 2022
Completion date December 15, 2030

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