Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure

Hypertension,Essential Clinical Trial

— DIISCCO  

Official title:

Effect of High-Intensity Interval Training Compared to Hydrochlorothiazide on Ambulatory Blood Pressure, Cardiovascular Health, Cognition and Mobility in Pre-Hypertensive Older Adults.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04103411
• Other study ID #: 2018-2319
• Status: Recruiting
• Phase: N/A
• Start date: April 26, 2018
• Est. completion date: January 10, 2022

Study information

• Verified date: September 2019
• Source: Montreal Heart Institute
• Contact: Anil Nigam, MD
• Phone: 514-376-3330
• Email: anil.nigam[@]icm-mhi.org
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The number of persons with hypertension is increasing and with it the number of related cardiovascular events and related functional or cognitive declines. While studies have suggested that physical activity, in particular, high-intensity interval training (HIIT), could be as efficient as the commonly used antihypertensive medications, no studies have actually compared their effects in the same population. This protocol will determine if HIIT is at least as efficient as hydrochlorothiazide in order to lower 24h-ambulatory blood pressure (BP) in prehypertensive older adults.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: January 10, 2022
• Est. primary completion date: June 1, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

1. Age at consent = 60 years;

2. Systolic Blood pressure measured through BPtru™ between SBP = 120 mmHg and < 140 and or DBP = 80 mmHg

3. Being able to sign the informed consent form

Exclusion Criteria:

1. Considered "highly active" according to the International Physical Activity Questionnaire

2. Practicing more than 20 min per week of High-Intensity Interval Training

3. Use of antihypertensive medication

4. Contraindication for the practice of intense physical activity

5. Functional limitations related to the exercise test and to intensive training

6. Cardiovascular pathology

7. Atrial fibrillation

8. Psychiatric or neurological disorder

9. Renal failure

10. MMSE score < 26

11. Persons benefiting of enhanced protection: persons deprived of their liberty by a judicial or administrative decision, persons staying in a health or social institution, adults under legal protection and patients in emergency situations.

12. Diabetes

Related Conditions & MeSH terms

• Essential Hypertension
• Exercise Activity
• Hypertension,Essential

Intervention

Other:
• 24h-Ambulatory Blood Pressure
Effect of High Intensity Interval Training compared to Hydrochlorothiazide on ambulatory Blood Pressure.

Locations

Country	Name	City	State
Canada	Cardiovascular Prevention and Rehabilitation Center	Montreal	Quebec

Sponsors (1)

Lead Sponsor	Collaborator
Anil Nigam

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	24h-Ambulatory Blood Pressure	The 24-hour ambulatory measure of the blood pressure (AMBP)	At baseline and after twelve weeks of intervention
Secondary	Cardiovascular evaluation	Maximum incremental cardiopulmonary exercise test (VO2MAX)	Before and after twelve weeks of intervention
Secondary	Cognitive functions	Cognitive functions will be measured at rest with a pen-paper battery test by a neuropsychologist. The investigators will measure change of score to the cognitive tests.	Before and after twelve weeks of intervention
Secondary	Flow Mediated Dilatation (FMD)	Percentage of dilatation of the brachial artery	Before and after twelve weeks of intervention