Association Between Coronary Flow Reserve & BH4 Levels in High CV Risk

Status Completed

Clinical Trial Summary

To determine if there is a relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with high cardiovascular risk .

Clinical Trial Description

Primary parameter :

relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with hypertension and concomitant cardiovascular risk factors.

Secondary parameter:

Levels of cGMP in platelets.

4. Study design

Three parallel groups of patients (n=15 per group):

- Group 1 with normal coronary flow reserve (CFR ≥2.5)

- Group 2 with reduced coronary flow reserve (CFR≤2.0)

o Group 3 control subjects (without a high risk profile according to ESC score chart http://www.heartscore.org. ) matched for age (between 40 and 80 years of age)

- and gender. 1/3 enrolled patients must be diabetic (Type2 diabetes) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03841383
Study type	Observational
Source	IRCCS San Raffaele
Contact
Status	Completed
Phase
Start date	June 6, 2017
Completion date	July 10, 2019

View Details

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Association Between Coronary Flow Reserve and BH4 Levels in High CV Risk

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms