Hypertension Clinical Trial
— HemodialysisOfficial title:
Effects of a Program of Strength Physical Activities on the Expression of Nrf2 and Nf-kb Hemodialysis Patients
NCT number | NCT02718638 |
Other study ID # | DeniseMafra2 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | January 2013 |
Est. completion date | October 2020 |
Verified date | October 2020 |
Source | Universidade Federal Fluminense |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Oxidative stress and inflammation are cardiovascular risk factors in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). Nuclear transcription factors play roles in the coordinated expression of genes involved in inflammation, such as nuclear factor Kappa B (NFkB) that increase the cytokines synthesis and Nuclear factor erythroid 2-related factor 2 (Nrf2) that increase the transcription of genes encoding enzymes of phase II detoxifying and antioxidant enzymes. The aim of this study was to evaluate the effects of resistance exercise program on the expression of transcription factors Nrf2 and NF-kB in HD patients.
Status | Completed |
Enrollment | 40 |
Est. completion date | October 2020 |
Est. primary completion date | November 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - Inclusion criteria were age >18 years - Without any motor skill disorders, arteriovenous fistula for vascular access in the upper limb and patients on maintenance dialysis for at least 6 months. Exclusion Criteria: - Patients with autoimmune diseases, cancer, infectious diseases, acquired immunodeficiency syndrome, uncontrolled hypertension, unstable angina, malignant arrhythmias, pregnant, lower limb amputee, history of stroke, neurological or cardiovascular disease (moderate-intensity physical activity is not routinely recommended) - Taking catabolizing drugs - Under regular exercise - Smokers - Patients who complied with <75 % of the training were excluded. |
Country | Name | City | State |
---|---|---|---|
Brazil | Denise Mafra | Rio de Janeiro | RJ |
Lead Sponsor | Collaborator |
---|---|
Universidade Federal Fluminense |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in Nrf2 expression | analysed by PCR real time | changes in Nrf2 expression from baseline and 3 months | |
Primary | Changes in cytokines plasma levels | cytokines plasma levels like interleukin-6, TNF-alpha evaluated by ELISA methods | changes in cytokines plasma levels from baseline and 3 months |
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