Hypertension Clinical Trial
Official title:
A Double Blind, Randomized Placebo-controlled Cross-over Study on the Cardiovascular Effects of Salvia Miltiorrhiza Extract (Danshen) in Patients With Hypertension and Hyperlipidemia.
Rationale: Extracts of the plant Salvia miltiorrhiza (Danshen) have been used as traditional
Chinese medicine in the treatment of cardiovascular diseases, such as angina pectoris and
myocardial infarction. Several preclinical studies point towards promising effects of
Danshen on risk factors of atherosclerotic cardiovascular diseases, such as hyperlipidemia
and hypertension.
Objective: Our primary objective is to determine the effect of Salvia miltiorrhiza extract
(Danshen) on hyperlipidemia. Secondary objective is to investigate the effect of Danshen on
hypertension. Further objectives are to determine its effect on endothelial function,
oxidative stress, inflammation, hemostasis and hemorheology, and on insulin sensitivity.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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