Hypertension Clinical Trial
Official title:
Systolic Pressure Intervention Trial (SPRINT)-Factors Affecting Factors Affecting Atherosclerosis Study (FAST)
Systolic Pressure Intervention Trial (SPRINT) is a large scale randomized trial of ~ 9250
adults aged 50 years or older with high cardiovascular risk sponsored by NIH. The study is
designed to recruit 45% of the study population with Chronic Kidney Disease (CKD). The trial
will test the effects of low systolic blood pressure (SBP) goal of < 120 mm Hg versus the
standard goal of < 140 mm Hg on the primary composite of cardiovascular events and death. One
of the pre-specified secondary outcome is the progression of kidney disease. In this
ancillary named SPRINT - Factors affecting Atherosclerosis STudy (FAST), the investigators
plan to take advantage of the unique opportunities afforded by the parent study to examine
issues that are of significant public health importance.
This is an observational study in SPRINT participants. This study will examine
mechanistically, the factors affecting the progression of atherosclerosis in CKD.
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