Hypertension Clinical Trial
Official title:
Effects of Strength Training and Walking Training on Physical Fitness of Patients With Intermittent Claudication
Background: Muscle atrophy and reduced leg strength are related to exercise intolerance in
patients with intermittent claudication (IC), suggesting that strength training (ST) could
improve exercise performance in these patients.
Objective: Analyze the effects of ST in walking capacity in patients with IC comparing with
walking training (WT) effects.
Intervention: Patients were randomized into ST and WT. Both groups trained twice a week, for
12 weeks, at the same rate of perceived exertion. ST consisted of 3 sets of 10 repetitions
of whole body exercises. WT consisted of 15 two-minute bouts of walking intercalated with 2
minutes of resting.
Measurements: Walking capacity, peak VO2, walking economy, ankle brachial index, ischemic
window and knee extension strength
From July 2005 to December 2006, three hundred patients with peripheral arterial disease,
who were enrolled in a tertiary center specialized in vascular disease and were able to walk
for at least 2 minutes at 2 miles per hour, were invited to a meeting at which explanations
about this study were given. 80 patients attended the meeting, 60 of them decided to take
part of the study, and 52 attended for the screening tests.
Patients were included in the study if they met the following criteria: Fontaine stage II
peripheral arterial disease, symptoms of IC for at least 6 months, ankle/brachial index
(ABI) at rest ≤ 0.90 in 1 or 2 legs, reduction of ABI after treadmill test, and exercise
tolerance limited by IC. Patients were excluded under the following conditions: presence of
chronic lung disease, inability to obtain ABI measurement due to noncompressible vessels,
exercise tolerance limited by factors other than claudication (eg, dyspnea or orthopedic
problems), poorly controlled blood pressure, presence of electrocardiogram response
suggestive of myocardial ischemia during the exercise test, and history of revascularization
in the previous year.
Procedures Patients were randomly (by drawing lots) divided into 2 groups: strength (ST, n =
17) and walking (WT, n = 17) training. They were evaluated at baseline (pre-training) and
after 12 weeks of exercise training (post-training). During evaluations were assessed
exercise tolerance and strength.
Both training programs (ST and WT) were supervised, conducted twice a week, lasted for 12
weeks, and started after a 2-week preconditioning-orientation phase. In both programs, rate
of perceived exertion during exercise was kept similar and between 11 to 13 on the15-grade
Borg scale. Furthermore, the duration of exercise sessions was prescribed as 30 min of
exercise for ST and WT groups.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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