Hypertension Clinical Trial
Official title:
A Multi-Center, Double-Blind, Randomized Study Comparing the Efficacy of Combination Therapy of Eprosartan Respectively Ramipril With Low-Dose Hydrochlorothiazide and Moxonidine on Blood Pressure Levels in Patients With Hypertension and Associated Diabetes Mellitus Type 2
This study is to demonstrate the superiority of combination of eprosartan/HCTZ versus ramipril/HCTZ.
| Status | Completed |
| Enrollment | 440 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 40 Years to 80 Years |
| Eligibility |
Inclusion Criteria: - essential hypertension, - diabetes type 2 Exclusion Criteria: - severe cardiovascular disease, - grade 3 hypertension, - secondary hypertension, - abnormal liver enzymes |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
| Country | Name | City | State |
|---|---|---|---|
| Canada | Site 26 | Calgary | |
| Canada | Site 27 | Montreal | |
| Canada | Site 30 | Quebec | |
| Canada | Site 31 | Thornhill | |
| Canada | Site 28 | Vancouver | |
| Canada | Site 29 | Winnipeg | |
| Denmark | Site 39 | Holbaek | |
| Denmark | Site 38 | Roskilde | |
| Denmark | Site 40 | Viborg | |
| France | Site 4 | Anzin | |
| France | Site 3 | Blois | |
| France | Site 10 | Chemellier | |
| France | Site 11 | Cholet | |
| France | Site 15 | Cholet | |
| France | Site 16 | Cholet | |
| France | Site 14 | La Jubaudiere | |
| France | Site 13 | Le Mesnil-en-Vallee | |
| France | Site 7 | Murs-Erigne | |
| France | Site 9 | Saumur | |
| France | Site 8 | Segre | |
| France | Site 12 | St Pierre Montlim | |
| France | Site 6 | Thouars | |
| France | Site 2 | Tours | |
| France | Site 5 | Vieux Conde | |
| Germany | Site 20 | Bad Muenster | |
| Germany | Site 22 | Floersheim | |
| Germany | Site 19 | Kirweiler | |
| Germany | Site 21 | Lambrecht | |
| Germany | Site 25 | Lindau | |
| Germany | Site 18 | Lueneburg | |
| Germany | Site 24 | Lutherstadt | |
| Germany | Site 17 | Riesa | |
| Germany | Site 23 | Waldbrunn | |
| Italy | Site 62 | Bologna | |
| Italy | Site 60 | Napoli | |
| Italy | Site 58 | Padova | |
| Italy | Site 59 | Palermo | |
| Italy | Site 63 | Pavia | |
| Italy | Site 61 | Pisa | |
| Italy | Site 64 | Torino | |
| Norway | Site 43 | Alesund | |
| Norway | Site 42 | Bergen | |
| Norway | Site 44 | Horten | |
| Norway | Site 41 | Skedsmokorset | |
| Spain | Site 55 | Badajoz | |
| Spain | Site 51 | Badalona | |
| Spain | Site 56 | Barcelona | |
| Spain | Site 57 | Barcelona | |
| Spain | Site 54 | Ciudad Real | |
| Spain | Site 53 | Granada | |
| Spain | Site 52 | Madrid | |
| Sweden | Site 48 | Angelholm | |
| Sweden | Site 47 | Goteburg | |
| Sweden | Site 46 | Helsingborg | |
| Sweden | Site 45 | Kristianstat | |
| Sweden | Site 50 | Malmo | |
| Sweden | Site 49 | Stockholm | |
| United Kingdom | Site 33 | Aberdeen | |
| United Kingdom | Site 36 | Bath | |
| United Kingdom | Site 37 | Liverpool | |
| United Kingdom | Site 34 | Manchester | |
| United Kingdom | Site 32 | Oldham | |
| United Kingdom | Site 35 | Rugby |
| Lead Sponsor | Collaborator |
|---|---|
| Solvay Pharmaceuticals |
Canada, Denmark, France, Germany, Italy, Norway, Spain, Sweden, United Kingdom,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Blood pressure reduction | |||
| Secondary | Comparison of responder rates |
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