Hypertension Clinical Trial
To help clarify the validity, reliability, and utility of blood pressure (BP) and lipid screening in childhood.
BACKGROUND:
To be useful, a screening program depends on an acceptable, valid, and reliable test, and an
efficacious and cost-effective intervention in the population of interest. Screening
children to detect those at high risk of adult hypertension or hypercholesterolemia was
examined from this viewpoint. Long-term studies starting in childhood have so far revealed
less than optimal validity of blood pressure and serum cholesterol levels in childhood as
predictors of adult levels. However, information was sparse regarding reliability of
measurements, accounting for which could improve validity. The efficacy of interventions
that could be widely applied in childhood had not yet been demonstrated. In addition, the
costs of an extensive screening program and risks such as misclassification, side effects,
and labeling needed to be evaluated. The results of this study helped determine whether
screening for risk factors in childhood was a useful method for preventing cardiovascular
disease in adults.
DESIGN NARRATIVE:
The study examined the following factors that were key elements in the evaluation of
screening: 1) within-person variability of BP and lipid measurements (i.e., the reliability
of the test) and its impact on tracking of BP and lipids from childhood to adulthood, 2)
calculation of predictive values, sensitivity, and specificity of childhood BP and lipid
measurements considered as screening tests for adult values, after correcting for
within-person variability (i.e., validity), 3) one potentially effective intervention for BP
control in children, that is, calcium supplementation, and 4) evaluating the
cost-effectiveness of screening to identify children at high risk of developing adult
hypertension or hyperlipidemia.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) recor
;
N/A
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