Hypertension Clinical Trial
To determine the role of the prorenin-renin-angiotensin-aldosterone system (RAAS) in normal and hypertensive pregnancy.
BACKGROUND:
The renin-angiotensin system is involved in the physiology of pregnancy in two ways.
Circulating angiotensin II affects blood pressure, renal hemodynamics, and uteroplacental
blood flow. Abnormalities in angiotensin II production rates in hypertensive pregnancy
contribute to the hemodynamic changes seen in the disease. Additionally, there is a form of
the renin-angiotensin system in kidney, ovary, and placenta whose function is regulated by
prorenin. Prorenin, activated by a specific receptor, is involved in the regulation of
steroid hormone biosynthesis and renal and uteroplacental blood flow.
The study was conducted in response to a Request for Applications on Research on
Hypertension in Pregnancy jointly released in 1986 by the National Heart, Lung, and Blood
Institute and the National Institute of Child Health and Human Development.
DESIGN NARRATIVE:
The study was longitudinal in design. Measurements were made of glomerular filtration rate,
renal plasma flow or uterine blood flow. To define first trimester changes, studies were
conducted on in vitro fertilization and ovarian failure patients who had a broad spectrum of
plasma prorenins. Since interrelated changes in renin and prostaglandins may participate in
the pathogenesis of hypertensive pregnancy, RAAS, prostaglandins, and uteroplacental flow
velocity profiles were monitored during a placebo-controlled trial of low-dose aspirin in
chronic hypertensives.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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