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Hypertension clinical trials

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NCT ID: NCT00327574 Active, not recruiting - Obesity Clinical Trials

Population Based Strategies for Effective Control of High Blood Pressure in Pakistan

Start date: June 2004
Phase: N/A
Study type: Interventional

Studies have established that high blood pressure (BP) is the most common risk factor for cardiovascular disease (CVD). Despite a heavy burden of hypertension (33% of all persons aged 45 years and over), there are no reliable data on comparative strategies to manage hypertension in Pakistan. Our Wellcome Trust funded pilot study in Karachi, Pakistan on 320 adults aged 40 years and over showed that the prevalence of hypertension (95% CI) was 40.3% (34.9-45.7%), and CVD was 32.5% (27.6-37.8%). We will now conduct a study with two components: 1) cross sectional study to determine the prevalence of CVD, and its determinants in Karachi, Pakistan; and 2) prospective, 2x2 factorial design, cluster allocation intervention study to evaluate the impact of a i) Population approach of household health education (HHE) by community health workers (CHW) on BP levels of population aged 5 years or over in low-middle income communities of Karachi; and ii) High-Risk approach of special BP management administered by intensively trained local general practitioners on BP levels of hypertensive subjects aged > = 40 years from the above population. The cost effective BP control strategy would serve as a model for a much-needed national level hypertension control programme in Pakistan, and possibly other developing countries in South Asia. We hypothesize that 1) HHE delivered by trained CHW is superior to no HHE in lowering BP levels of the population; and 2) management of hypertension by specially trained GPs is better than usual care provided in the communities of Karachi in lowering blood pressure of hypertensive subjects.

NCT ID: NCT00289705 Active, not recruiting - Obesity Clinical Trials

Surgical Intervention for Morbidly Obese Adolescents

Start date: February 2006
Phase: Phase 3
Study type: Interventional

The purpose is to study whether the positive effects from obesity surgery in adults also can be achieved when adolescent subjects are operated. Our hypothesis is that the effects concerning weight loss, health improvement and improved quality of life will be as good in adolescents as in adults.

NCT ID: NCT00238836 Active, not recruiting - Hypertension Clinical Trials

Anticipatory & Preventive Team Care (APTCare): At Risk Patients of Family Health Networks

Start date: n/a
Phase: Phase 2/Phase 3
Study type: Interventional

The University of Ottawa and Élisabeth Bruyère Research Institute are conducting a study of preventive care for frail patients at risk of functional decline. At risk patients are assigned by chance to continue receiving their standard care from their family physician or receive additional care from a nurse practitioners and a pharmacist. In collaboration with the family physician, they develop an individualized care plan, a treatment and management road plan, for each patient, which they implement over the study period of one approximately year. The objective of the study is to compare the effectiveness of the model of care that includes the nurse practitioners and pharmacist against standard care in preventing functional decline, to determine the acceptability of this model of care to patients, their caregivers and the medical team, and to evaluate the cost implication of the program.

NCT ID: NCT00210275 Active, not recruiting - Hypertension Clinical Trials

Ontario Printed Educational Materials (PEMs) for Physician Behaviour Change

OPEMS
Start date: July 2005
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether printed educational materials can change physician behaviour towards more evidence based decision-making.

NCT ID: NCT00198562 Active, not recruiting - Hypertension Clinical Trials

Hypertension Control Based on Home Blood Pressure

Start date: April 2000
Phase: Phase 4
Study type: Interventional

The aim of this trial is to study the effects of antihypertensive therapy based on home systolic blood pressure (BP) with different target levels using two classes of drugs. The HOSP study is a multicenter, prospective, randomized, open, blinded endpoint study. The study subjects are 40-79 years old hypertensive patients. After a 4 weeks of baseline period, subjects are randomly assigned to (1) modest control group (morning home BP <140 mmHg) or (2) strict control group (morning home BP <130 mmHg), and to (a) amlodipine group or (b) losartan group. Additional antihypertensive drugs can be used if home BP is not controlled. Home BP is measured in the early morning and late evening. The participants will be followed up for 5 years.

NCT ID: NCT00195182 Active, not recruiting - Hypertension Clinical Trials

Psychosocial Determinants of Medication Adherence in Hypertensive African Americans

Start date: September 2003
Phase: N/A
Study type: Observational

The specific aims for this study are: 1. To examine the relationship between perceived racism and medication adherence among hypertensive African-American patients. 2. To determine if psychological stress and depression mediate the relationship between perceived racism and medication adherence.

NCT ID: NCT00150631 Active, not recruiting - Hypertension Clinical Trials

Danish Hypertension Prevention Project - DHYPP

Start date: November 2000
Phase: Phase 3
Study type: Interventional

The present study examine healthy, normotensive subjects 18 to 36 years of age whose both parents have essential hypertension. The subjects receive treatment with either the AT1-antagonist candesartan cilexetil, 16 mg daily or placebo for one year. Then, treatment is withdrawn and the subjects is followed for 10 years to determine if the treatment has been able to either prevent or delay the development of hypertension. The primary objective is to determine whether pharmacological treatment with an angiotensin receptor blocker is able to restrain or delay the progression to hypertension. Secondary objectives are to investigate whether any long-term effect on blood pressure is related to the effect of treatment on renal haemodynamic function, or on the left ventricle mass.

NCT ID: NCT00144937 Active, not recruiting - Hypertension Clinical Trials

Multifactorial Intervention on Cardiovascular Risk Factors in Subjects With Peripheral Arterial Disease

Start date: March 2003
Phase: Phase 4
Study type: Interventional

The purpose of this study was to evaluate whether an intensified multifactorial intervention program about cardiovascular risk factors in subjects with peripheral arterial disease (with and without diabetes mellitus), can improve the control of these factors (mainly hypercholesterolemia and hypertension) in relation to the habitual care

NCT ID: NCT00144144 Active, not recruiting - Hypertension Clinical Trials

A Study on Ca Blocker Versus AII Antagonists in Hypertension With Type 2 Diabetes

Start date: September 2004
Phase: Phase 4
Study type: Interventional

The antihypertensive effect of the increased dose of angiotensin II receptor blocker (AII antagonist) is compared with that of the additional combined use of amlodipine in hypertensive patients with Type 2 diabetes mellitus, who have been treated with AII antagonist, the antihypertensive effect of which has been inadequate.

NCT ID: NCT00133328 Active, not recruiting - Hypertension Clinical Trials

A Morbidity-Mortality and Remodeling Study With Valsartan

Start date: January 2002
Phase: Phase 4
Study type: Interventional

The JIKEI HEART Study has been designed to investigate whether concomitant treatment with valsartan, an angiotensin II receptor blocker (ARB), in addition to conventional treatment, will improve the prognosis of 3000 Japanese patients with cardiovascular diseases.