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Evaluating Drug Interactions Between Doravirine With Estradiol and Spironolactone in Healthy Transgender Women — IDENTIFY  

Human Immunodeficiency Virus Clinical Trial

Official title:
A Prospective, Randomized, Three-period Crossover, Interaction Study to Evaluate the Pharmacokinetics of Doravirine and Tenofovir Disoproxil Fumarate Co-administered With Cross-sex Hormonal Therapy in Adult HIV-negative Transgender Women

Clinical Trial Summary

Transgender women living with Human Immunodeficiency Virus (HIV) may prioritize gender-affirming hormonal therapy over antiretroviral drug therapy. Hormonal therapy typically consists of oral estradiol and spironolactone, which induce drug-metabolizing enzymes after prolonged administration. This study evaluates the bi-directional potential drug interaction between the antiretroviral drug, doravirine, when co-administered with estradiol and spironolactone.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04283656
Study type Interventional
Source Thomas Jefferson University
Contact
Status Completed
Phase Phase 1
Start date February 14, 2022
Completion date December 30, 2022
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