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Negative Serology by Immunoenzymatic Test (EIA) in HIV-infected Children Treated Early With Antiretroviral in the ANRS-Pediacam Study: Pathophysiological Mechanisms — PediacamNEG  

HIV Infections Clinical Trial

Official title:
Negative Serology by Immunoenzymatic Test (EIA) in HIV-infected Children Treated Early With Antiretroviral in the ANRS-Pediacam Study: Pathophysiological Mechanisms

Clinical Trial Summary

The objective of the study is to identify the pathophysiological mechanisms responsible for the induction and maintenance of negative serologies by EIA tests in HIV-infected children treated early with HAART in the ANRS 12225-Pediacam III cohort in Cameroon The hypothesis of better control of HIV infection through interactions between immunological, viral, and genetic factors was made to build the following objectives: - Immunological aspect: lack of humoral response or immune activation - Virological aspect: Reduced HIV reservoir size - Determine the HLA phenotype in the different groups of children included and the KIR genotypes.

Clinical Trial Description

There will be two phases of the study : - A retrospective phase: case-control study The analyzed data are those collected previously or measured from the already available bio bank, within the framework of the Pediacam III cohort during the primary infection phase before the initiation of HAART, at 6 months after the end of the first series of EPI vaccines, and at 2 years. - A prospective phase: cross-sectional study Based on an ad hoc bio bank created for parameters we couldn't measure on the existing bio bank ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06302933
Study type Interventional
Source ANRS, Emerging Infectious Diseases
Contact Mathurin C Tejiokem, Doctor
Phone +237222231803
Email tejiokem@pasteur-yaounde.org
Status Recruiting
Phase N/A
Start date May 2, 2024
Completion date August 30, 2025
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