Assessing the Use of MY-RIDE, a Just-in-time Adaptive Intervention, to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness

HIV Infections Clinical Trial

Official title:

Assessing the Use of MY-RIDE, a Just-in-time Adaptive Intervention, to Improve HIV Prevention and Substance Use in Youth Experiencing Homelessness

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06074354
• Other study ID #: HSC-SN-23-0360
• Status: Not yet recruiting
• Phase: N/A
• Start date: August 1, 2024
• Est. completion date: June 1, 2026

Study information

• Verified date: May 2024
• Source: The University of Texas Health Science Center, Houston
• Contact: Diane M Santa Maria, DrPH, MSN, RN, PHNA-BC, FSAHM,
• Phone: 713-500-2002
• Email: Diane.M.SantaMaria[@]uth.tmc.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether Motivating Youth to Reduce Infections, Disconnections, and Emotion dysregulation (MY-RIDE) decreases substance use , to determine whether MY-RIDE increases human immunodeficiency virus (HIV) prevention strategies and to evaluate MY-RIDE effects on willingness to take Pre-Exposure Prophylaxis (PrEP), stress, substance use urge, and use of mental health and substance use services when compared to attention control youth

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 450
• Est. completion date: June 1, 2026
• Est. primary completion date: June 1, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 25 Years

Eligibility

Inclusion Criteria:

• have engaged in substance use (alcohol or illicit drugs)
• speak English
• are experiencing homelessness
• engaged in sexual activity in the last 6 months or plan to in the next month
• are not planning to move out of the metro area during the 12-month study period.

Exclusion Criteria:

• Youth Experiencing Homelessness (YEH) who have low literacy based on the Rapid Estimate of Adult Literacy in Medicine-Short Form (scores < 4)

Related Conditions & MeSH terms

• HIV Infections
• Substance-Related Disorders

Intervention

Behavioral:
• Attention-control group
Participants will receive a one-hour general health promotion session from a nurse and be issued a phone that will deploy the EMA on the same schedule as the intervention arm. They will also receive usual care from the clinics, drop-in center, and shelter recruitment sites. Usual care includes accessing social workers and case managers for immediate housing, food, and clothing needs and assistance in navigating the local Continuum of Care system to access social services.
• MY-RIDE group
MY-RIDE has three main components: 1) One nurse-led face-to-face session; 2) three months of Ecological Momentary Assessments (EMA) with personalized messaging delivered by phone in real-time in response to one's current risk; and 3) access to on-demand healthcare/PrEP navigation and referrals.

Locations

Country	Name	City	State
United States	The University of Texas Health Science Center at Houston	Houston	Texas

Sponsors (2)

Lead Sponsor	Collaborator
The University of Texas Health Science Center, Houston	National Institute of Nursing Research (NINR)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in substance use		baseline, 3, 6, and 12 months
Secondary	Change in condom use		baseline, 3, 6, and 12 months
Secondary	Change in PrEP uptake as assessed by the self reported tool	PrEP uptake is defined as the self initiation of HIV prevention medication	baseline, 3, 6, and 12 months
Secondary	Change in sexually transmitted infections (STIs)	This will be assessed by a blood test to detect biomarkers for HIV and Syphilis, and urine test for Gonorrhea and Chlamydia	baseline, 3, 6, and 12 months