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Gut and Vaginal Microbiota Profile Study for HIV Women

HIV Infections Clinical Trial

Official title:
A Cohort Study Among HIV Infected Women：Exploring the Regulatory Mechanism of Gut and Vaginal Microbiota in HPV Infection and Cervical Lesion

Clinical Trial Summary

Women Living with HIV Infection （WLHIV）are intended to acquire HPV infection which usually contributes to variable cervical lesions. we hypothesize that vaginal microbiota imbalance may make WLHIV prone to HPV infection，thereafter results in severe cervical lesion.

Clinical Trial Description

Women Living with HIV Infection （WLHIV）are intended to acquire HPV infection which usually contributes to variable cervical lesions. Besides the HPV co-infection, microbiota study recently reveals that the changes of vaginal bacteria spectrum might also be related with cervical disease in WLHIV. However, data on HPV prevalence in WLHIV and its associated cervical lesion incidence is still limited in China. Moreover, the causal relationship between vaginal microbiota and cervical lesion in WLHIV is not clear. Here, we hypothesize that vaginal microbiota imbalance may make WLHIV prone to HPV infection，thereafter results in severe cervical lesion. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05996016
Study type Observational [Patient Registry]
Source Peking Union Medical College Hospital
Contact Wei Lyu, MD
Phone 13501385800
Email lvweipumch@163.com
Status Recruiting
Phase
Start date November 9, 2022
Completion date July 31, 2026
View Details
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