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Aging With HIV and Neurocognitive Decline, a Follow-up Study — AgingHAND  

HIV Infections Clinical Trial

Official title:
Aging With HIV and Neurocognitive Decline, a Follow-up Study

Clinical Trial Summary

The ANRS ( Agence Nationale de Recherches sur le Sida et les Hépatites virales) 0093s Aging HAND study is to assess whether PLHIV (People Living with HIV) initially between 55-70 years of age at baseline analysis under antiretroviral therapy have accelerated decline of neurocognitive function after 6 years of follow-up. Aging HAND is a French, multicentric, longitudinal, transversal, prospective study with inclusion of 290 PLHIV.

Clinical Trial Description

The primary objective of this study is to analyze whether PLHIV initially aged between 55-70 years of age at baseline under antiretroviral therapy have accelerated decline of neurocognitive function after 6 years of follow-up in comparison with an age, gender and educational level matched HIV non-exposed control group from the CONSTANCES cohort. The secondary objectives of this study are : - To determine the prevalence of neurocognitive impairment (NCI) according to the Frascati criteria, clinical consensus and alternative classifications, after additional accrual of individuals aged 55 to 76 years for a more precise and extensive age range analysis of NCI - To describe the incidence and prevalence of the frailty syndromes, and their relation with co-morbidities and NCI, using the Fried score as a measure of frailty - To constitute a plasma and serum biobank for biomarkers study related to the aging of PLHIV ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05385588
Study type Interventional
Source ANRS, Emerging Infectious Diseases
Contact Valérie Andriantsoanirina
Phone +33 (0) 1 49 59 19 83
Email valerie.andriantsoanirina@inserm.fr
Status Recruiting
Phase N/A
Start date November 14, 2022
Completion date February 2025
View Details
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