HIV Infections Clinical Trial
Official title:
Venue-Based Recruitment and HIV Prevention for Alcohol and Other Drug (AOD) Using Couples in South Africa
Couples who use alcohol and other drugs (AOD) in South Africa are at high risk for engaging
in risky sex behavior within their relationships and with other sexual partners. In
addition, high levels of gender-based violence (GBV) in the Cape Town area intersect with
AOD abuse and sex behavior. All of these interconnections raise concern for the importance
of HIV prevention strategies within or surrounding drinking venues, where many of these
behaviors occur.
The specific aims of this study are as follows:
Aim 1. To characterize the types of drinking venues (e.g., licensure status, size, plumbing,
type of alcohol provided), their immediate context (e.g., observed availability and use of
other drugs, observable violence and sexual activity), and surrounding neighborhood
characteristics (e.g., quality of streets, building structures, and availability of
electricity and plumbing) in the sampled neighborhood blocks in several large Black/African
and Coloured communities in Cape Town, South Africa.
Aim 2. To refine through qualitative methods the proposed interventions in relation to
skills-building to address gender-role expectations, sexual partnering, gender and power,
violence, and environments where drinking and sexual risk behaviors occur.
Aim 3. To conduct a randomized group trial to compare the relative efficacy of a
comprehensive intervention (Condition 3: Enhanced Couples) to the gender-focused
intervention (Condition 2: Gender) and to (Condition 1: Men's Control and Women's CoOp) on
reducing alcohol and other drug (AOD) use, sexual risk behavior, and gender-based violence
at 6 month follow-ups. Aim 4. To assess the mechanisms through which the intervention
effects may occur (e.g., mediators involving self-efficacy and condom mastery, negotiation,
and communication skills) and to identify groups for whom the interventions have the
greatest effect (e.g., partner characteristics such as race, gender, and age and
neighborhood factors such as poverty) on study outcomes of AOD use, sexual risk, and
gender-based violence.
n/a
Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
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