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NCT00806845 Clinical Trial

Examination of B Cell Responses in Human Blood

HIV Infections Clinical Trial

Official title:
Gewinnung Humaner antikörperproduzierender Zellen Aus Dem Blut

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00806845
Other study ID # RegMedNet-001
Secondary ID
Status Completed
Phase N/A
First received December 10, 2008
Last updated May 12, 2015
Start date July 2008
Est. completion date February 2010

Study information
Verified date May 2015
Source Regenerative Medicine Network
Contact n/a
Is FDA regulated No
Health authority Germany: Ethics Commission
Study type Observational

Clinical Trial Summary

The aim of this study is the assessment B-cell immune responses in HIV-infected individuals.

Description:

Groups of patients with different immune competencies will be examined. The impact of HIV infection on immune response will be assessed.

Recruitment information / eligibility
Status Completed
Enrollment 50
Est. completion date February 2010
Est. primary completion date December 2009
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- HIV-infected individuals

- controls

Exclusion Criteria:

- none

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Germany Universität Leipzig Leipzig Sachsen

Sponsors (2)
Lead Sponsor Collaborator
Regenerative Medicine Network University of Leipzig

Country where clinical trial is conducted

Germany, 

References & Publications (3)

Bussmann BM, Reiche S, Bieniek B, Krznaric I, Ackermann F, Jassoy C. Loss of HIV-specific memory B-cells as a potential mechanism for the dysfunction of the humoral immune response against HIV. Virology. 2010 Feb 5;397(1):7-13. doi: 10.1016/j.virol.2009.1 — View Citation

Kunz K, Reiche S, Dwai Y, Cordes C, Krznaric I, Bussmann BM, Jassoy C. A broad spectrum of functional HIV-specific memory B cells in the blood of infected individuals with high CD4+ T-cell counts. J Acquir Immune Defic Syndr. 2011 Jul 1;57(3):e56-8. doi: — View Citation

Reiche S, Nestler C, Sieg M, Schulz K, Cordes C, Krznaric I, Jassoy C. Hepatitis C virus (HCV)-specific memory B-cell responses in transiently and chronically infected HIV positive individuals. J Clin Virol. 2014 Apr;59(4):218-22. doi: 10.1016/j.jcv.2014. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Antigen specific B-cell responses 18 months No
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