HIV Infections Clinical Trial
Official title:
Efficacy and Security of Annual and Biennial Zoledronic Acid for Osteoporosis Treatment in an HIV-infected Patients' Cohort
The purpose of this project is to determine the incidence of osteoporosis in the investigators' population of HIV-infected patients and to assess the efficacy and security of zoledronic acid, whose efficacy in post-menopausal women with high fracture risk treatment and in Paget's disease treatment has already been demonstrated.
The lower bone mineral density that has been described in patients with HIV-infection has not
meant an increase of long term complications. Nevertheless, it could involve an increase if
the associated co-morbidity in the future, taking in care that in general population
osteoporosis increases 4 times the pathologic fracture risk. That is why it is necessary to
know the real prevalence of osteoporosis in this population of patients so the real
dimensions of the problems can be defined.
This project wills to determine the incidence of osteoporosis in our population of
HIV-infected patients and to assess the efficacy and security of zoledronic acid. If the
annual use of endovenous zoledronic acid obtains equivalent results to those obtained with
oral and weekly alendronate in other studies with the same population, its use would be
justified because of its posology benefits. The annual administration can improve compliance
in patients who are receiving a big quantity of drugs, as HIV-infected patients do, and who
probably have to be treated for life. Moreover, its elimination is renal so there is absence
of interactions with antiretroviral drugs what makes of zoledronic acid a very promising
alternative. Finally, there is no risk of digestive intolerance because of its parenteral
administration and it has a better posology than oral bisphosphonates.
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