Genetic Predictors of Raltegravir Penetration Into Cerebrospinal Fluid

Status Completed

Clinical Trial Summary

This study is being done to find out how much of the drug raltegravir (RGV) gets into cerebrospinal fluid (CSF), compared to how much get into the blood and to find out if normal changes in a certain gene in your body affects how much RGV gets into the CSF.

Clinical Trial Description

The multidrug efflux transporter P-glycoprotein (P-gp) is expressed in the blood-brain barrier where it limits entry of substrate drugs into the central nervous system. Raltegravir (MK-0158), a new HIV-1 integrase inhibitor and potentially major addition to the therapeutic armamentarium against HIV, is a substrate for P-gp. Studies are warranted to elucidate the relevance of P-gp transport for raltegravir in the central nervous system. ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

HIV Infections

Clinical Trial Details

NCT number	NCT00729924
Study type	Interventional
Source	Vanderbilt University
Contact
Status	Completed
Phase	Phase 2/Phase 3
Start date	August 2008
Completion date	August 2011

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