HIV Infections Clinical Trial
Official title:
Biobehavioral Effects of Mindfulness-Based Stress Reduction in HIV
The purpose of this study is to investigate whether Mindfulness-Based Stress Reduction (MBSR) vs a one-day MBSR seminar improves immune (CD4+ T lymphocytes) and virological (HIV viral load) status in HIV-1 infected adults. The secondary goal of the study is to determine if MBSR vs a one-day MBSR seminar improves self-reported HIV-related quality of life.
Mindfulness meditation, which is described as a process of bringing awareness to
moment-to-moment experience, has been receiving substantial scientific attention as a
process that can be stress and health protective (Brown, Ryan, & Creswell, 2007). Recent
reviews by Baer (2003), Bishop (2002), and Grossman et al (2004) support the effectiveness
of the standardized and manualized MBSR program in reducing stress and functional disability
in a variety of chronic illnesses, although no studies have tested if MBSR impacts clinical
markers of HIV, although some evidence suggests that MBSR improves some markers of innate
immunity and quality of life in HIV-infected adults (see Robinson, Mathews, & Witek-Janusek,
2003). In this study, we propose to extend this work by investigating the impact of this
intervention on biological and functional health status in HIV-positive adults.
We propose to determine whether the 8-week MBSR program is more effective than a one-day
MBSR seminar in: (1) maintaining immune resistance in HIV infection (i.e. maintaining counts
of CD4+ T lymphocytes and reducing HIV viral load), and (2) improving HIV-related quality of
life. Additional analyses will test for a dose-response effect of MBSR by examining if MBSR
class attendance and daily meditation practice are associated with the primary and secondary
outcomes. These aims will be tested in a sample of 50 HIV-positive adults that is diverse
with respect to ethnicity, gender and sexual orientation.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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