Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS

HIV Infections Clinical Trial

Official title:

Phase 1 Correlation Between Intestinal Parasites and Serum Level of Eosinophils and IgE in Individuals With HIV or AIDS

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00546689
• Other study ID #: upeclin/HC/FMB-Unesp-02
• Secondary ID: Botucatu Medical
• Status: Completed
• Phase: N/A
• First received: October 18, 2007
• Last updated: April 17, 2008
• Start date: March 2007
• Est. completion date: August 2007

Study information

• Verified date: October 2007
• Source: UPECLIN HC FM Botucatu Unesp
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in ResearchBrazil: National Health Surveillance AgencyBrazil: Ministry of Health
• Study type: Observational

Clinical Trial Summary

Correlation between intestinal parasites and serum level of eosinophils and IgE in individuals with HIV or aids attended at clinical hospital of the Botucatu Medical School-UNESP

Description:

The present study correlates intestinal parasitism and levels of eosonophils and of serum IgEs in patients attended at the C.H. of the School of Medicine - Botucatu/UNESP. Thirty adult patients with AIDS were analyzed in the use of HAART, aged 42 ±11 years, 14 (46.7%) male, excluding those that had used anthelminthics 30 days prior to collection. Socioeconomic questionaires were applied and 3 samples of feces were taken for parasitological exams (TF-test® method) and 5 ml of blood for counting eosinophils (automated hematological counter, Pentra 80, ABX) and IgE doses (equipment BN-100, Dade-Behring). The index of parasites was 10%, with E.nana (3.3%), E.coli (3.3%) and B.hominis (3.3%). Parasitized individuals were from an urban region with complete basic sanitation and good socioeconomic level. Normal eosinphil values were found in all samples and increased IgE values in 1 (33.3%) sample. The index of parasites was low due to good socioeconomic level and disease control. Augmented IgE levels corroborate the literature, which reports an increase characteristic of immune response in the face of parasitic infections in individuals with HIV or AIDS. In conclusion, new studies should be undertaken to evaluate the level of eosinophils associated with cytokines to obtain a better understanding of this correlation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: August 2007
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• HIV or AIDS

• age same or superior to 18 years,

• both sexes

• assisted by the Hospital of the Clinics of Botucatu Medical School-UNESP

Exclusion Criteria:

• use of anthelminthic in the period of 30 days antecedents the it dates from collection

• individuals that don't have all of the necessary evaluations to the objectives of the study

• individuals that abandon the attendance, or that you/they are to death during the study

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• HIV Infections
• Intestinal Diseases, Parasitic

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
UPECLIN HC FM Botucatu Unesp

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	all		one year
Secondary	all		one year