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Further Evaluation of Thalidomide's Ability to Potentiate the Immune Response to HIV-Infected Patients

HIV Infections Clinical Trial

Official title:
Further Evaluation of Thalidomide's Ability to Potentiate the Immune Response to HIV-Infected Patients

Clinical Trial Summary

To determine if Thalidomide modulates the production of HIV-suppressor factors (MIP-1 alpha, MIP-1 beta, Rantes) and TH1 type cytokines (IL-12 and INF-gamma) in HIV-infected patients and alters viral load.

Clinical Trial Description

Patients will be divided, 5 per group, into Groups I, II, III and IV. Groups I and II will include patients who have decided not to take anti-retro viral drugs. Groups III and IV will include patients receiving the same types of antiretroviral drugs. Patients in groups I and III will receive thalidomide while patients in group II and IV will receive placebo. The placebo capsules will be the same color as the thalidomide capsules and will contain glucose powder. Patients will ingest one capsule of thalidomide at 9 PM daily on days 0, 1, 2, 3, 4, 5 and 6. ;

Study Design

Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00002174
Study type Interventional
Source NIH AIDS Clinical Trials Information Service
Contact
Status Completed
Phase N/A
View Details
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