HIV Infections Clinical Trial
Official title:
Acupuncture and Herbal Treatment of Chronic HIV Sinusitis
To compare Traditional Chinese Medicine versus standard antibiotic therapy consisting of
pseudoephedrine ( Sudafed ) plus amoxicillin / clavulanate potassium combination ( Augmentin
) in reducing symptoms and recurrence of acute HIV-related sinusitis.
Chronic sinusitis in HIV-infected individuals is a recurrent and persistent infection with
potentially serious complications: it can exacerbate pulmonary disease, cause recurrences of
life-threatening sepsis, and progress to central nervous system involvement. Symptoms of
sinusitis in HIV patients are often refractory to aggressive Western medical management, and
antibiotic intolerance can occur. Traditional Chinese Medicine consisting of acupuncture and
herbal treatment may provide a low-risk, low-cost alternative to conventional antibiotic
therapy.
Chronic sinusitis in HIV-infected individuals is a recurrent and persistent infection with
potentially serious complications: it can exacerbate pulmonary disease, cause recurrences of
life-threatening sepsis, and progress to central nervous system involvement. Symptoms of
sinusitis in HIV patients are often refractory to aggressive Western medical management, and
antibiotic intolerance can occur. Traditional Chinese Medicine consisting of acupuncture and
herbal treatment may provide a low-risk, low-cost alternative to conventional antibiotic
therapy.
Patients are randomized to receive either Traditional Chinese Medicine (acupuncture and
herbal treatment) or conventional antibiotic therapy (Sudafed and Augmentin). Treatment
continues for 8 weeks, followed by a 4 week washout, with final follow-up at week 12.
Patients must undergo endoscopic nasal exam and CT scan of paranasal sinus prior to study
entry and at week 12.
;
Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Primary Purpose: Treatment
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